Low Specificity of Rapid Eye Movement Sleep Behavior Disorder Questionnaires: Need for Better Screening Methods [0.03%]
快速眼动睡眠行为障碍问卷的低特异性：需要更好的筛查方法
Ambra Stefani,Monica Serradell,Evi Holzknecht et al.
Ambra Stefani et al.
Background: Correct diagnosis of rapid eye movement sleep behavior disorder (RBD) is critical due to its link to α-synucleinopathies and risk of injuries and requires video-polysomnography (V-PSG). Usefulness of screenin...
Levodopa Dose Equivalency in Parkinson's Disease: Updated Systematic Review and Proposals [0.03%]
帕金森病左旋多巴当量剂量的系统性综述及建议更新
Stefanie T Jost,Marie-Ann Kaldenbach,Angelo Antonini et al.
Stefanie T Jost et al.
Background: To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark d...
Deep brain stimulation for medically refractory status dystonicus in UBA5-related disorder [0.03%]
UBA5相关性疾病难治性状态性肌张力不全的深部脑刺激治疗
Zainab Zaman,Nadine Straka,Anna L Pinto et al.
Zainab Zaman et al.
Miguel Lopez-Cuina,Paul Guérin,Nathalie Dutheil et al.
Miguel Lopez-Cuina et al.
Background: Multiple system atrophy (MSA) is a sporadic adult-onset rare neurodegenerative synucleinopathy for which counteracting central nervous system insulin resistance bears the potential of being neuroprotective. G-...
The Lessebo Effect in Disease Modification Trials in Parkinson's Disease [0.03%]
帕金森病疾病修正临床试验中的莱斯波效应
Tiago A Mestre,Michael P McDermott,Raquel Lobo et al.
Tiago A Mestre et al.
Background: The impact of expectation of benefit on outcomes is well established in Parkinson's disease (PD). A reduction of a treatment effect due to a perceived placebo allocation (lessebo effect) in randomized controll...
Summing MDS-UPDRS Parts 1 + 2 (Non-motor and Motor Experience of Daily Living): The Patient's Voice [0.03%]
汇总MDS-UPDRS第I部分+ II部分（非运动和运动活动of日常生活经验）：来自患者的叙述
Haotian Zou,Christopher G Goetz,Glenn T Stebbins et al.
Haotian Zou et al.
Axial Postural Abnormalities in Parkinsonism: Gaps in Predictors, Pathophysiology, and Management [0.03%]
帕金森病轴向姿势异常：预测因素、病理生理和治疗的差距
Christian Geroin,Carlo Alberto Artusi,Jorik Nonnekes et al.
Christian Geroin et al.
Scales for Antipsychotic-Associated Movement Disorders: Systematic Review, Critique, and Recommendations [0.03%]
抗精神病药相关运动障碍量表：系统综述、批评和建议
Davide Martino,Vikram Karnik,Roongroj Bhidayasiri et al.
Davide Martino et al.
Background: Antipsychotic-associated movement disorders remain common and disabling. Their screening and assessment are challenging due to clinical heterogeneity and different use of nomenclature between psychiatrists and...
Evaluation of a Structured Screening Assessment to Detect Isolated Rapid Eye Movement Sleep Behavior Disorder [0.03%]
评估一种结构化筛查以检测单一快速眼动睡眠行为障碍的价值
Aline Seger,Anja Ophey,Wiebke Heitzmann et al.
Aline Seger et al.
Background: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) cohorts have provided insights into the earliest neurodegenerative processes in α-synucleinopathies. Even though polysomnography (PSG) remains ...
Ca2+ -Calmodulin-Calcineurin Signaling Modulates α-Synuclein Transmission [0.03%]
钙离子-钙调素-钙神经蛋白信号调节α-突触核蛋白传播
Jun Ueda,Norihito Uemura,Tomoyuki Ishimoto et al.
Jun Ueda et al.
Background: The intercellular transmission of pathogenic proteins plays a crucial role in the progression of neurodegenerative diseases. Previous research has shown that the neuronal uptake of such proteins is activity-de...