Susceptibility-Weighted Imaging Reveals Subcortical Iron Deposition in PLA2G6-associated Neurodegeneration: The "Double Cortex Sign" [0.03%]
PLA2G6相关神经退行性病变中利用磁敏感加权成像发现铁沉积：双皮层征的揭示
Benjamin Roeben,Lena Zeltner,Gisela E Hagberg et al.
Benjamin Roeben et al.
Redefining Bradykinesia [0.03%]
重新定义运动迟缓
Matteo Bologna,Alberto J Espay,Alfonso Fasano et al.
Matteo Bologna et al.
Duodenal alpha-Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease [0.03%]
帕金森病晚期的十二指肠α-突触核蛋白病理和肠神经胶质细胞增生
Aron Emmi,Michele Sandre,Francesco Paolo Russo et al.
Aron Emmi et al.
Background: The role of the gut-brain axis has been recently highlighted as a major contributor to Parkinson's disease (PD) physiopathology, with numerous studies investigating bidirectional transmission of pathological p...
Long-Duration Response to Levodopa, Motor Learning, and Neuroplasticity in Early Parkinson's Disease [0.03%]
左旋多巴的长期反应、运动学习和早期帕金森病的神经可塑性
Giorgia Sciacca,Giovanni Mostile,Ivano Disilvestro et al.
Giorgia Sciacca et al.
Background: Long-duration response (LDR) to levodopa and motor learning could be involved in changes in neuroplasticity of cortical excitability in Parkinson's disease (PD). P300, motor evoked potentials (MEPs), and Berei...
Effects of Dihydropyridines on the Motor and Cognitive Outcomes of Patients with Parkinson's Disease [0.03%]
二氢吡啶类药物对帕金森病患者运动及认知结果的影响
Jin Ho Jung,Han Kyu Na,Seong Ho Jeong et al.
Jin Ho Jung et al.
Background: Dihydropyridines (DHPs) may have neuroprotective effects against Parkinson's disease (PD). Objective: This study investigat...
Peripheral Inflammation Links with the Severity of Clinical Phenotype in Spinocerebellar Ataxia 2 [0.03%]
外周炎症与脊髓小脑性共济失调2型临床表型严重程度相关性研究
Yaimeé Vázquez-Mojena,Yanetsy Rodríguez-Córdova,Yennis Dominguez-Barrios et al.
Yaimeé Vázquez-Mojena et al.
Background: The role of peripheral inflammation in spinocerebellar ataxia type 2 (SCA2) is unknown. Objective: The objective of this st...
Atrophin-1 Function and Dysfunction in Dentatorubral-Pallidoluysian Atrophy [0.03%]
dentatorubropallidoluysian萎缩蛋白1功能和失调的功能作用
Bartosz Nowak,Emilia Kozlowska,Weronika Pawlik et al.
Bartosz Nowak et al.
Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare, incurable genetic disease that belongs to the group of polyglutamine (polyQ) diseases. DRPLA is the most common in the Japanese population; however, its global prevalence is also incre...
LRRK2 Quantification in Cerebrospinal Fluid of Patients with Parkinson's Disease and Atypical Parkinsonian Syndromes [0.03%]
帕金森病和非典型性帕金森综合征患者脑脊液中LRRK2含量测定
Andrea Mancini,Erik Stoops,Leentje Demeyer et al.
Andrea Mancini et al.
Background: The alteration of leucine-rich repeat kinase 2 (LRRK2) kinase activity is thought to be involved in Parkinson's disease (PD) pathogenesis beyond familiar cases, and LRRK2 inhibitors are currently under investi...
Pallidal Beta Activity Is Linked to Stimulation-Induced Slowness in Dystonia [0.03%]
苍白球β电活动与扭转痉挛患者的刺激诱导的缓慢性有关
Roxanne Lofredi,Ute Scheller,Aurika Mindermann et al.
Roxanne Lofredi et al.
Background: Pallidal deep brain stimulation (DBS) effectively alleviates symptoms in dystonia patients, but may induce movement slowness as a side-effect. In Parkinson's disease, hypokinetic symptoms have been associated ...
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease [0.03%]
帕金森病健康受试者和患者中BIIB122抑制LRRK2的I期研究
Danna Jennings,Sarah Huntwork-Rodriguez,Maurits F J M Vissers et al.
Danna Jennings et al.
Background: Leucine-rich repeat kinase 2 (LRRK2) inhibition is a promising therapeutic approach for the treatment of Parkinson's disease (PD). Objective: ...