Identifying Protective Drugs for Parkinson's Disease in Health-Care Databases Using Machine Learning [0.03%]
利用机器学习在医疗数据库中识别帕金森病的保护性药物
Émeline Courtois,Thi Thu Ha Nguyen,Agnès Fournier et al.
Émeline Courtois et al.
Background: Available treatments for Parkinson's disease (PD) are only partially or transiently effective. Identifying existing molecules that may present a therapeutic or preventive benefit for PD (drug repositioning) is...
The Genetic Landscape of Complex Childhood-Onset Hyperkinetic Movement Disorders [0.03%]
复杂型儿童期起病的运动过多症的基因组景观
Belén Pérez-Dueñas,Kathleen Gorman,Anna Marcé-Grau et al.
Belén Pérez-Dueñas et al.
Background and objective: The objective of this study was to better delineate the genetic landscape and key clinical characteristics of complex, early-onset, monogenic hyperkinetic movement disorders. ...
Effect of Opicapone on Levodopa Pharmacokinetics in Patients with Fluctuating Parkinson's Disease [0.03%]
Opicapone对波动性帕金森病患者左旋多巴药代动力学的影响
Joaquim J Ferreira,Werner Poewe,Olivier Rascol et al.
Joaquim J Ferreira et al.
Background: Inhibiting catechol-O-methyltransferase extends the plasma half-life of levodopa, potentially allowing physicians to optimize the levodopa regimen in patients with Parkinson's disease (PD) experiencing motor f...
Randomized Controlled Trial
Movement disorders : official journal of the Movement Disorder Society. 2022 Nov;37(11):2272-2283. DOI:10.1002/mds.29193 2022
A Machine Learning-Based Approach to Discrimination of Tauopathies Using [18 F]PM-PBB3 PET Images [0.03%]
基于机器学习的 tau 病分类方法：使用[18F]PM-PBB3 影像
Hironobu Endo,Kenji Tagai,Maiko Ono et al.
Hironobu Endo et al.
Background: We recently developed a positron emission tomography (PET) probe, [18 F]PM-PBB3, to detect tau lesions in diverse tauopathies, including mixed three-repeat and four-repeat (3R + 4R) tau fibrils in Alzheimer's ...
Specific Gait Changes in Prodromal Hereditary Spastic Paraplegia Type 4: preSPG4 Study [0.03%]
SPG4型遗传性痉挛性截瘫前期的步态变化：preSPG4研究
Christian Laßmann,Winfried Ilg,Marc Schneider et al.
Christian Laßmann et al.
Background: In hereditary spastic paraplegia type 4 (SPG4), subclinical gait changes might occur years before patients realize gait disturbances. The prodromal phase of neurodegenerative disease is of particular interest ...
Stereotyped Relationship Between Motor and Cognitive Metabolic Networks in Parkinson's Disease [0.03%]
帕金森病中运动和认知代谢网络的刻板相关性
Tomaž Rus,Katharina A Schindlbeck,Chris C Tang et al.
Tomaž Rus et al.
Background: Idiopathic Parkinson's disease (iPD) is associated with two distinct brain networks, PD-related pattern (PDRP) and PD-related cognitive pattern (PDCP), which correlate respectively with motor and cognitive sym...
Differences in Sex-Specific Frequency of Glucocerebrosidase Variant Carriers and Familial Parkinsonism [0.03%]
GBA突变携带者中帕金森病的性别差异研究进展
Roberto A Ortega,Susan B Bressman,Deborah Raymond et al.
Roberto A Ortega et al.
Background: Although men and women with the LRRK2 G2019S variant appear to be equally likely to have Parkinson's disease (PD), the sex-distribution among glucocerebrosidase (GBA) variant carriers with PD, including limite...
Altered Medial Prefrontal Connectivity in Parkinson's Disease Patients with Somatic Symptoms [0.03%]
帕金森病患者躯体症状的内侧前额叶连接异常
Stefano Delli Pizzi,Raffaella Franciotti,Piero Chiacchiaretta et al.
Stefano Delli Pizzi et al.
Background: The high co-occurrence of somatic symptom disorder (SSD) in Parkinson's disease (PD) patients suggests overlapping pathophysiology. However, little is known about the neural correlates of SSD and their possibl...
Sensitivity of Sniffer Dogs for a Diagnosis of Parkinson's Disease: A Diagnostic Accuracy Study [0.03%]
嗅探犬诊断帕金森病的灵敏度：一项诊断准确性研究
Chang-Qing Gao,Shan-Ni Wang,Mei-Mei Wang et al.
Chang-Qing Gao et al.
Background: The diagnostic criteria for Parkinson's disease (PD) remain complex, which is especially problematic for nonmovement disorder experts. A test is required to establish a diagnosis of PD with improved accuracy a...
Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration [0.03%]
细颗粒物诱导α-突触核蛋白纤维化并引发类似帕金森病的神经退行性病变
Xin Yuan,Yingxu Yang,Chaoyang Liu et al.
Xin Yuan et al.
Background: The deposition of α-synuclein (α-Syn) in the brain is the pathological hallmark of Parkinson's disease (PD). Epidemiological data indicate that exposure to fine particulate matter (≤2.5 μm in aerodynamic d...