Günther Deuschl,Angelo Antonini,Joao Costa et al.
Günther Deuschl et al.
Long-Term Intake of Folate, Vitamin B6, and Vitamin B12 and the Incidence of Parkinson's Disease in a Sample of U.S. Women and Men [0.03%]
叶酸、维生素B6和维生素B12的长期摄入与美国男女帕金森病发病率的关系
Mario H Flores-Torres,Chadwick W Christine,Kjetil Bjornevik et al.
Mario H Flores-Torres et al.
Background: Folate and vitamins B6 and B12 have been proposed as protective against the development of Parkinson's disease (PD). Two prior longitudinal studies were inconclusive. ...
A Novel Metric for Predicting Severity of Disease Features in Friedreich's Ataxia [0.03%]
预测弗里德赖希共济失调疾病特征严重程度的新指标
Layne N Rodden,Christian Rummey,Sudha Kessler et al.
Layne N Rodden et al.
Background: Friedreich's ataxia (FRDA), most commonly caused by a GAA triplet repeat (GAA-TR) expansion in intron 1 of the FXN gene, is characterized by deficiency of frataxin protein and clinical features such as progres...
A Biomarker Study in Patients with GBA1-Parkinson's Disease and Healthy Controls [0.03%]
GBA1帕金森病患者与健康对照的生物标志物研究
Jonas M den Heijer,Valerie C Cullen,Diana R Pereira et al.
Jonas M den Heijer et al.
Background: Molecules related to glucocerebrosidase (GCase) are potential biomarkers for development of compounds targeting GBA1-associated Parkinson's disease (GBA-PD). ...
Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease [0.03%]
外周炎症与帕金森病多巴胺能变性相关
Laura Muñoz-Delgado,Miguel Ángel Labrador-Espinosa,Daniel Macías-García et al.
Laura Muñoz-Delgado et al.
Background: Peripheral inflammatory immune responses are suggested to play a major role in dopaminergic degeneration in Parkinson's disease (PD). The neutrophil-to-lymphocyte ratio (NLR) is a well-established biomarker of...
Synaptic Density and Glucose Consumption in Patients with Lewy Body Diseases: An [11 C]UCB-J and [18 F]FDG PET Study [0.03%]
路易体疾病患者的突触密度和葡萄糖消耗：[11C]UCB-J 和 [18F]FDG 彭特研究
Katrine B Andersen,Allan K Hansen,Anna Christina Schacht et al.
Katrine B Andersen et al.
Background: Patients with Lewy body diseases exhibit variable degrees of cortical and subcortical hypometabolism. However, the underlying causes behind this progressive hypometabolism remain unresolved. Generalized synapt...
Insights into Neurodegeneration in Parkinson's Disease from Single-Cell and Spatial Genomics [0.03%]
单细胞和空间组学揭示帕金森病神经退行性病变的机制
Tushar Kamath,Evan Z Macosko
Tushar Kamath
Parkinson's disease (PD) is pathologically defined by the death of dopaminergic (DA) neurons within the pars compacta of the substantia nigra. To date, the cause of this multifaceted disease remains largely unclear, which may contribute in ...
E Ray Dorsey,Amit Ray
E Ray Dorsey
Polygenic Parkinson's Disease Genetic Risk Score as Risk Modifier of Parkinsonism in Gaucher Disease [0.03%]
格肖病患者中帕金森病多基因遗传风险评分对帕金森综合征的修饰作用
Cornelis Blauwendraat,Nahid Tayebi,Elizabeth Geena Woo et al.
Cornelis Blauwendraat et al.
Background: Biallelic pathogenic variants in GBA1 are the cause of Gaucher disease (GD) type 1 (GD1), a lysosomal storage disorder resulting from deficient glucocerebrosidase. Heterozygous GBA1 variants are also a common ...
Talene A Yacoubian,Yu-Hua Dean Fang,Adam Gerstenecker et al.
Talene A Yacoubian et al.
Objective: To assess the presence of brain and systemic inflammation in subjects newly diagnosed with Parkinson's disease (PD). Background: ...