Integrative Brain States Facilitate the Expression of Parkinson's Tremor [0.03%]
整合的大脑状态有助于帕金森病震颤的表达
Michiel F Dirkx,James M Shine,Rick C Helmich
Michiel F Dirkx
Background: Parkinson's disease (PD) rest tremor emerges from pathological activity in the basal ganglia and cerebello-thalamo-cortical circuits. A well-known clinical feature is the waxing and waning of PD tremor amplitu...
Predicting Ambulatory Capacity in Parkinson's Disease to Analyze Progression, Biomarkers, and Trial Design [0.03%]
预测帕金森病步行能力以分析病情进展、生物标志物和试验设计
Charles S Venuto,Greta Smith,Konnor Herbst et al.
Charles S Venuto et al.
Background: In Parkinson's disease (PD), gait and balance is impaired, relatively resistant to available treatment and associated with falls and disability. Predictive models of ambulatory progression could enhance unders...
Long-Term Follow-Up of Pediatric Patients with Dyskinetic Cerebral Palsy and Deep Brain Stimulation [0.03%]
儿外科患者脑瘫伴运动障碍的长期随访研究及深部脑刺激治疗效果
Anne Koy,Andrea A Kühn,Petra Schiller et al.
Anne Koy et al.
Background: Deep brain stimulation (DBS) has been increasingly used in the management of dyskinetic cerebral palsy (DCP). Data on long-term effects and the safety profile are rare. ...
Nigral Pathology Contributes to Microstructural Integrity of Striatal and Frontal Tracts in Parkinson's Disease [0.03%]
黑质病理改变与帕金森病纹状体和额叶纤维束微结构完整性关系的探究
Chen-Pei Lin,Lydian E J Knoop,Irene Frigerio et al.
Chen-Pei Lin et al.
Background: Motor and cognitive impairment in Parkinson's disease (PD) is associated with dopaminergic dysfunction that stems from substantia nigra (SN) degeneration and concomitant α-synuclein accumulation. Diffusion ma...
Increased Free Water in the Putamen in Idiopathic REM Sleep Behavior Disorder [0.03%]
特发性REM睡眠行为障碍中壳核自由水增加现象
Dongling Zhang,Liche Zhou,Junye Yao et al.
Dongling Zhang et al.
Background: It has been suggested that the loss of nigrostriatal dopaminergic axon terminals occurs before the loss of dopaminergic neurons in the substantia nigra (SN) in Parkinson's disease (PD). This study aimed to use...
Memory Phenotypes In Early, De Novo Parkinson's Disease Patients with Mild Cognitive Impairment [0.03%]
早期新发帕金森病轻度认知障碍患者的记忆表型特征研究
Mattia Siciliano,Rosa De Micco,Andrea Gerardo Russo et al.
Mattia Siciliano et al.
Background: Memory deficits in mild cognitive impairment related to Parkinson's disease (PD-MCI) are quite heterogeneous, and there is no general agreement on their genesis. ...
Adjusting for Underrepresentation Reveals Widespread Underestimation of Parkinson's Disease Symptom Burden [0.03%]
校正不足估计发现帕金森症症状负担广泛被低估
Ali G Hamedani,Peggy Auinger,Allison W Willis et al.
Ali G Hamedani et al.
Background: Clinical research is limited by underrepresentation, but the impact of underrepresentation on patient-reported outcomes in Parkinson's disease (PD) is unknown. ...
Confirmation of the Pathogenetic Role of the CCDC88C Gene in Early-Onset Pure Spastic Paraplegia [0.03%]
CCDC88C基因在早期发病的单纯性痉挛性截瘫中的致病作用的确证研究
Donatella Caputo,Valentina Cetica,Silvia Paoli et al.
Donatella Caputo et al.
The Emergence and Progression of Motor Dysfunction in Individuals at Risk of Parkinson's Disease [0.03%]
帕金森病高风险个体的运动功能障碍的发生和进展
Cristina Simonet,Philipp Mahlknecht,Kathrin Marini et al.
Cristina Simonet et al.
Background: PREDICT-PD is a United Kingdom population-based study aiming to stratify individuals for future Parkinson's disease (PD) using a risk algorithm. ...
Anne Weissbach,Josephine Moyé,Adam Takacs et al.
Anne Weissbach et al.
Background: Although functional neurological movement disorders (FMD) are characterized by motor symptoms, sensory processing has also been shown to be disturbed. However, how the integration of perception and motor proce...