Cholinergic System Changes in Dopa-Unresponsive Freezing of Gait in Parkinson's Disease [0.03%]
帕金森病多巴胺无反应性冻结步态的胆碱能系统改变
Kelvin L Chou,Prabesh Kanel,Miriam van Emde Boas et al.
Kelvin L Chou et al.
Background: Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the r...
Decreased Peripheral Blood Lymphocytes in Spinocerebellar Ataxia Type 3 Correlate with Disease Severity [0.03%]
脊髓小脑共济失调 III 型外周血淋巴细胞减少与疾病严重程度相关性研究
Qi Deng,Cuiling Tang,Zhao Chen et al.
Qi Deng et al.
Background: The immune system likely plays a role in the pathogenesis of spinocerebellar ataxia type 3 (SCA3). Peripheral blood leukocytes are indicative of the immune status in neurodegenerative diseases. However, altera...
Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease [0.03%]
沿周血管空间扩散作为亨廷顿舞蹈病淋巴神经系统损害的标志
Jin-Hui Yin,Ling-Xiao Cao,Ya-Ou Liu et al.
Jin-Hui Yin et al.
Background: The aim was to investigate if glymphatic function is impaired in patients with Huntington's disease (HD) and its clinical relevance. Methods: ...
Noninvasive Temporal Interference Stimulation of the Subthalamic Nucleus in Parkinson's Disease Reduces Beta Activity [0.03%]
非侵入性时间干涉刺激纹状体中间核可降低帕金森病的β振荡活动
Martin Lamoš,Martina Bočková,Florian Missey et al.
Martin Lamoš et al.
Background: Temporal interference stimulation (TIS) is a novel noninvasive electrical stimulation technique to focally modulate deep brain regions; a minimum of two high-frequency signals (f1 and f2 > 1 kHz) interfere to ...
Anosmia and Upper Limb Rigidity-A Potential Phenotype of Idiopathic Normal Pressure Hydrocephalus with Cerebrospinal Fluid α-Synuclein Seeds [0.03%]
嗅觉减退和上肢僵硬-idiopathic正常压力脑积水的潜在表型，伴有脑脊液α-突触核蛋白种子
Sandrina Weber,Carly M Farris,Yihua Ma et al.
Sandrina Weber et al.
Background: The pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) and its association with neurodegenerative disorders is poorly understood. ...
Repeat Expansions with Small TTTCA Insertions in MARCHF6 Cause Familial Myoclonus without Epilepsy [0.03%]
MARCHF6基因中微小TTC插入导致的重复序列扩张引起遗传性肌阵挛但不伴癫痫
Theresa Kühnel,Elsa Leitão,Renate Lunzer et al.
Theresa Kühnel et al.
Background: Familial adult myoclonus epilepsy (FAME) is a rare autosomal dominant disorder caused by the same intronic TTTTA/TTTCA repeat expansion in seven distinct genes. TTTTA-only expansions are benign, whereas those ...
Levodopa-An Oldie but a Goodie-Time to Make It Accessible to All in Sub-Saharan Africa [0.03%]
左旋多巴——老药新用，使其在撒哈拉以南非洲普及的时机已经成熟
Indu Subramanian,Njideka Okubadejo,Natasha Fothergill-Misbah
Indu Subramanian
Antero-Lateral Subthalamic Nucleus Theta Stimulation Improves Verbal Fluency in Parkinson's Disease [0.03%]
电刺激副纹状体核改善帕金森病患者的言语流畅度
Hannah Schoenwald,Bahne H Bahners,Silja Kannenberg et al.
Hannah Schoenwald et al.
Objective: Low-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been associated with positive effects on verbal fluency (VF) in patients with Parkinson's disease. This prospective study investig...
Trajectories of Pontine Volume in Patients with Multiple System Atrophy [0.03%]
小脑桥脑池体积在多系统萎缩患者中的变化轨迹
Kazuya Kawabata,Florian Krismer,Mizuki Ito et al.
Kazuya Kawabata et al.
Objectives: To investigate trajectories of regional brain volume changes in multiple system atrophy (MSA) and their potential utility as surrogate markers of disease progression in the cerebellar subtype (MSA-C). ...
Spinal Cord Stimulation Failed to Improve Parkinson's Disease Symptoms in Randomized Crossover Double-Blinded Evaluation [0.03%]
随机交叉双盲评估脊髓刺激未能改善帕金森病症状
Rafael Bernhart Carra,Lucas Ávila Lessa Garcia,Janaina Reis Menezes et al.
Rafael Bernhart Carra et al.
Background: Epidural electrical spinal cord stimulation has been studied for more than a decade for Parkinson's disease symptoms, but compelling evidence for its effectiveness is still lacking. ...