Longitudinal Monitoring of Progressive Supranuclear Palsy using Body-Worn Movement Sensors [0.03%]
基于身体佩戴式运动传感器的进行性核上性麻痹纵向监测研究
Charalampos Sotirakis,Niall Conway,Zi Su et al.
Charalampos Sotirakis et al.
Background: We have previously shown that wearable technology and machine learning techniques can accurately discriminate between progressive supranuclear palsy (PSP), Parkinson's disease, and healthy controls. To date th...
Bi-Allelic COQ4 Variants Cause Adult-Onset Ataxia-Spasticity Spectrum Disease [0.03%]
COQ4双等位基因变异导致成年发病的共济失调-痉挛性疾病谱系
Isabell Cordts,Luisa Semmler,Jannik Prasuhn et al.
Isabell Cordts et al.
Background: COQ4 codes for a mitochondrial protein required for coenzyme Q10 (CoQ10 ) biosynthesis. Autosomal recessive COQ4-associated CoQ10 deficiency leads to an early-onset mitochondrial multi-organ disorder. ...
Concerns About the European Academy's Recommendations and Guidelines Regarding Pallidotomy for Parkinson's Disease [0.03%]
对欧洲学院关于帕金森病苍白球毁损的建议和指导原则的思考
Marwan Hariz,Jeff M Bronstein,G Rees Cosgrove et al.
Marwan Hariz et al.
Digital Gait Biomarkers Allow to Capture 1-Year Longitudinal Change in Spinocerebellar Ataxia Type 3 [0.03%]
数字步态生物标志物可捕获第三种脊髓小脑共济失调一年纵向变化
Winfried Ilg,Björn Müller,Jennifer Faber et al.
Winfried Ilg et al.
Measures of step variability and body sway during gait have shown to correlate with clinical ataxia severity in several cross-sectional studies. However, to serve as a valid progression biomarker, these gait measures have to prove their sen...
High-Contrast Imaging of α-Synuclein Pathologies in Living Patients with Multiple System Atrophy [0.03%]
高对比度成像用于活体多系统萎缩患者的α-突触核蛋白病理检测
Kiwamu Matsuoka,Maiko Ono,Yuhei Takado et al.
Kiwamu Matsuoka et al.
Diffusion Magnetic Resonance Imaging Microstructural Abnormalities in Multiple System Atrophy: A Comprehensive Review [0.03%]
系统性萎缩弥散张量磁共振成像微结构异常的综合述评
Jacopo Pasquini,Michael J Firbank,Roberto Ceravolo et al.
Jacopo Pasquini et al.
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by autonomic failure, ataxia, and/or parkinsonism. Its prominent pathological alterations can be investigated using diffusion magnetic resonance imaging (dMRI), a te...
Targeted Molecular Therapeutics for Parkinson's Disease: A Role for Antisense Oligonucleotides? [0.03%]
针对帕金森病的分子靶向治疗：反义寡核苷酸的作用？
Dunhui Li,Frank L Mastaglia,Wai Yan Yau et al.
Dunhui Li et al.
Magnetic Resonance-Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early-Stage Tremor-Dominant Parkinson's Disease: A Pilot Study [0.03%]
磁共振引导的聚焦超声丘脑毁损术可能使震颤型帕金森病患者在早期阶段免于多巴胺能治疗：一项初步研究
Nico Golfrè Andreasi,Roberto Cilia,Luigi Michele Romito et al.
Nico Golfrè Andreasi et al.
Background: Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD). ...
Family History for Neurodegeneration in Multiple System Atrophy: Does it Indicate Susceptibility? [0.03%]
多系统萎缩家族史与易感性关系的临床研究
Fabian Leys,Sabine Eschlböck,Nicole Campese et al.
Fabian Leys et al.