Philip Harrer,Nazanin Mirza-Schreiber,Vanessa Mandel et al.
Philip Harrer et al.
Background: As opposed to other neurobehavioral disorders, epigenetic analyses and biomarkers are largely missing in the case of idiopathic restless legs syndrome (RLS). ...
Cognitive Safety Data from a Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Phase IIb Study of the Effects of a Cannabidiol and Δ9-Tetrahydrocannabinol Drug on Parkinson's Disease-Related Motor Symptoms [0.03%]
一项大麻二酚和Δ9-四氢大麻酚药物对帕金森病相关运动症状影响的随机、双盲、平行组、安慰剂对照IIb期临床试验的认知安全性数据
Christopher H Domen,Stefan Sillau,Ying Liu et al.
Christopher H Domen et al.
Background: Cannabis is increasingly available worldwide but its impact on cognition in Parkinson's disease (PD) is unknown. Objective: ...
Musician's Dystonia: Family History as a Predictor for Onset and Course of the Disease [0.03%]
音乐家的异动症：家族史作为发病及病程预测指标的重要性
Johanna Doll-Lee,André Lee,Shinichi Furuya et al.
Johanna Doll-Lee et al.
Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial [0.03%]
帕金森病的纹状体输注脑多巴胺神经生长因子：一项随机、双盲、多中心Ⅰ期临床试验
Henri J Huttunen,Sigrid Booms,Magnus Sjögren et al.
Henri J Huttunen et al.
Background: Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that protects dopamine neurons and improves motor function in animal models of Parkinson's disease (PD). ...
Development and Validation of the Dystonia-Pain Classification System: A Multicenter Study [0.03%]
扭转痉挛疼痛分类系统的建立与多中心研究
Clarice Listik,Eduardo Listik,Flávia de Paiva Santos Rolim et al.
Clarice Listik et al.
Background: Dystonia is associated with disabling nonmotor symptoms like chronic pain (CP), which is prevalent in dystonia and significantly impacts the quality of life (QoL). There is no validated tool for assessing CP i...
Marius Krösche,Silja Kannenberg,Markus Butz et al.
Marius Krösche et al.
Background: Diagnosis of atypical parkinsonian syndromes (APS) mostly relies on clinical presentation as well as structural and molecular brain imaging. Whether parkinsonian syndromes are distinguishable based on neuronal...
A Phase 1B Trial in GBA1-Associated Parkinson's Disease of BIA-28-6156, a Glucocerebrosidase Activator [0.03%]
GBA1相关帕金森病的 glucocerebrosidase 激活剂 BIA-28-6156 Ⅰb 期临床试验
Jonas M den Heijer,Annelieke C Kruithof,Matthijs Moerland et al.
Jonas M den Heijer et al.
Background: Loss-of-function mutations in the GBA1 gene are one of the most common genetic risk factors for onset of Parkinson's disease and subsequent progression (GBA-PD). GBA1 encodes the lysosomal enzyme glucocerebros...
Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [11 C]UCB-J Positron Emission Tomography Study [0.03%]
原发性tau病的纵向突触丢失：一项体内[11C]UCB-J正电子发射断层扫描研究
Negin Holland,P Simon Jones,George Savulich et al.
Negin Holland et al.
Background: Synaptic loss is characteristic of many neurodegenerative diseases; it occurs early and is strongly related to functional deficits. Objective:...
Shameer Rafee,Conor Fearon
Shameer Rafee
Nele Sophie Brügge,Gesine Marie Sallandt,Ronja Schappert et al.
Nele Sophie Brügge et al.
Background: Video-based tic detection and scoring is useful to independently and objectively assess tic frequency and severity in patients with Tourette syndrome. In trained raters, interrater reliability is good. However...