Dysregulation of Monounsaturated Fatty Acids is Related to α-Synuclein in Multiple System Atrophy [0.03%]
单不饱和脂肪酸的失调与多系统萎缩中的α-突触核蛋白相关
Finula I Isik,YuHong Fu,Russell Pickford et al.
Finula I Isik et al.
Background: Multiple system atrophy (MSA) is a neurodegenerative disease pathologically characterized by the presence of glial cytoplasmic inclusions (GCI) composed of α-synuclein aggregates. In Parkinson's disease, incr...
Measuring What Matters in Parkinson's Disease Research and Dysphagia: The Need for Core Outcome Sets [0.03%]
测量帕金森病研究和吞咽困难中重要的指标：需要核心成果集的时刻到了
Margaret Walshe,Julia Hirschwald,Tobias Warnecke
Margaret Walshe
EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder [0.03%]
韦玛犬中与先天性镜像运动障碍相似的条件下的EFNB3移码变异
Cleo Schwarz,Florian Bartenschlager,Olivia Kershaw et al.
Cleo Schwarz et al.
Background: Congenital mirror movement disorders (CMMs) are clinically and genetically heterogeneous in human patients. CMMs have not been documented to occur spontaneously in animals. ...
Capture of Longitudinal Change in Real-Life Walking in Cerebellar Ataxia Increases Patient Relevance and Effect Size [0.03%]
纵向捕获小脑共济失调患者真实步行变化可提高研究的临床意义和统计功效
Jens Seemann,Theresa Beyme,Natalie John et al.
Jens Seemann et al.
Background: With disease-modifying drugs for degenerative ataxias on the horizon, ecologically valid measures of gait performance that can detect patient-relevant changes in trial-like time frames are highly warranted. ...
Intraputaminal Delivery of Adeno-Associated Virus Serotype 2-Glial Cell Line-Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease [0.03%]
轻至中度帕金森病患者黑质输注AAV2-GDNF的效果和安全性研究：一项多中心、双盲、随机、安慰剂平行分组的II期临床试验
Amber D Van Laar,Chadwick W Christine,Nicolás Phielipp et al.
Amber D Van Laar et al.
Background: Glial cell line-derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower-dose adeno-associated virus serotype 2-GDNF (AAV2-GDNF) bi...
Peripheral Mononuclear Cell Mitochondrial Function Associates with T-Cell Cytokines in Parkinson's Disease [0.03%]
帕金森病外周单核细胞线粒体功能与T细胞细胞因子相关性研究
Fatima Afaar,Priscilla Youssef,Jasmin Galper et al.
Fatima Afaar et al.
Background: Parkinson's disease (PD) is the most common neurodegenerative movement disorder and one of the world's fastest-growing neurological diseases. Although the exact causes of PD are unknown, mitochondrial dysfunct...
Rapid Eye Movements (REMs) during Non-REM Sleep as a Marker of Alpha-Synucleinopathies [0.03%]
非快速眼动睡眠期间的眼快运动作为α-突触核蛋白病的标志
Estefania Vargas Gonzalez,Zhongmei Yang,Pauline Dodet et al.
Estefania Vargas Gonzalez et al.
Background: Alpha-synuclein-related neurodegeneration affects sleep figures, whether in the prodromal (rapid eye movement [REM] sleep behavior disorder, iRBD) or established (Parkinson's disease [PD] and multiple system a...
Abnormal Brain Iron Metabolism is Linked to Altered Neural Function in Isolated Laryngeal Dystonia [0.03%]
异常的脑铁代谢与孤立性喉肌张力障碍的神经功能改变有关
Giovanni Battistella,Laura de Lima Xavier,Alexander O Vortmeyer et al.
Giovanni Battistella et al.
Background: Laryngeal dystonia (LD) is an isolated focal dystonia causing involuntary spasms in the laryngeal muscles that selectively impair speech production. LD is characterized as a functional and structural neural ne...
Development and Preliminary Validation of a Parkinsonism-Dystonia Scale for Infants and Young Children [0.03%]
婴儿和学龄前儿童帕金森综合征-肌张力障碍量表的制定及初步验证研究
Roser Pons,Toni S Pearson,Belen Perez-Dueñas et al.
Roser Pons et al.
Background: Parkinsonism in infancy is rare and is highly correlated with the presence of dystonia. Advances in treating and characterizing developmental and infantile degenerative parkinsonism have highlighted the need f...