Proteomic Profiling in Dystonia: The Next Frontier for Pathophysiology Research and Biomarker Exploration [0.03%]
扭转痉挛的蛋白质组学 profiling:病理生理研究和生物标志物探索的新前沿
Holger Prokisch,Michael Zech
Holger Prokisch
Computerized Cognitive Training Increases Gray Matter Volumes in Huntington's Disease: A Pilot Study [0.03%]
计算机认知训练可增加亨廷顿病患者的灰质体积：一项初步研究
Katharine Huynh,Nellie Georgiou-Karistianis,Amit Lampit et al.
Katharine Huynh et al.
Probabilistic Refinement of Focused Ultrasound Thalamotomy Targeting for Parkinson's Disease Tremor [0.03%]
帕金森病震颤的聚焦超声丘脑损毁治疗的目标优化的概率研究
Cletus Cheyuo,Jürgen Germann,Kazuaki Yamamoto et al.
Cletus Cheyuo et al.
Background: There remains high variability in clinical outcomes when the same magnetic resonance image-guided focused ultrasound (MRgFUS) thalamotomy target is used for both essential tremor (ET) and tremor-dominant Parki...
Severe Acute Motor Exacerbations (SAME) across Metabolic, Developmental and Genetic Disorders [0.03%]
代谢、发育和遗传障碍中的严重急性运动恶化(SAME)
Blas Couto,Serena Galosi,Dora Steel et al.
Blas Couto et al.
Acute presentation of severe motor disorders is a diagnostic and management challenge. We define severe acute motor exacerbations (SAME) as acute/subacute motor symptoms that persist for hours-to-days with a severity that compromise vital s...
Functional Movement Disorder as a Prodromal Symptom of Parkinson's Disease-Clinical and Pathophysiological Insights [0.03%]
帕金森病的前驱症状的功能性运动障碍——临床和病理生理学见解
Elie Matar,Michele Tinazzi,Mark J Edwards et al.
Elie Matar et al.
Functional movement disorder (FMD) is a common manifestation of functional neurological disorder. FMD can occur alongside other neurological conditions, but especially in patients with established Parkinson's disease (PD). An interesting ob...
Frequency-Selective Suppression of Essential Tremor via Transcutaneous Spinal Cord Stimulation [0.03%]
基于经皮脊髓刺激的选择性频率抑制特发性震颤研究
Alejandro Pascual-Valdunciel,Jaime Ibáñez,Lorenzo Rocchi et al.
Alejandro Pascual-Valdunciel et al.
Background: Essential tremor (ET) is a common debilitating condition, yet current treatments often fail to provide satisfactory relief. Transcutaneous spinal cord electrical stimulation (tSCS) has emerged as a potential n...
Nicole Campese,Georg Göbel,Julia Wanschitz et al.
Nicole Campese et al.
Background: Pain is a frequent yet poorly characterized symptom of multiple system atrophy (MSA). Understanding the factors influencing pain and its burden is crucial for improving the symptomatic treatment and quality of...
Time to Functional Loss as an Endpoint in Huntington's Disease Trials: Enrichment and Sample Size [0.03%]
亨廷顿舞蹈病临床试验中以功能丧失至某一时点作为终点的丰富度和样本量分析
James A Mills,Jeffrey D Long,Jatin G Vaidya et al.
James A Mills et al.
Background: Clinical trial scenarios can be modeled using data from observational studies, providing critical information for design of real-world trials. The Huntington's Disease Integrated Staging System (HD-ISS) charac...
Distinct Clinical Implications of Patient- Versus Clinician-Rated Motor Symptoms in Parkinson's Disease [0.03%]
帕金森病患者和医生评估的运动症状不同的临床意义
Akihiro Kikuya,Kazuto Tsukita,Masanori Sawamura et al.
Akihiro Kikuya et al.
Background: Patient-rated motor symptoms (PRMS) and clinician-rated motor symptoms (CRMS) often differ in Parkinson's disease (PD). Objective: ...
Small Particles, Big Potential: Polymeric Nanoparticles for Drug Delivery in Parkinson's Disease [0.03%]
帕金森病的药物递送：聚合物纳米颗粒的潜在应用
Sasivimol Virameteekul,Andrew J Lees,Roongroj Bhidayasiri
Sasivimol Virameteekul
Despite the availability of a number of efficacious treatments for Parkinson's disease, their limitations and drawbacks, particularly related to low brain bioavailability and associated side effects, emphasize the need for alternative and m...