CNS Low-grade Diffusely Infiltrative Tumors With INI1 Deficiency, Possessing a High Propensity to Progress to Secondary INI1-deficient Rhabdoid Tumors [0.03%]
具有向继发性INI1缺陷的横纹肌肉瘤进展高倾向性的中枢神经系统低级别弥漫浸润性INI1缺陷肿瘤
Sumihito Nobusawa,Satoshi Nakata,Yoshiko Nakano et al.
Sumihito Nobusawa et al.
Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant tumors of the central nervous system that predominantly occur in infants, and are characterized by the presence of rhabdoid cells and inactivation of INI1 or (rarely) BRG1. Mos...
Arnold M Schwartz,Donald E Henson
Arnold M Schwartz
Molecular Profiling of Clear Cell Myoepithelial Carcinoma of Salivary Glands With EWSR1 Rearrangement Identifies Frequent PLAG1 Gene Fusions But No EWSR1 Fusion Transcripts [0.03%]
具有EWSR1重排的唾液腺透明细胞肌上皮癌的分子谱分析确定了PLAG1基因融合，但没有发现EWSR1融合转录本
Alena Skálová,Abbas Agaimy,Tomas Vanecek et al.
Alena Skálová et al.
Myoepithelial carcinoma of salivary glands is an underrecognized and challenging entity with a broad morphologic spectrum, including an EWSR1-rearranged clear cell variant. Myoepithelial carcinoma is generally aggressive with largely unknow...
SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction [0.03%]
食管和胃食管交界处缺乏SMARCA4/SMARCA2的癌病变
Rachel K Horton,Mahsa Ahadi,Anthony J Gill et al.
Rachel K Horton et al.
Undifferentiated carcinoma of the esophagus and gastroesophageal junction is a recently recognized entity in the fifth edition of the World Health Organization Classification of Digestive Tumors and is diagnostically challenging, particular...
SRF Fusions Other Than With RELA Expand the Molecular Definition of SRF-fused Perivascular Tumors [0.03%]
除与RELA融合外，SRF融合扩展了周围血管肿瘤的分子定义
Marie Karanian,Anna Kelsey,Sandrine Paindavoine et al.
Marie Karanian et al.
Pericytic tumors encompass several entities sharing morphologic and immunohistochemical features. A subset of perivascular myoid tumors associated with the SRF-RELA fusion gene was previously described. Herein, we report a series of 13 tumo...
Molecularly Classified Uterine FIGO Grade 3 Endometrioid Carcinomas Show Distinctive Clinical Outcomes But Overlapping Morphologic Features [0.03%]
分子分类的子宫FIGO三级内膜样癌显示出不同的临床结果但有重叠的形态特征
Amy Joehlin-Price,Jessica Van Ziffle,Nancy K Hills et al.
Amy Joehlin-Price et al.
FIGO grade 3 endometrioid endometrial carcinoma (EEC) is a heterogenous group of tumors with variable molecular and clinicopathologic characteristics but is treated clinically as a single entity. There is a need for additional objective mar...
Molecular Profiling of Salivary Oncocytic Mucoepidermoid Carcinomas Helps to Resolve Differential Diagnostic Dilemma With Low-grade Oncocytic Lesions [0.03%]
唾液腺嗜酸细胞黏液表皮样癌的分子谱分析有助于解决与低级别嗜酸 cell病变的鉴别诊断困境
Alena Skálová,Abbas Agaimy,Olga Stanowska et al.
Alena Skálová et al.
Oncocytic mucoepidermoid carcinoma (OMEC) is a rare but diagnostically challenging variant of mucoepidermoid carcinoma (MEC). OMEC is notable for differential diagnostic considerations that are raised as a result of overlap with other benig...
Histopathologic Characterization of Bladder Perivascular Epithelioid Cell Neoplasms (PEComa): A Series of 11 Cases With a Subset Having TFE3 Rearrangements [0.03%]
膀胱周围血管上皮样细胞肿瘤(PEComa)的组织病理学特征：11例系列病例，其中一部分具有TFE3重排
Neil M Neumann,Michael C Haffner,Pedram Argani et al.
Neil M Neumann et al.
Perivascular epithelioid cell neoplasms (PEComas) of the bladder are extremely rare, with ~30 case reports. A subset of PEComas contain TFE3 gene rearrangement, however, the distinct histomorphologic features of these translocation tumors h...
Masson Trichrome and Sulfated Alcian Blue Stains Distinguish Light Chain Deposition Disease From Amyloidosis in the Lung [0.03%]
马松三重染色和硫酸阿辛蓝染色区分肺轻链沉积病与淀粉样变性病
Shajo Kunnath-Velayudhan,Brandon T Larsen,Shana M Coley et al.
Shajo Kunnath-Velayudhan et al.
Light chain deposition disease, characterized by nonamyloidogenic deposits of immunoglobulin light chains, is rare in the lung and possibly underdiagnosed due to low clinical suspicion and lack of readily accessible tests. We encountered a ...
Nonkeratinizing Squamous Cell Carcinoma of the Sinonasal Tract With DEK-AFF2: Further Solidifying an Emerging Entity [0.03%]
鼻副鼻窦腔非角化性鳞状细胞癌伴DEK-AFF2融合基因：进一步确立的一个新兴类型
Justin A Bishop,Jeffrey Gagan,Claire Paterson et al.
Justin A Bishop et al.