Clinical Diagnostic Accuracy of Parkinson's Disease: Where Do We Stand? [0.03%]
帕金森病的临床诊断准确性：我们目前处于什么位置？
Sasivimol Virameteekul,Tamas Revesz,Zane Jaunmuktane et al.
Sasivimol Virameteekul et al.
Background: Clinical diagnostic accuracy of Parkinson's disease (PD) remains suboptimal. Changes in disease concept may have improved clinical diagnostic accuracy in the past decade. However, current clinical diagnostic c...
Classification of GBA1 Variants in Parkinson's Disease: The GBA1-PD Browser [0.03%]
GBA1变异在帕金森病中的分类：GBA1-PD浏览器
Sitki Cem Parlar,Francis P Grenn,Jonggeol Jeffrey Kim et al.
Sitki Cem Parlar et al.
Background: GBA1 variants are among the most common genetic risk factors for Parkinson's disease (PD). GBA1 variants can be classified into three categories based on their role in Gaucher's disease (GD) or PD: severe, mil...
Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta [0.03%]
易感性磁共振成像与致密部黑质中少突胶质细胞密度和tau的相关性研究
Ernest W Wang,Gregory L Brown,Mechelle M Lewis et al.
Ernest W Wang et al.
Background: Susceptibility magnetic resonance imaging (MRI) is sensitive to iron-related changes in the substantia nigra pars compacta (SNc), the key pathologic locus of parkinsonisms. It is unclear, however, if iron depo...
Cholinergic Nucleus 4 Degeneration and Cognitive Impairment in Isolated Rapid Eye Movement Sleep Behavior Disorder [0.03%]
孤立的快速眼动睡眠行为障碍中的乙酰胆碱能核团4退化和认知损伤
Christopher Tan,Huma Nawaz,Sarah K Lageman et al.
Christopher Tan et al.
Background: Cholinergic nucleus 4 (Ch4) degeneration is associated with cognitive impairment in Parkinson's disease and dementia with Lewy bodies, but it is unknown if Ch4 degeneration is also present in isolated rapid ey...
Neuromelanin-Sensitive Magnetic Resonance Imaging Changes in the Locus Coeruleus/Subcoeruleus Complex in Patients with Typical and Atypical Parkinsonism [0.03%]
典型和非典型帕金森病患者蓝斑/下蓝斑复合体神经黑素敏感的磁共振成像变化
Alexis Nobileau,Rahul Gaurav,Lydia Chougar et al.
Alexis Nobileau et al.
Background: The locus coeruleus/subcoeruleus complex (LC/LsC) is a structure comprising melanized noradrenergic neurons. Objective: To ...
Using Downgaze Palsy Progression Rate to Model Survival in Progressive Supranuclear Palsy-Richardson Syndrome [0.03%]
利用下视麻痹进展速率建模进行眼肌瘫痪里查德森综合征的生存率预测
Tao Xie,Anne-Marie Wills,Chuanhong Liao et al.
Tao Xie et al.
Background: Rapid development of downgaze palsy, the most specific symptom of progressive supranuclear palsy (PSP), has been associated with shorter survival in small studies. ...
Diagnosis and Outcomes of Late-Onset Wilson's Disease: A National Registry-Based Study [0.03%]
成人发病的威尔逊氏症的诊断和结果：一项基于全国病例登记的研究
Christelle Nilles,Mickael Alexandre Obadia,Rodolphe Sobesky et al.
Christelle Nilles et al.
Background: Wilson's disease (WD) is usually diagnosed in children and young adults; limited data exist on late-onset forms. Objective: ...
Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts [0.03%]
二型糖尿病与帕金森病：当前概念的专题回顾
Patrick W Cullinane,Eduardo de Pablo Fernandez,Annekatrin König et al.
Patrick W Cullinane et al.
Highly reproducible epidemiological evidence shows that type 2 diabetes (T2D) increases the risk and rate of progression of Parkinson's disease (PD), and crucially, the repurposing of certain antidiabetic medications for the treatment of PD...
Subthalamic Nucleus Stimulation-Induced Local Field Potential Changes in Dystonia [0.03%]
下丘脑核刺激在 dystonia 中引起的局部场电位变化
Christoph Wiest,Francesca Morgante,Flavie Torrecillos et al.
Christoph Wiest et al.
Background: Subthalamic nucleus (STN) stimulation is an effective treatment for Parkinson's disease and induced local field potential (LFP) changes that have been linked with clinical improvement. STN stimulation has also...
Reduced D2 /D3 Receptor Binding and Glucose Metabolism in a Macaque Model of Huntington's Disease [0.03%]
亨廷顿病恒河猴模型中降低的D2/D3受体结合和葡萄糖代谢
Alison R Weiss,Daniele Bertoglio,William A Liguore et al.
Alison R Weiss et al.
Background: Dopamine system dysfunction and altered glucose metabolism are implicated in Huntington's disease (HD), a neurological disease caused by mutant huntingtin (mHTT) expression. ...