Plasma Biomarkers and Positron Emission Tomography Tau Pathology in Progressive Supranuclear Palsy [0.03%]
进行性核上性麻痹血浆生物标志物和正电子发射断层扫描tau病理学研究
Shu-Yi Huang,Shu-Fen Chen,Mei Cui et al.
Shu-Yi Huang et al.
Background: Development of disease-modifying therapeutic trials of progressive supranuclear palsy (PSP) urges the need for sensitive fluid biomarkers. Obj...
Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort [0.03%]
通过DeNoPa队列对孤立的快速眼动睡眠行为障碍和新发帕金森病患者的脑脊液α-突触核蛋白种子进行准确检测
Luis Concha-Marambio,Sandrina Weber,Carly M Farris et al.
Luis Concha-Marambio et al.
Background: Misfolded α-synuclein (αSyn) aggregates (αSyn-seeds) in cerebrospinal fluid (CSF) are biomarkers for synucleinopathies such as Parkinson's disease (PD). αSyn-seeds have been detected in prodromal cases wit...
18 F-Florzolotau Positron Emission Tomography Imaging of Tau Pathology in the Living Brains of Patients with Corticobasal Syndrome [0.03%]
18F-氟化florzolotau正电子发射断层显像在皮质基底综合征患者活脑中的tau病理成像
Feng-Tao Liu,Jia-Ying Lu,Xin-Yi Li et al.
Feng-Tao Liu et al.
Background: Recent development in tau-sensitive tracers has sparkled significant interest in tracking tauopathies using positron emission tomography (PET) biomarkers. However, the ability of 18 F-florzolotau PET imaging t...
Dermal Real-Time Quaking-Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α-Synucleinopathy [0.03%]
皮肤实时震颤诱导转化可作为确认孤立性快速眼动睡眠行为障碍的敏感标志以早期诊断α-突触核蛋白病
Anastasia Kuzkina,Celine Panzer,Aline Seger et al.
Anastasia Kuzkina et al.
Background: Skin biopsy is a potential tool for the premortem confirmation of an α-synucleinopathy. Objective: The aim was to assess t...
A Screening Tool to Quickly Identify Movement Disorders in Patients with Inborn Errors of Metabolism [0.03%]
代谢紊乱患者运动障碍的快速筛查工具
Lisette H Koens,Marrit R Klamer,Deborah A Sival et al.
Lisette H Koens et al.
Background: Movement disorders are frequent in patients with inborn errors of metabolism (IEMs) but poorly recognized, particularly by nonmovement disorder specialists. We propose an easy-to-use clinical screening tool to...
The Pathogenesis of Paroxysmal Kinesigenic Dyskinesia: Current Concepts [0.03%]
阵发性运动诱发 dystonia 的发病机制：目前的理论概念
Zi-Yi Li,Wo-Tu Tian,Xiao-Jun Huang et al.
Zi-Yi Li et al.
Paroxysmal kinesigenic dyskinesia (PKD) is a movement disorder characterized by recurrent and transient episodes of involuntary movements, including dystonia, chorea, ballism, or a combination of these, which are typically triggered by sudd...
Christmas-Related Reduction in Beta Activity in Parkinson's Disease [0.03%]
帕金森病患者的β频段脑电波活动在圣诞节时的减弱现象
Lucia K Feldmann,Roxanne Lofredi,Bassam Al-Fatly et al.
Lucia K Feldmann et al.
Background: Subthalamic nucleus (STN) beta (13 - 35 Hz) activity is a biomarker reflecting motor state in Parkinson's disease (PD). Adaptive deep brain stimulation (DBS) aims to use beta activity for therapeutic adjustmen...
Neuron-Derived Misfolded α-Synuclein in Blood: A Potential Biomarker for Parkinson's Disease? [0.03%]
血液中的神经源性错误折叠α-突触核蛋白：帕金森病的潜在生物标志物？
Linn Streubel-Gallasch,Philip Seibler
Linn Streubel-Gallasch
In Vivo Investigation of Glucose Metabolism in Idiopathic and PRKN-Related Parkinson's Disease [0.03%]
特发性和Parkin基因相关帕金森病患者糖代谢的体内研究
Max Borsche,Andre Märtens,Philipp Hörmann et al.
Max Borsche et al.
Background: Alterations in mitochondrial dysfunction have been implicated in the pathogenesis of Parkinson's disease (PD). Mitochondrial energy production is linked to glucose metabolism, and diabetes is associated with P...
The Monoamine Oxidase-B Inhibitor Selegiline Does Not Affect 18 F-Florzolotau Uptake in Patients with Progressive Supranuclear Palsy: A Longitudinal Case Series [0.03%]
单胺氧化酶B抑制剂司来吉兰不影响进行性核上性瘫患者氟卓硫酸tau摄取：一项纵向病例系列研究
Xin-Yi Li,Fang-Yang Jiao,Rui-Xin Yao et al.
Xin-Yi Li et al.