Treatment for Dyskinesia in Parkinson's Disease: A Network Meta-analysis of Randomized Controlled Trials [0.03%]
帕金森病运动障碍的治疗：随机对照试验的网络荟萃分析
Rui Yan,Xiaoqing Zheng,Yixuan Yin et al.
Rui Yan et al.
Background: Dyskinesia is a motor complication of Parkinson's disease (PD) posing therapeutic challenges. The optimal therapy for dyskinesia in PD has not been identified due to the lack of comprehensive evaluation of tre...
Long-Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients [0.03%]
帕金森病患者丘脑底核beta功率的空间分布及峰值动力学的长期稳定性研究
Jennifer K Behnke,Robert L Peach,Jeroen G V Habets et al.
Jennifer K Behnke et al.
Background: Subthalamic beta oscillations are a biomarker for bradykinesia and rigidity in Parkinson's disease (PD), incorporated as a feedback signal in adaptive deep brain stimulation with potential for guiding electrod...
José A Obeso,Anthony H V Schapira,Fabrizio Stocchi
José A Obeso
Deep Learning-Based Artificial Intelligence Algorithm to Classify Tremors from Hand-Drawn Spirals [0.03%]
基于深度学习的人工智能算法从手绘螺旋中分类震颤
Reghu Anandapadmanabhan,Aayushi Vishnoi,Geetha Raman et al.
Reghu Anandapadmanabhan et al.
Background: No objective biomarkers exist for diagnosing and classifying tremor syndromes. Objective: The aim was to develop and valida...
NLX-112 Randomized Phase 2A Trial: Safety, Tolerability, Anti-Dyskinetic, and Anti-Parkinsonian Efficacy [0.03%]
NLX-112随机二期A期试验：安全性，耐受性，抗异动性和抗帕金森病疗效
Per Svenningsson,Per Odin,Filip Bergquist et al.
Per Svenningsson et al.
Background: Levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) is associated with 'false neurotransmitter' release of dopamine from serotonin (5-HT) neurons. NLX-112 is a first-in-class, highly selective 5-HT1A...
Patients with Allan-Herndon-Dudley Syndrome (MCT8 Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment [0.03%]
患有 Allan-Herndon-Dudley 综合征（MCT8 缺乏）的患者在儿童期表现出帕金森症状并对左旋多巴/卡比多巴治疗有反应
Nina-Maria Wilpert,Angela L Hewitt,Roser Pons et al.
Nina-Maria Wilpert et al.
Background: Patients with mutations in the monocarboxylate transporter 8 (MCT8, SLC16A2) suffer from X-linked recessive Allan-Herndon-Dudley syndrome (AHDS), which is characterized by developmental delay and a severe move...
Brain Imaging Phenotypes Associated with Polygenic Risk for Essential Tremor [0.03%]
与特发性震颤多基因风险相关的脑影像表型特征研究
Miranda Medeiros,Alexandre Pastor-Bernier,Houman Azizi et al.
Miranda Medeiros et al.
Essential tremor (ET) is a common movement disorder with a strong genetic basis. Magnetic resonance imaging (MRI), particularly diffusion-weighted MRI (dMRI) and T1 MRI, have been used to identify brain abnormalities of ET patients. However...
Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain-Sense Study [0.03%]
精细调节的γ节律追踪帕金森病的药物周期：一项移动脑电感知研究
Aaron Colombo,Elena Bernasconi,Laura Alva et al.
Aaron Colombo et al.
Background: Novel commercial brain-sense neurostimulators enable us to contextualize brain activity with symptom and medication states in real-life ambulatory settings in Parkinson's disease (PD). Although various candida...
Treatment Efficacy of Theophylline in ADCY5-Related Dyskinesia: A Retrospective Case Series Study [0.03%]
茶碱对ADCY5相关性不自主运动障碍的治疗效果：一项回顾性病例系列研究
Dirk Taenzler,Frank Hause,Andreas Merkenschlager et al.
Dirk Taenzler et al.
Background: ADCY5-related dyskinesia is a rare disorder caused by mutations in the ADCY5 gene resulting in abnormal involuntary movements. Currently, there are no standardized guidelines to treat this condition. ...
Marie-Laure Welter,Jean-Christophe Corvol,Marco Romanato et al.
Marie-Laure Welter et al.