Digital Gait Outcomes for Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS): Discriminative, Convergent, and Ecological Validity in a Multicenter Study (PROSPAX) [0.03%]
查尔勒沃伊斯-萨格奈自毁容貌症（ARSACS）的数字步态结局：多中心研究（PROSPAX）中的区分效度、汇聚效度和生态效度评估
Lukas Beichert,Winfried Ilg,Christoph Kessler et al.
Lukas Beichert et al.
Background: With treatment trials on the horizon, this study aimed to identify candidate digital-motor gait outcomes for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), capturable by wearable sensors w...
Impact of Magnetic Resonance Imaging Markers on the Diagnostic Performance of the International Parkinson and Movement Disorder Society Multiple System Atrophy Criteria [0.03%]
磁共振成像标志物对国际帕金森病和运动障碍学会多系统萎缩诊断标准性能的影响
Ida Jensen,Johanne Heine,Viktoria C Ruf et al.
Ida Jensen et al.
Background: Multiple system atrophy is a neurodegenerative disease with α-synuclein aggregation in glial cytoplasmic inclusions, leading to dysautonomia, parkinsonism, and cerebellar ataxia. ...
MRI-ARSACS: An Imaging Index for Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) Identification Based on the Multicenter PROSPAX Study [0.03%]
基于多中心PROSPAX研究的夏勒维克斯-萨格奈自体显性痉挛性共济失调(MRI-ARSACS)的影像学指标
Alessandra Scaravilli,Davide Negroni,Claudio Senatore et al.
Alessandra Scaravilli et al.
Background: Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and hereditary spastic paraplegia type 7 (SPG7) represent the most common genotypes of spastic ataxia (SPAX). To date, their magnetic resonanc...
Magnetic Resonance Imaging Measures to Track Atrophy Progression in Progressive Supranuclear Palsy in Clinical Trials [0.03%]
用于临床试验中追踪进行性核上性麻痹萎缩进展的磁共振成像措施
Andrea Quattrone,Nicolai Franzmeier,Hans-Jürgen Huppertz et al.
Andrea Quattrone et al.
Background: Several magnetic resonance imaging (MRI) measures have been suggested as progression biomarkers in progressive supranuclear palsy (PSP), and some PSP staging systems have been recently proposed. ...
Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases [0.03%]
路易体疾病中的异常脑血管活性、灌注和glymphatic清除
Sephira G Ryman,Andrei A Vakhtin,Andrew R Mayer et al.
Sephira G Ryman et al.
Cerebrovascular activity is not only crucial to optimal cerebral perfusion, but also plays an important role in the glymphatic clearance of interstitial waste, including α-synuclein. This highlights a need to evaluate how cerebrovascular a...
Chengqian Zhou,Fan Tang,Tao Dong et al.
Chengqian Zhou et al.
Background: Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disease caused by a CAG/CTG repeat expansion at the PPP2R2B locus. Objective: ...
Increased CSF DOPA Decarboxylase Correlates with Lower DaT-SPECT Binding: Analyses in Biopark and PPMI Cohorts [0.03%]
生物公园和PPMI队列中CSF多巴胺脱羧酶升高与DAT-SPECT结合降低相关性分析
Shervin Khosousi,Andrea Sturchio,Ellen Appleton et al.
Shervin Khosousi et al.
Background: Recent studies identified increased cerebrospinal fluid (CSF) DOPA decarboxylase (DDC) as a promising biomarker for parkinsonian disorders, suggesting a compensation to dying dopaminergic neurons. A correlatio...
Plasticity-Induced Effects of Theta Burst Transcranial Ultrasound Stimulation in Parkinson's Disease [0.03%]
经颅超声 theta 爆震刺激在帕金森病中的诱导可塑性效应
Talyta Grippe,Yazan Shamli-Oghli,Ghazaleh Darmani et al.
Talyta Grippe et al.
Background: Low-intensity transcranial ultrasound stimulation (TUS) is a noninvasive brain stimulation (NIBS) technique with high spatial specificity. Previous studies showed that TUS delivered in a theta burst pattern (t...
A New Star in the Sky of Tic Pathophysiology: The Role of Astrocytes in Repetitive Motor Behaviors [0.03%]
肌张力障碍病理学天空中的一颗新星： astrocyte 在重复运动行为中的作用
Christos Ganos,Anthony E Lang,Izhar Bar-Gad
Christos Ganos
Dysregulated Cerebrospinal Fluid Proteome of Spinocerebellar Ataxia Type 2 and its Clinical Implications [0.03%]
脊髓小脑共济失调2型脑脊液蛋白组异常及其临床意义
Albert Stezin,Gajanan J Sathe,Akshada Gajbhiye et al.
Albert Stezin et al.
Background: Abnormalities in ataxin-2 associated with spinocerebellar ataxia type 2 (SCA2) may lead to widespread disruptions in the proteome. This study was performed to identify dysregulated proteome in SCA2 and to expl...