Stroke Etiologies With Intravenous Thrombolysis before Thrombectomy and Functional Outcomes in Anterior Circulation Large Vessel Occlusion [0.03%]
在前循环大血管闭塞接受机械取栓治疗的患者中，发病至穿刺时间对不同病因卒中的功能预后影响几何？
Changwei Guo,Fabiano Cavalcante,Shihai Yang et al.
Changwei Guo et al.
Objective: The benefit of intravenous thrombolysis (IVT) before endovascular treatment (EVT) in patients with acute ischemic stroke due to large vessel occlusion (LVO) who present directly to EVT-capable centers remains u...
Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative: myPPMI [0.03%]
帕金森病进展标志物计划虚拟研究环境的开发：myPPMI
Craig E Stanley Jr,Kimberly Fabrizio,Bridget A McMahon et al.
Craig E Stanley Jr et al.
In the 15 years since Parkinson's Progression Markers Initiative (PPMI) launched, research conduct has advanced with broader connectivity, enabling virtual and hybrid methods for recruitment, engagement, education, and data collection. To m...
Editorial
Annals of neurology. 2026 Apr 21. DOI:10.1002/ana.78230 2026
Partnering With Participant Advisors on the Parkinson's Progression Markers Initiative [0.03%]
帕金森病进展标志物计划中的参与者顾问合作模式
Maggie McGuire Kuhl,Christina Destro,Roseanne D Dobkin et al.
Maggie McGuire Kuhl et al.
Partnership with participants on study protocols and conduct informs study design, provides novel insights, and speeds enrollment and outcomes. The Parkinson's Progression Markers Initiative (PPMI) solicits volunteer inputs through a Commun...
Editorial
Annals of neurology. 2026 Apr 21. DOI:10.1002/ana.78220 2026
Use of Machine Learning to Identify Markers of Risk for Fragile X-Associated Tremor/Ataxia Syndrome: A Preliminary Analysis [0.03%]
机器学习在脆性X染色体综合征共核症/共运动障碍风险标志物识别中的应用初步分析
Chitrabhanu Gupta,Angeela Poudel,Jun Yi Wang et al.
Chitrabhanu Gupta et al.
Objective: The objective of this study was to examine whether machine learning has the capacity to prospectively identify and predict the emergence of Fragile X-associated tremor/ataxia syndrome (FXTAS) among male fragile...
Longitudinal Phenotypic Trajectories in GNAO1-Related Disorders: Defining Disease Progression and Clinical Profiles [0.03%]
GNAO1相关疾病的行为表型纵向轨迹：定义疾病进展和临床特征
Jana Domínguez-Carral,Ana María Domínguez Cobo,Sol Balsells et al.
Jana Domínguez-Carral et al.
Objective: Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longit...
Multimodal Image Guidance in Subthalamic Deep Brain Stimulation for Parkinson's Disease [0.03%]
帕金森病下丘脑深部脑刺激的多模态影像引导技术研究进展
Patricia Zvarova,Christina van der Linden,Ningfei Li et al.
Patricia Zvarova et al.
Objective: Accurate electrode placement and individual stimulation parameters influence the outcomes of subthalamic deep brain stimulation in Parkinson's disease. Neuroimaging-based models can help evaluate how electrode ...
Relapses, Comorbidities, and Predictors of Outcome in Anti-GABAA Receptor Encephalitis [0.03%]
抗GABA受体脑炎的复发、共病和预后指标
Claudia Papi,Chiara Milano,Laura Marmolejo et al.
Claudia Papi et al.
Objectives: To characterize the magnetic resonance imaging (MRI) lesion dynamics, comorbidities, predictors of relapse, and outcomes in anti-γ-aminobutyric acid type A receptor (GABAAR) encephalitis, and assess the utili...
Homozygous RFC1 AAGGG Repeat Expansions Are Common in Idiopathic Peripheral Neuropathy [0.03%]
RFC1纯合AAGGG重复序列扩张在特发性周围神经病中常见
Zitian Tang,Sinem S Ovunc,Ryo Iwase et al.
Zitian Tang et al.
Objective: Biallelic intronic AAGGG repeat expansions in RFC1 cause cerebellar ataxia with neuropathy and vestibular areflexia syndrome and may also contribute to isolated sensory neuropathy. The clinical significance of ...
Biochemical and Immunohistochemical Associations of TDP-43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease [0.03%]
TDP-43和隐秘RNA与阿尔茨海默病海马体和杏仁核体积的生化及免疫组织化学关联性研究
Hossam Youssef,Rodolfo G Gatto,Nikhil B Ghayal et al.
Hossam Youssef et al.
Objective: Immunohistochemically (IHC) measured transactive response DNA-binding protein 43 (TDP-43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation o...
Kate Durbano,Marie Belley,Delphine Leclercq et al.
Kate Durbano et al.