Comparison of biomarkers of oxidative stress and cardiovascular disease in humans and chimpanzees (Pan troglodytes) [0.03%]
人类和黑猩猩（潘特罗格迪斯）的氧化应激和心血管疾病生物标志物比较
Elaine N Videan,Christopher B Heward,Kajal Chowdhury et al.
Elaine N Videan et al.
In the oxidative stress hypothesis of aging, the aging process is the result of cumulative damage by reactive oxygen species. Humans and chimpanzees are remarkably similar; but humans live twice as long as chimpanzees and therefore are beli...
Comparative Study
Comparative medicine. 2009 Jun;59(3):287-96. DOI: 2009
Anna B Roehl,Paul Steendijk,Jan H Baumert et al.
Anna B Roehl et al.
Large animal models for acute pulmonary hypertension (PHT) show distinct differences between species and underlying mechanisms. Two embolic procedures and continuous infusion of a stable thromboxane A(2) analogue (U46619) were explored for ...
Comparative Study
Comparative medicine. 2009 Jun;59(3):280-6. DOI: 2009
Left ventricular remodeling after myocardial infarction: characterization of a swine model on beta-blocker therapy [0.03%]
β受体阻滞剂治疗情况下心肌梗死后左室重构的猪模型研究
Franca S Angeli,Mia Shapiro,Nicolas Amabile et al.
Franca S Angeli et al.
Current guidelines recommend beta blockers for patients after myocardial infarction (MI). Novel therapies for heart failure should be tested in combination with this medication before entering clinical trials. In this methodologic study, we...
Assessing anticalcification treatments in bioprosthetic tissue by using the New Zealand rabbit intramuscular model [0.03%]
新西兰兔肌肉内模型评价生物心脏瓣膜抗钙化处理效果
Gregory A Wright,Joelle M Faught,Jane M Olin
Gregory A Wright
The objective of this work was to demonstrate that the New Zealand White (NZW) rabbit intramuscular model can be used for detecting calcification in bioprosthetic tissue and to compare the calcification in the rabbit to that of native human...
Comparative Study
Comparative medicine. 2009 Jun;59(3):266-71. DOI: 2009
The physiologic responses of Dutch belted rabbits infected with inhalational anthrax [0.03%]
荷兰虎兔感染吸入性炭疽的生理反应
William S Lawrence,Jason M Hardcastle,Douglas L Brining et al.
William S Lawrence et al.
Bacillus anthracis, the causative agent of anthrax, is a category A priority pathogen that causes extensive damage in humans. For this reason, B. anthracis has been the focus of numerous studies using various animal models. In this study, w...
The unilateral urogenital anomalies (UUA) rat: a new mutant strain associated with unilateral renal agenesis, cryptorchidism, and malformations of reproductive organs restricted to the left side [0.03%]
单侧泌尿生殖系异常大鼠品系：与单侧肾缺如、隐睾及左侧生殖器官畸形有关的新突变品系
Kohei Amakasu,Katsushi Suzuki,Hiroetsu Suzuki
Kohei Amakasu
We established an inbred rat strain with unilateral urogenital anomalies from an incidentally identified male rat with unilateral renal agenesis and an undescended left testis. These rats were characterized by unilateral renal agenesis in b...
Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism [0.03%]
利用喂饲脂肪的大鼠来研究肥胖和β肾上腺素能抗药的代谢及血管方面的后果
Melinda Frye,Ivan McMurtry,E Christopher Orton et al.
Melinda Frye et al.
Obesity-associated cardiovascular disease exerts profound human and monetary costs, creating a mounting need for cost-effective and relevant in vivo models of the complex metabolic and vascular interrelationships of obesity. Obesity is asso...
Endpoints for mouse abdominal tumor models: refinement of current criteria [0.03%]
小鼠腹腔肿瘤模型的终点指标优化研究
Eden V Paster,Kimberly A Villines,Debra L Hickman
Eden V Paster
Accurate, rapid, and noninvasive health assessments are required to establish more appropriate endpoints in mouse cancer models where tumor size is not easily measured. We evaluated potential endpoints in mice with experimentally induced pe...
Moxidectin toxicity in senescence-accelerated prone and resistant mice [0.03%]
莫西菌素在早老性易患和抗病小鼠中的毒性作用
Vanessa K Lee,Asheesh K Tiwary,Prachi Sharma-Reddy et al.
Vanessa K Lee et al.
Moxidectin has been used safely as an antiparasitic in many animal species, including for the eradication of the mouse fur mite, Mycoptes musculinus. Although no side effects of moxidectin have previously been reported to occur in mice, 2 s...
Deletion of mitogen-activated protein kinase phosphatase 1 modifies the response to mechanical bone marrow ablation in a mouse model [0.03%]
在小鼠骨髓辐射模型中通过敲除丝裂原活化蛋白激酶磷酸酶1改变对机械性骨髓消融的应答
Jodi Carlson,Qing Zhang,Anton Bennett et al.
Jodi Carlson et al.
The maintenance of bone mass results from a delicate balance between bone formation by osteoblasts and bone resorption by osteoclasts. Understanding these processes is essential for the development of effective treatments for skeletal disea...