Salivary α-Synuclein RT-QuIC Correlates with Disease Severity in de novo Parkinson's Disease [0.03%]
新型帕金森病患者的唾液α-突触核蛋白RT-QUIC与疾病严重程度相关性研究
Giorgio Vivacqua,Matthew Mason,Maria Ilenia De Bartolo et al.
Giorgio Vivacqua et al.
Therapeutic Misestimation in Patients with Degenerative Ataxia: Lessons from a Randomized Controlled Trial [0.03%]
遗传性小脑萎缩患者治疗过度乐观现象：一项随机对照试验的启示
Roderick P P W M Maas,Bart P C van de Warrenburg
Roderick P P W M Maas
Background: The absence of effective treatments may render patients with degenerative cerebellar ataxias susceptible to a placebo response, which could affect the outcome of clinical trials. ...
Randomized Controlled Trial
Movement disorders : official journal of the Movement Disorder Society. 2023 Jan;38(1):133-137. DOI:10.1002/mds.29252 2023
Ambulatory Detection of Isolated Rapid-Eye-Movement Sleep Behavior Disorder Combining Actigraphy and Questionnaire [0.03%]
结合活动记录仪和问卷检测快速眼球运动睡眠行为障碍
Andreas Brink-Kjaer,Niraj Gupta,Eric Marin et al.
Andreas Brink-Kjaer et al.
Background: Isolated rapid-eye-movement sleep behavior disorder (iRBD) is in most cases a prodrome of neurodegenerative synucleinopathies, affecting 1% to 2% of middle-aged and older adults; however, accurate ambulatory d...
(Dis-)Connected Dots in Dementia with Lewy Bodies-A Systematic Review of Connectivity Studies [0.03%]
弥漫性路易体痴呆的连接研究系统的文献综述：零散的知识点及其联系
Annegret Habich,Lars-Olof Wahlund,Eric Westman et al.
Annegret Habich et al.
Studies on dementia with Lewy bodies (DLB) have mainly focused on the degeneration of distinct cortical and subcortical regions related to the deposition of Lewy bodies. In view of the proposed trans-synaptic spread of the α-synuclein path...
Increased Free Water in the Substantia Nigra in Asymptomatic LRRK2 G2019S Mutation Carriers [0.03%]
无症状LRRK2(G2019S)突变携带者黑质区自由水增加
Dongling Zhang,Liche Zhou,Yuting Shi et al.
Dongling Zhang et al.
Background: The alteration of substantia nigra (SN) degeneration in populations at risk of Parkinson's disease (PD) is unclear. Objective: ...
Brain Metabolic Correlates of Dopaminergic Denervation in Prodromal and Early Parkinson's Disease [0.03%]
早发帕金森病的多巴胺能脱失的脑代谢相关因素
Ryul Kim,Heejung Kim,Yu Kyeong Kim et al.
Ryul Kim et al.
Background: It remains unclear how brain metabolic activities transform in response to dopamine deficiency in the prodromal and early phases of Parkinson's disease (PD). ...
Reply to: "Low Frequency of p.S510G in PIAS1 Challenges Its Relevance for Modifying Repeat Expansion Disorders" [0.03%]
对“PIAS1中p.S510G等位基因频率较低对其修饰重复扩张障碍的相关性提出挑战”的回复
Yan Hua Lee,Yi-Chung Lee,Yu-Shuen Tsai et al.
Yan Hua Lee et al.
Split-Belt Treadmill Training to Improve Gait Adaptation in Parkinson's Disease [0.03%]
分带式跑步机训练改善帕金森病步态适应性的研究
Femke Hulzinga,Jana Seuthe,Nicholas D&#x;Cruz et al.
Femke Hulzinga et al.
Background: Gait deficits in people with Parkinson's disease (PD) are triggered by circumstances requiring gait adaptation. The effects of gait adaptation training on a split-belt treadmill (SBT) are unknown in PD. ...
Randomized Controlled Trial
Movement disorders : official journal of the Movement Disorder Society. 2023 Jan;38(1):92-103. DOI:10.1002/mds.29238 2023
Suitability of Automated Writing Measures for Clinical Trial Outcome in Writer's Cramp [0.03%]
自动化写作测量方法用于痉挛书写症临床试验结局的可行性研究
Noreen Bukhari-Parlakturk,Michael W Lutz,Hussein R Al-Khalidi et al.
Noreen Bukhari-Parlakturk et al.
Background: Writer's cramp (WC) dystonia is a rare disease that causes abnormal postures during the writing task. Successful research studies for WC and other forms of dystonia are contingent on identifying sensitive and ...
Adult-Onset Neurodegeneration in Nucleotide Excision Repair Disorders: More Common than Expected [0.03%]
核苷酸切除修复紊乱中的成人期神经退行性病变：比预期的更为常见
Matej Skorvanek,Janette Baloghova,Kristina Kulcsarova et al.
Matej Skorvanek et al.