A Unified Framework for Evidence-Based Diagnostic Criteria Programs in Movement Disorders [0.03%]
运动障碍基于证据的诊断标准计划的统一框架
Tiago A Mestre,Margherita Fabbri,Sheng Luo et al.
Tiago A Mestre et al.
Impact of APOE Genotype on Cognition in Idiopathic and Genetic Forms of Parkinson's Disease [0.03%]
载脂蛋白E基因型对帕金森病认知功能的影响
Christos Koros,Kathrin Brockmann,Athina-Maria Simitsi et al.
Christos Koros et al.
Application Value of Serum Neurofilament Light Protein for Disease Staging in Huntington's Disease [0.03%]
血清神经丝轻链蛋白在亨廷顿病疾病分期中的应用价值
Xiao-Yan Li,Yu-Feng Bao,Juan-Juan Xie et al.
Xiao-Yan Li et al.
Background: Neurofilament light protein (NfL) has been proven to be a sensitive biomarker for Huntington's disease (HD). However, these studies did not include HD patients at advanced stages or with larger CAG repeats (>5...
Fixel-Based Analysis Reveals Whole-Brain White Matter Abnormalities in Cervical Dystonia [0.03%]
基于固定点的分析揭示了颈椎 dystonia的全脑白质异常
Giuseppe A Zito,Clément Tarrano,Salim Ouarab et al.
Giuseppe A Zito et al.
Background: Cervical dystonia (CD) is a form of isolated focal dystonia typically associated to abnormal head, neck, and shoulder movements and postures. The complexity of the clinical presentation limits the investigatio...
Adaptive Deep Brain Stimulation: From Experimental Evidence Toward Practical Implementation [0.03%]
自适应深部脑刺激：从实验证据到实用实施
Wolf-Julian Neumann,Roee Gilron,Simon Little et al.
Wolf-Julian Neumann et al.
Closed-loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at an unprecedented temporal precision for neurological disorders. This has the potential to lead to a breakthrough in neurotechnology, but the translatio...
CAG Repeat Expansion in THAP11 Is Associated with a Novel Spinocerebellar Ataxia [0.03%]
THAP11基因的CAG重复序列扩增与新型脊髓小脑共济失调相关性研究
Dandan Tan,Cuijie Wei,Zhao Chen et al.
Dandan Tan et al.
Background: More than 50 loci are associated with spinocerebellar ataxia (SCA), and the most frequent subtypes share nucleotide repeats expansion, especially CAG expansion. ...
Potential Protective Link Between Type I Diabetes and Parkinson's Disease Risk and Progression [0.03%]
I型糖尿病与帕金森病风险和进展之间的潜在保护性联系
Konstantin Senkevich,Paria Alipour,Ekaterina Chernyavskaya et al.
Konstantin Senkevich et al.
Background: Epidemiological studies suggested an association between Parkinson's disease (PD) and type 2 diabetes, but less is known about type 1 diabetes (T1D) and PD. ...
Validation of the Rainbow Model of Integrated Care Measurement Tool in Parkinson's Disease [0.03%]
帕金森病综合护理评估彩虹模型测量工具的验证研究
Pim P Valentijn,Carsten Eggers,Bastiaan R Bloem et al.
Pim P Valentijn et al.
Background: Integrated care is essential for improving the management and health outcomes for people with Parkinson's disease (PD); reliable and objective measures of care integration are few. ...
Jamie L Hamilton,James A Mills,Glenn T Stebbins et al.
Jamie L Hamilton et al.
Background: Minimal clinically important difference (MCID) represents the smallest within-person change on an outcome measure considered meaningful to the patient. Anchor-based MCID methods evaluate the relationship betwe...
Gene Therapy for Dopamine Dyshomeostasis: From Parkinson's to Primary Neurotransmitter Diseases [0.03%]
多巴胺稳态基因治疗：从帕金森病到原发性神经递质疾病
Joanne Ng,Serena Barral,Simon N Waddington et al.
Joanne Ng et al.
Neurological disorders encompass a broad range of neurodegenerative and neurodevelopmental diseases that are complex and almost universally without disease modifying treatments. There is, therefore, significant unmet clinical need to develo...