Cross-Cultural Differences in Patient Perceptions of Dyskinesia in Parkinson's Disease [0.03%]
帕金森病患者对运动障碍的文化差异感知
Valtteri Kaasinen,Sheng Luo,Pablo Martinez-Martin et al.
Valtteri Kaasinen et al.
Background: The prevalence of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) varies among geographical regions. Cultural differences in patient-based perceptions of LID have not been studied. ...
Dopamine Agonist Cotreatment Alters Neuroplasticity and Pharmacology of Levodopa-Induced Dyskinesia [0.03%]
多巴胺激动剂联合治疗改变左旋多巴引起的异动症的神经可塑性和药理特性
Elena Espa,Lu Song,Katrine Skovgård et al.
Elena Espa et al.
Background: Current models of levodopa (L-dopa)-induced dyskinesia (LID) are obtained by treating dopamine-depleted animals with L-dopa. However, patients with LID receive combination therapies that often include dopamine...
Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting α-Synuclein [0.03%]
谁说过这会很容易？反思两项针对α-突触核蛋白的临床试验
Poul Henning Jensen,Michael G Schlossmacher,Leonidas Stefanis
Poul Henning Jensen
Two recent, high-profile manuscripts reported negative results with two parallel approaches of passive immunization targeting α-synuclein in a population of patients with early Parkinson's disease (PD). These phase II studies failed to sho...
The Genetic Etiology of Parkinson's Disease Does Not Robustly Affect Subthalamic Physiology [0.03%]
帕金森病的遗传病因并未显著影响丘脑底核的生理功能
Caroline Weill,Akiva Gallant,Halen Baker Erdman et al.
Caroline Weill et al.
Background: It is unknown whether Parkinson's disease (PD) genetic heterogeneity, leading to phenotypic and pathological variability, is also associated with variability in the unique PD electrophysiological signature. Su...
Measurement of Pupillary Reward Sensitivity: A Tool for Risk Stratification in Isolated Rapid Eye Movement Behavioral Disorder? [0.03%]
瞳孔奖赏敏感性测量：孤立的快速眼动睡眠行为障碍风险分层的工具？
Ameya Patwardhan,Mario Masellis
Ameya Patwardhan
Using Movement Disorder Society Unified Parkinson's Disease Rating Scale Parts 2 and 3 Simultaneously: Combining the Patient Voice with Clinician Ratings [0.03%]
同时使用运动障碍学会帕金森病评分量表的第2部分和第3部分内容：结合患者声音与临床医生评分
Yuanyuan Guo,Christopher G Goetz,Glenn T Stebbins et al.
Yuanyuan Guo et al.
Background: Regulatory recommendations favor outcomes combining objective and patient input. The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), the most commonly used scale in Parkinson's ...
In Situ Global Structural Proteome Analysis Identifies Potential Biomarkers for Parkinson's Disease [0.03%]
原位全局结构蛋白质组分析鉴定出帕金森氏病的潜在生物标志物
Mohamed Abdelhafeez,Inas Elsayed
Mohamed Abdelhafeez
Pathological Validation of the MDS Criteria for the Diagnosis of Multiple System Atrophy [0.03%]
多系统萎缩诊断MDS标准的病理验证研究
Sasivimol Virameteekul,Tamas Revesz,Zane Jaunmuktane et al.
Sasivimol Virameteekul et al.
Background: The recent International Parkinson and Movement Disorder Society diagnostic criteria for multiple system atrophy (MDS-MSA) have been developed to improve diagnostic accuracy although their diagnostic propertie...
Impaired Metacognition of Voluntary Movement in Functional Movement Disorder [0.03%]
功能性运动障碍中受损的自愿运动元认知能力
Julius Verrel,Fabian Chwolka,Elisa Filevich et al.
Julius Verrel et al.
Background: Motor symptoms in functional movement disorders (FMDs) are experienced as involuntary but share characteristics of voluntary action. Clinical and experimental evidence indicate alterations in monitoring, contr...