Jacques Duysens,Bouwien Smits-Engelsman
Jacques Duysens
Parkin Maintains Robust Pacemaking in Human Induced Pluripotent Stem Cell-Derived A9 Dopaminergic Neurons [0.03%]
帕金蛋白维持人多能干细胞来源黑质神经元的起搏功能
Jiali Pu,Lin Lin,Houbo Jiang et al.
Jiali Pu et al.
Background: The degeneration of nigral (A9) dopaminergic (DA) neurons results in cardinal motor symptoms that define Parkinson's disease (PD). Loss-of-function mutations in parkin are linked to a rare form of early-onset ...
Procedure-Related Complications in Sham Surgeries for Parkinson's Clinical Trials: A Meta-analysis [0.03%]
帕金森病临床试验中假手术的相关并发症：一项系统综述和meta分析
James C Mamaril-Davis,Adrian W Gelb,Paul S Larson
James C Mamaril-Davis
Background: Double-blind, sham-controlled neurosurgical trials for neurodegenerative disorders are debated as an ethical dilemma, particularly regarding subjects randomized to the sham surgery group with general anesthesi...
Detection of the ACAGG Repeat Motif in RFC1 in Two Dutch Ataxia Families [0.03%]
两个荷兰共济病家系中RFC1基因ACAGG重复序列的检测
Milo van de Pol,Luke O&#x;Gorman,Jordi Corominas-Galbany et al.
Milo van de Pol et al.
Olfactory Neuron Substance P is Overexpressed in Parkinson's Disease Reflecting Gut Dysfunction [0.03%]
帕金森病中嗅觉神经物质P过度表达反映了肠道功能障碍
Tommaso Schirinzi,Daniela Maftei,Piergiorgio Grillo et al.
Tommaso Schirinzi et al.
Guy C Brown,Marta Camacho,Caroline H Williams-Gray
Guy C Brown
The endotoxin hypothesis of Parkinson's disease (PD) is the idea that lipopolysaccharide (LPS) endotoxins contribute to the pathogenesis of this disorder. LPS endotoxins are found in, and released from, the outer membrane of Gram-negative b...
Céline Bonnet
Céline Bonnet
Differences Among Native Hawaiian, Asian, and White Patients with Progressive Supranuclear Palsy [0.03%]
皮克病患者的临床特征及遗传学分析：一项多中心研究
Ashok Kannan,Kyle Ishikawa,John Chen et al.
Ashok Kannan et al.
Background: Most studies of progressive supranuclear palsy (PSP) have been conducted in White populations. Objective: The objective of ...
Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease [0.03%]
帕金森病患者的脑血管反应性降低及延迟
Sephira G Ryman,Nicholas Shaff,Andrew Dodd et al.
Sephira G Ryman et al.
Background: Cerebrovascular dysfunction in Parkinson's disease (PD) is heterogeneous and may contribute to disease pathophysiology or progression. There is a need to understand the mechanisms by which cerebrovascular dysf...
Defining the Riddle in Order to Solve It: There Is More Than One "Parkinson's Disease" [0.03%]
化解谜题以求解答：帕金森病不止一种
Tiago F Outeiro,Roy N Alcalay,Angelo Antonini et al.
Tiago F Outeiro et al.
Background: More than 200 years after James Parkinsondescribed a clinical syndrome based on his astute observations, Parkinson's disease (PD) has evolved into a complex entity, akin to the heterogeneity of other complex h...