Malignant Giant Cell Tumor of Bone: A Clinicopathologic Series of 28 Cases Highlighting Genetic Differences Compared With Conventional, Atypical, and Metastasizing Conventional Tumors [0.03%]
骨恶性巨细胞瘤：包含28例病例的临床病理系列，强调与常规、非典型以及转移性常规肿瘤相比的遗传差异
David J Papke Jr,S Krisztian Kovacs,Igor Odintsov et al.
David J Papke Jr et al.
Giant cell tumors of bone are locally aggressive, frequently harbor H3F3A p.G34W mutations, and rarely undergo malignant transformation. The pathogenesis of malignant transformation remains incompletely characterized. Herein, we present 28 ...
Odontogenic Myxoma Harbors Widespread Loss of Heterozygosity and Not Trisomies [0.03%]
牙源性黏液瘤中存在广泛的杂合性缺失但没有三体性
Igor Odintsov,Tony G Kleijn,Scott T Ryall et al.
Igor Odintsov et al.
A Clinical, Morphologic, and Molecular Comparison of Bonafide Spitz Melanomas and ASTs in the Pediatric Population [0.03%]
儿童良性和恶性棘黑素细胞瘤的临床，形态和分子比较研究
Haya Mary Beydoun,Julia Edwin Jeyakumar,Afua Addo et al.
Haya Mary Beydoun et al.
Pediatric Spitz melanoma (SM) with bonafide metastatic disease is rare. In this study, we assembled the largest cohort to date of pediatric SM with a verified Spitz-associated genomic driver and clinical follow-up demonstrating bonafide met...
Somatic Malignancies Arising in Ovarian Mature Cystic Teratomas: A Multi-Institutional Study of 40 Cases Highlighting Outcomes and Novel Malignancies [0.03%]
卵巢成熟囊性畸胎瘤中出现的体细胞恶性肿瘤：40例病例的多机构研究，强调结果和新型恶性肿瘤
Grace Neville,Kyle M Devins,Marisa R Nucci et al.
Grace Neville et al.
Somatic malignancy arising in ovarian mature cystic teratoma (MCT) is a relatively rare phenomenon with an estimated incidence ranging from 0.17% to 5.5%. Most previous studies have been limited by small sample sizes, hindering more precise...
Cutaneous Hemangioma With Epithelioid Features Harboring TPM3/4::ALK Fusions: A Distinct Entity or a Molecular Variant of Epithelioid Hemangioma? [0.03%]
具有上皮样特征并含有TPM3/4::ALK融合的皮肤血管瘤：一个独立的实体还是上皮样血管瘤的一种分子变异？
Carina A Dehner,George Jour,Maximilian Gassenmaier et al.
Carina A Dehner et al.
Vascular neoplasms with epithelioid cytomorphology encompass a wide spectrum of benign and malignant lesions, including epithelioid hemangioma (EH), cutaneous epithelioid angiomatous nodule (CEAN), epithelioid hemangioendothelioma (EHE), an...
Primary Endometrial Gastric (Gastrointestinal)-type Mucinous Adenocarcinoma: A Detailed Clinicopathologic and Molecular Analysis of 27 Cases [0.03%]
原发性子宫胃型(胃肠型)粘液腺癌：27例详细的临床病理和分子分析
Harsimar Kaur,Lawrence Hsu Lin,David L Kolin et al.
Harsimar Kaur et al.
Endometrial gastric (gastrointestinal)-type mucinous adenocarcinoma (EmGA) is rare and was introduced as a new entity in the latest World Health Organization (WHO) classification of female genital tumors. Herein, we report a detailed clinic...
CK17 Immunohistochemistry Is a Useful Adjunct in the Diagnosis of HPV-independent, TP53-wild-type Verruciform/Acanthotic Vulvar Intraepithelial Neoplasia (vaVIN) [0.03%]
CK17免疫组织化学对HPV独立型，TP53野生型的菜花状/棘皮瘤样外阴上皮内瘤变(vaVIN)诊断的辅助作用
Emily M Hartsough,Rosalynn M Nazarian,Jaclyn C Watkins
Emily M Hartsough
Verruciform/acanthotic vulvar intraepithelial neoplasia (vaVIN) is a rare, recently defined HPV-independent, TP53-wild type lesion of the vulva that predisposes to vulvar squamous cell carcinoma (VSCC). VaVIN encompasses a variety of histom...
Expanding the Molecular-genetic Spectrum of Canalicular Adenoma-like Subtype of Pleomorphic Adenoma of Salivary Glands [0.03%]
唾液腺多形性腺瘤导管状腺瘤样亚型的分子遗传谱系扩展研究
Natálie Klubíčková,Frederica Loghides,Mari F C M van den Hout et al.
Natálie Klubíčková et al.
Canalicular tumors of the salivary glands have recently emerged as an entity characterized by distinct morphology and recurrent HMGA2 gene rearrangement. In this study, we analyzed 40 cases intending to elucidate their features further. The...
High-accuracy Detection of PD-L1 3'-UTR Disruption by Immunohistochemistry and Fluorescence in Situ Hybridization on Formalin-fixed Paraffin-embedded Sections [0.03%]
通过福尔马林固定石蜡包埋组织切片的免疫组化和荧光原位杂交高精度检测PD-L1 3'-UTR的断裂
Ayumi Fujimoto,Seiji Sakata,Keisuke Kataoka et al.
Ayumi Fujimoto et al.
Programmed death-ligand 1 (PD-L1/CD274) structural variation (SV) disrupting the 3'-untranslated region has been highlighted as being associated with PD-L1 overexpression. In the present study, we evaluated lymphoma tissue samples to invest...
Atypical Intraductal Proliferation in Prostate Needle Core Biopsy: Validation as a Marker of Unsampled Adverse Pathology in a Clinicopathologic Series of 142 New Patients [0.03%]
前列腺针活检中的非典型导管内增生：在142例新病人的临床病理系列中验证其作为未采样的不良病理标记物的价值
Roshan Bhattarai,Jesse K McKenney,Reza Alaghehbandan et al.
Roshan Bhattarai et al.
Atypical intraductal proliferation (AIP) of the prostate is characterized by morphologic features exceeding that of high-grade prostatic intraepithelial neoplasia but not meeting strict diagnostic criteria for intraductal carcinoma. We exam...