Serotonin Transporter Imaging in Multiple System Atrophy and Parkinson's Disease [0.03%]
多系统萎缩和帕金森病中的血清素转运蛋白显像
Kelvin L Chou,Praveen Dayalu,Robert A Koeppe et al.
Kelvin L Chou et al.
Background: Both Parkinson's disease (PD) and multiple system atrophy (MSA) exhibit degeneration of brainstem serotoninergic nuclei, affecting multiple subcortical and cortical serotoninergic projections. In MSA, medullar...
Putaminal Recombinant Glucocerebrosidase Delivery with Magnetic Resonance-Guided Focused Ultrasound in Parkinson's Disease: A Phase I Study [0.03%]
磁共振引导聚焦超声递送纹状体重组葡糖脑苷脂酶治疗帕金森病一期临床试验
Ying Meng,Christopher B Pople,Yuexi Huang et al.
Ying Meng et al.
Background: GBA1 mutation is the most common genetic risk factor for Parkinson's disease (PD). Replacement of the lysosomal enzyme glucocerebrosidase (GCase) slows neurodegeneration in PD models and may be a promising dis...
Joint Modeling Study Identifies Blood-Based Transcripts Link to Cognitive Decline in Parkinson's Disease [0.03%]
联合建模研究识别出与帕金森病认知衰退相关的血液转录物标志物
Junfeng Luo,Hao Wu,Jinxia Li et al.
Junfeng Luo et al.
Background: Cognitive decline in Parkinson's disease (PD) is prevalent, insidious, and burdensome during the progression of the disease. Objectives: ...
Homozygous CADPS2 Mutations Cause Neurodegenerative Disease with Lewy Body-like Pathology in Parrots [0.03%]
CADPS2同合子突变导致鹦鹉类似路易小体的神经退行性疾病
Oswaldo Lorenzo-Betancor,Livio Galosi,Laura Bonfili et al.
Oswaldo Lorenzo-Betancor et al.
Background: Several genetic models that recapitulate neurodegenerative features of Parkinson's disease (PD) exist, which have been largely based on genes discovered in monogenic PD families. However, spontaneous genetic m...
The Unified Multiple System Atrophy Rating Scale: Status, Critique, and Recommendations [0.03%]
统一多系统萎缩量表：现状、批评和建议
Florian Krismer,Jose-Alberto Palma,Giovanna Calandra-Buonaura et al.
Florian Krismer et al.
Diet Quality is Associated with Prodromal Parkinson's Disease Features in Chinese Adults [0.03%]
饮食质量与中国成年人帕金森病前驱期特征有关
Xinyuan Zhang,Jipo Xu,Yesong Liu et al.
Xinyuan Zhang et al.
Background: The prodromal phase of Parkinson's disease (PD) is a critical window for prevention by modifying lifestyle factors. However, there is limited knowledge on how diet quality is associated with prodromal PD sympt...
No Association Between Rare TWNK Variants and Parkinson's Disease in European Cohorts [0.03%]
罕见TWINKL变异与欧洲队列帕金森病无相关性
Konstantin Senkevich,Ziv Gan-Or
Konstantin Senkevich
Fatemeh Seifar,Ashok R Dinasarapu,H A Jinnah
Fatemeh Seifar
Numerous studies have linked Parkinson's disease (PD) with low levels of uric acid (UA). Low UA has been associated with the risk of developing PD, and its progression and severity. The biological mechanisms underlying these relationships h...
Jacob E Simmering,Michael J Welsh,Jordan Schultz et al.
Jacob E Simmering et al.
Background: Terazosin (TZ) and closely related α1-adrenergic receptor antagonists (doxazosin [DZ] and alfuzosin [AZ]) enhance glycolysis and reduce neurodegeneration in animal models. Observational evidence in humans fro...