Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein [0.03%]
Venglustat的双重效应：对α-突触核蛋白过表达小鼠的行为和病理学的影响
Alina Schidlitzki,Milos Stanojlovic,Céline Fournier et al.
Alina Schidlitzki et al.
Background: Venglustat is a brain-penetrant, small molecule inhibitor of glucosylceramide synthase used in clinical testing for treatment of Parkinson's disease (PD). Despite beneficial effects in certain cellular and rod...
The Views of Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder on Risk Disclosure [0.03%]
快速眼动睡眠行为障碍患者的风险披露观点
Laura Pérez-Carbonell,Cristina Simonet,Harneek Chohan et al.
Laura Pérez-Carbonell et al.
Background: Isolated rapid eye movement sleep behavior disorder (iRBD) is associated with an increased risk of Parkinson's disease and other synucleinopathies. There is no consensus about disclosure of this risk to patien...
High Frequency of LRRK2 R1441C Pathogenic Variant Among Palestinian-Arabs [0.03%]
帕勒斯坦阿拉伯人中LRRK2 R1441C致病突变的高检出率
Muneer Abu Snineh,Roy Dayan,Rivka Birnbaum et al.
Muneer Abu Snineh et al.
Cross-Ethnic Variant Screening and Burden Analysis of PTPA in Parkinson's Disease [0.03%]
帕金森病跨种族PTPA基因变异筛查及负荷分析
Chunyu Li,Junyu Lin,Qirui Jiang et al.
Chunyu Li et al.
Background: Recently, homozygous variants in PTPA were identified as the disease cause for two pedigrees with early-onset parkinsonism and intellectual disability. Although the initial link between PTPA and parkinsonism h...
Obstructive Sleep Apnea and Striatal Dopamine Availability in Parkinson's Disease [0.03%]
帕金森病的阻塞性睡眠呼吸暂停与纹状体多巴胺能可用性之间的关系
Yoon-Sang Oh,Joong-Seok Kim,Chul Hyoung Lyoo et al.
Yoon-Sang Oh et al.
Background: Sleep disorders are frequently associated with Parkinson's disease. Obstructive sleep apnea syndrome is one of these sleep disorders and is associated with the severity of motor symptoms in Parkinson's disease...
Autosomal Recessive Cerebellar Ataxias in Europe: Frequency, Onset, and Severity in 677 Patients [0.03%]
欧洲全自主性隐性脊小脑共济失调的频率、发病时间和严重程度（677名患者的数据）
Andreas Traschütz,Astrid D Adarmes-Gomez,Mathieu Anheim et al.
Andreas Traschütz et al.
Excessive α-β Oscillations Mark Enlarged Motor Sign Severity and Parkinson's Disease Duration [0.03%]
过高的α-β振荡标志运动症状严重程度和疾病持续时间帕金森病
Elena Belova,Ulia Semenova,Anna Gamaleya et al.
Elena Belova et al.
Background: β Oscillations in the subthalamic nucleus (STN) have been proven to contribute to Parkinson's disease (PD), but the exact borders of β subbands vary substantially across the studies, and information regardin...
Synaptic Loss in Spinocerebellar Ataxia Type 3 Revealed by SV2A Positron Emission Tomography [0.03%]
谷氨酸能突触丢失在脊小脑共济失调3型中的PET影像学研究
Zhao Chen,Guang Liao,Na Wan et al.
Zhao Chen et al.
Background: Severe reduced synaptic density was observed in spinocerebellar ataxia (SCA) in postmortem neuropathology, but in vivo assessment of synaptic loss remains challenging. OBJECTIVE SPINOCEREBELLAR ATAXIA TYPE 3: ...
A TNR Frameshift Variant in Weimaraner Dogs with an Exercise-Induced Paroxysmal Movement Disorder [0.03%]
与运动诱发的阵发性运动障碍相关的德国魏玛犬TNR基因移码突变
Matthias Christen,Rodrigo Gutierrez-Quintana,Matthew James et al.
Matthias Christen et al.
Background: Some paroxysmal movement disorders remain without an identified genetic cause. Objectives: The aim was to identify the caus...
Striatal Dopamine: The Cement of the Brain?: Jeong H, Taylor A, Floeder JR, et al. Mesolimbic dopamine release conveys causal associations. Science 2022;378:eabq6740.: Jeong H, Taylor A, Floeder JR, et al. Mesolimbic dopamine release conveys causal associations. Science 2022;378:eabq6740 [0.03%]
striatal多巴胺：巩固大脑记忆的“胶水”？Jeong H，Taylor A，Floeder JR等. 中脑边缘通路多巴胺释放传递因果联系。Science 2022；378：eabq6740
Roger L Albin,Daniel K Leventhal
Roger L Albin