The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from ENIGMA-Ataxia [0.03%]
ENIGMA小脑萎缩亚型2的萎缩模式及分期：体积定量分析
Jason W Robertson,Isaac Adanyeguh,Benjamin Bender et al.
Jason W Robertson et al.
Background: Spinocerebellar ataxia type 2 (SCA2) is a rare, inherited neurodegenerative disease characterized by progressive deterioration in both motor coordination and cognitive function. Atrophy of the cerebellum, brai...
Elena Cecilia Rosca,Divyani Garg,Santiago Perez-Lloret et al.
Elena Cecilia Rosca et al.
Movement disorders after dengue virus (DENV) infection have been increasingly recognized. We aimed to synthesize the clinical and paraclinical characteristics, treatment responses, and outcomes of these neurologic complications. We systemat...
Effects of Montelukast on Neuroinflammation in Parkinson's Disease: An Open Label Safety and Tolerability Trial with CSF Markers and [11C]PBR28 PET [0.03%]
蒙特鲁卡斯特对帕金森病神经炎症的影响：一项开放标签的安全性和耐受性试验，具有脑脊液生物标志物和[11C]PBR28正电子发射断层扫描(PET)
Johan Wallin,Anton Forsberg,Per Svenningsson
Johan Wallin
Background: Dysregulated leukotriene signaling is proposed to be involved in pathogenesis of Parkinson's disease (PD). Objective: The o...
New Insights into the Association of Pesticide Exposure and Parkinson's Disease [0.03%]
农药暴露与帕金森病关联性的新见解
Bruno Lopes Santos-Lobato
Bruno Lopes Santos-Lobato
Motor Symptom Variability in Parkinson's Disease: Implications for Personalized Trial Outcomes? [0.03%]
帕金森病的运动症状变异及其对个性化临床试验结果的影响？
Jules Janssen Daalen,Maudy van der Heiden,Marjan Meinders et al.
Jules Janssen Daalen et al.
Background: The Movement Disorders Society Unified Parkinson Disease Rating Scale (MDS-UPDRS), Part III, is the gold standard for assessing motor symptoms in Parkinson's disease (PD). However, motor symptoms fluctuate sig...
Addressing Methodological Variability and Enhancing Efficacy Assessment in Focused Ultrasound Thalamotomy for Parkinson's Tremor [0.03%]
提高帕金森病丘脑震颤聚焦超声丘脑毁损术疗效评估及降低操作变异性的方法学研究
Yinfang Wu,Weixing Xu
Yinfang Wu
Samuel Gibbon,David P Breen,Thomas J MacGillivray;UK Biobank Eye & Vision Consortium
Samuel Gibbon
Background: Recent studies have suggested that retinal changes measured with optical coherence tomography are detectable in early Parkinson's disease (PD), highlighting the potential of ophthalmic biomarkers for diagnosis...
Evidence of Involvement of the Calcitonin Gene-Related Peptide in Restless Legs Syndrome [0.03%]
降钙素基因相关肽与不安腿综合征关系的证据
Maria P Mogavero,Mojibola Fowowe,Akeem Sanni et al.
Maria P Mogavero et al.
Background: Restless legs syndrome (RLS) is a common sensory-motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplement...
Altered Intra- and Inter-Network Resting-State Functional Connectivity is Associated with Neuropsychological Functioning and Clinical Symptoms in Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder [0.03%]
孤立性快速眼动睡眠行为障碍患者的神经心理功能和临床症状与静息态功能连接改变有关
Ignacio Roura,Jèssica Pardo,Cristina Martín-Barceló et al.
Ignacio Roura et al.
Background: Isolated rapid-eye movement (REM) sleep behavior disorder (iRBD) is characterized by abnormal behaviors in REM sleep and is considered as a prodromal symptom of alpha-synucleinopathies. Resting-state functiona...
Brain Age as a New Measure of Disease Stratification in Huntington's Disease [0.03%]
脑年龄作为亨廷顿舞蹈病患者疾病分层的新指标
Pubu M Abeyasinghe,James H Cole,Adeel Razi et al.
Pubu M Abeyasinghe et al.
Background: Despite advancements in understanding Huntington's disease (HD) over the past two decades, absence of disease-modifying treatments remains a challenge. Accurately characterizing progression states is crucial f...