Cholangioblastic Cholangiocarcinoma (NIPBL::NACC1 cholangiocarcinoma): Expanded Morphologic Spectrum and Further Genetic Characterization [0.03%]
胆管树突发癌（NIPBL::NACC1 胆管癌）：扩展的形态学谱系及进一步的遗传表征
Pedram Argani,Kiyoko Oshima,Robert A Anders et al.
Pedram Argani et al.
The cholangioblastic variant of intrahepatic cholangiocarcinoma is a distinctive neoplasm that typically affects young women without underlying liver disease. Morphologically, it demonstrates solid, trabecular, and tubulocystic architecture...
Ovarian Carcinomas: Clinicopathologic and Molecular Features With Comments on 2014 FIGO Staging [0.03%]
卵巢癌的临床病理及分子特点与2014年FIGO分期评论
Jaime Prat,Emanuela D&#x;Angelo,Iñigo Espinosa
Jaime Prat
According to histopathology and molecular genetics, there are 5 major subtypes of ovarian carcinomas: high-grade serous (70%), endometrioid (10%), clear cell (10%), mucinous (3% to 4%), and low-grade serous (
Sialoblastomas With Solid Pattern Have FGFR2 Mutations and an Unfavorable Prognosis [0.03%]
实发性唾液腺肿瘤具有固态模式、FGFR2基因突变及不良预后
Xiaoli Jia,NanNan Leng,Min Wang et al.
Xiaoli Jia et al.
Although sialoblastoma (SBL) is defined as a low-grade malignant salivary gland anlage neoplasm in the 2022 World Health Organization (WHO) Classification of Head and Neck Tumors, its histology, genetics, and behavior remain controversial d...
Aberrant E-cadherin Expression in Lobular Carcinoma In Situ: A Comprehensive Immunohistochemical Evaluation of N-terminal, Extracellular, and C-terminal E-cadherin Domains [0.03%]
乳头状癌原位的E-钙粘蛋白表达异常：N端、细胞外和C端E-钙粘蛋白区域免疫组化分析综合评价
Rita Canas-Marques,Ana Blanca,Raquel Graça-Lopes et al.
Rita Canas-Marques et al.
E-cadherin (E-cad) immunohistochemistry is commonly used to distinguish lobular carcinoma in situ (LCIS) from ductal carcinoma in situ in histologically uncertain or ambiguous cases. Although most LCIS cases show an absence of E-cad express...
Quantifying Tumor Budding: Implications for Prognosis in Gastric Adenocarcinoma [0.03%]
胃腺癌中肿瘤芽状生长的量化及其预后的意义
Jie Lian,Wenwen Zhang,Chunbao Wang et al.
Jie Lian et al.
The mechanism of tumor budding (TB) in gastric adenocarcinoma (GAC) and its relationship with biological indicators and prognostic significance, remains unclear. In this study, we conducted a comprehensive analysis using whole-slide imaging...
Clinicopathologic and Molecular Characterization of Basal Cell Carcinoma Arising at Sun-protected Sites [0.03%]
防护紫外线部位基底细胞癌的临床病理和分子特征分析
Elizabeth Draper,Yvonne Y Li,Navin R Mahadevan et al.
Elizabeth Draper et al.
Basal cell carcinomas (BCC) are driven primarily by cumulative ultraviolet (UV) radiation exposure resulting in activation of the Hedgehog (Hh) signaling pathway, often as a result of UV-mediated Patched-1 (PTCH1) gene inactivation. Accordi...
Increased SOX10, p16, and Cyclin D1 Immunoreactivity Differentiates MAP Kinase-activated Low-grade Gliomas From Piloid Gliosis [0.03%]
SOX10、p16和Cyclin D1的免疫反应性增加可将MAP激酶激活的低级别胶质瘤与 piloid 胶质炎区分开来
Vivian Tang,Kevin Y Zhang,Kanish Mirchia et al.
Vivian Tang et al.
Low-grade gliomas and reactive piloid gliosis can present with overlapping features on conventional histology. Given the large implications for patient treatment, there is a need for effective methods to discriminate these morphologically s...
Clinical, Pathologic, and Molecular spectrum of Angioinmmunoblastic T-cell Lymphoma Cutaneous Lesions: Clinical, Pathologic, and Molecular Analysis [0.03%]
血管免疫母T细胞淋巴瘤皮损的临床、病理和分子特征分析
Francisco Javier Díaz de la Pinta,M Ángeles Pérez-Guillermo Cuevas,Rebeca Manso et al.
Francisco Javier Díaz de la Pinta et al.
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive malignancy that frequently presents with extranodal involvement. Cutaneous tropism is clinically and histopathologically variable, which may pose a diagnostic challenge. We conducte...
Ipsilateral Breast Carcinoma Recurrence: True Recurrence or New Primary? A Clinicopathologic and Molecular Study [0.03%]
同侧乳腺癌复发：真正的复发还是新的原发肿瘤？临床病理和分子研究
María Fernández-Abad,Tamara Caniego-Casas,Irene Carretero-Barrio et al.
María Fernández-Abad et al.
Determining whether an ipsilateral breast carcinoma recurrence is a true recurrence or a new primary remains challenging based solely on clinicopathologic features. Algorithms based on these features have estimated that up to 68% of recurre...
A Proposal for Revised and Simplified Renal Pelvic Urothelial Carcinoma Staging Criteria: A Clinicopathologic Study of 141 Tumors [0.03%]
肾盂尿路上皮癌分期标准修订及简化方案的临床病理研究（141例）
Miranda E Machacek,Hanzhang Wang,Kyle Devins et al.
Miranda E Machacek et al.
Staging of renal pelvic urothelial carcinoma can be challenging due to anatomic variation at the renal pelvis compared with ureter and bladder and calls into question the prognostic accuracy of the current TNM staging. In this study, we det...