The Self-Administered Screening Questionnaire for Parkinson's Disease-Associated Psychosis (SASPAP) [0.03%]
帕金森病相关精神病自评筛查问卷（SASPAP）
Vindhya Koneru,Alberto J Espay,Allan J Cole et al.
Vindhya Koneru et al.
Background: Psychosis is a common manifestation of Parkinson's disease (PD), and a major source of caregiver burden, nursing home placement, and mortality. Psychosis symptoms are often not volunteered during the clinic vi...
Progressive Brain Atrophy in Multiple System Atrophy: A Longitudinal, Multicenter, Magnetic Resonance Imaging Study [0.03%]
多系统萎缩的进行性脑萎缩：一项纵向多中心磁共振成像研究
Florian Krismer,Patrice Péran,Vincent Beliveau et al.
Florian Krismer et al.
Objective: To determine the rates of brain atrophy progression in vivo in patients with multiple system atrophy (MSA). Background: Surr...
Free-Water Imaging in Friedreich Ataxia Using Multi-Compartment Models [0.03%]
弗里德赖希共济失调的自由水 imaging 多室模型分析
Lara Fernandez,Louise A Corben,Hiba Bilal et al.
Lara Fernandez et al.
Background: The neurological phenotype of Friedreich ataxia (FRDA) is characterized by neurodegeneration and neuroinflammation in the cerebellum and brainstem. Novel neuroimaging approaches quantifying brain free-water us...
Long-Read Sequencing Resolves a Complex Structural Variant in PRKN Parkinson's Disease [0.03%]
长读测序解析出Parkinson病相关PRKN基因复杂结构变异
Kensuke Daida,Manabu Funayama,Kimberley J Billingsley et al.
Kensuke Daida et al.
Background: Parkin RBR E3 ubiquitin-protein ligase (PRKN) mutations are the most common cause of young onset and autosomal recessive Parkinson's disease (PD). PRKN is located in FRA6E, which is one of the common fragile s...
Frequency of Hereditary and GBA1-Related Parkinsonism in Latin America: A Systematic Review and Meta-Analysis [0.03%]
拉丁美洲遗传性和GBA1相关帕金森病患病率的系统评价和meta分析
Paula Saffie Awad,Daniel Teixeira-Dos-Santos,Bruno Lopes Santos-Lobato et al.
Paula Saffie Awad et al.
Background: Identifying hereditary parkinsonism is valuable for diagnosis, genetic counseling, patient prioritization in trials, and studying the disease for personalized therapies. However, most studies were conducted in...
Cognitive Effects of Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease with GBA1 Pathogenic Variants [0.03%]
GBA1致病突变帕金森病患者 subthalamic nucleus深部脑刺激的认知效应
Gian D Pal,Daniel M Corcos,Leo Verhagen Metman et al.
Gian D Pal et al.
Genetic subtyping of patients with Parkinson's disease (PD) may assist in predicting the cognitive and motor outcomes of subthalamic deep brain stimulation (STN-DBS). Practical questions were recently raised with the emergence of new data r...
Unraveling the Twist: Spatial Navigational Challenges in Cervical Dystonia [0.03%]
解开谜团：痉挛性 cervical dystonia 的空间导航挑战
Hanieh Agharazi,Alexander Wang,Aratrik Guha et al.
Hanieh Agharazi et al.
Background: Cervical dystonia (CD) is an intricate neurological condition with motor and nonmotor symptoms. These include disruptions in visual perception, self-orientation, visual working memory, and vestibular functions...
Long-Term Nicotinamide Riboside Use Improves Coordination and Eye Movements in Ataxia Telangiectasia [0.03%]
长期使用烟酰胺核糖可改善小眼球症患者的协调性和眼动功能
Rebecca Presterud,Wei Hai Deng,Anna Berit Wennerström et al.
Rebecca Presterud et al.
Background: Supplementation of nicotinamide riboside (NR) ameliorates neuropathology in animal models of ataxia telangiectasia (A-T). In humans, short-term NR supplementation showed benefits in neurological outcome. ...
Paradoxical Modulation of STN β-Band Activity with Medication Compared to Deep Brain Stimulation [0.03%]
与深部脑刺激相比，多巴胺能药物通过矛盾的方式调节STN的β频段活动
Meghan E Hill,Luke A Johnson,Jing Wang et al.
Meghan E Hill et al.
Background: Excessive subthalamic nucleus (STN) β-band (13-35 Hz) synchronized oscillations has garnered interest as a biomarker for characterizing disease state and developing adaptive stimulation systems for Parkinson'...
A Randomized Phase 3 Study Comparing P2B001 to its Components (Low-Dose Extended-Release Rasagiline and Pramipexole) and to Optimized Doses of Marketed Extended-Release Pramipexole in Early Parkinson's Disease [0.03%]
帕金森病早期患者P2B001与等剂量的恩他卡朋/左旋多巴、雷沙吉兰和普拉克索联合治疗相比的随机双盲3期研究
C Warren Olanow,Robert A Hauser,Daniel J Burdick et al.
C Warren Olanow et al.
Background: There remains uncertainty as to the optimal way to initiate therapy for Parkinson's disease (PD) to maximize benefit and minimize adversity. O...