Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile [0.03%]
特发性颅内高压具有特征性的蛋白质组学谱型
Santosh D Bhosale,Arkadiusz Nawrocki,Johanne J Korsbæk et al.
Santosh D Bhosale et al.
Objectives: The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease-specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease-specific b...
Frequency- and Network-Specific Changes in Functional Connectivity Reflect Pathophysiological Mechanisms across Parkinson's Disease Stages [0.03%]
基于频率和网络的功能连接改变反映帕金森病各阶段的病理生理机制
Matteo Conti,Valentina D&#x;Onofrio,Luca Lorenzon et al.
Matteo Conti et al.
Objective: Parkinson's disease (PD) is increasingly conceptualized as a disorder of large-scale brain networks, yet whether and how frequency-specific functional connectivity reorganizes across stages remains poorly under...
Shotgun Metagenomic Profiling of the Gut Virome in Prodromal and Confirmed Parkinson's Disease [0.03%]
帕金森病前驱期和确诊患者的肠道病毒组宏基因组分析
Deepika Dinesh,Xochitl C Morgan,Jordan Jensen et al.
Deepika Dinesh et al.
We conducted a nested case-control study within the Nurses' Health Study and the Health Professionals Follow-up Study to examine the role of the gut virome (GV) in Parkinson's disease (PD). We applied a novel metagenomic virome profiling ap...
Genetic-Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis [0.03%]
基因蛋白组整合鉴定出预测多发性硬化症的血浆蛋白
Yuan Ding,Dylan Hamitouche,Simon Thebault et al.
Yuan Ding et al.
Objective: Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to ident...
Outcomes in Long-Term Follow-Up of Sporadic Parkinson's Disease in the Parkinson's Progression Markers Initiative [0.03%]
帕金森病进展标志物计划中散发性帕金森病长期随访的转归情况
Paulina Gonzalez-Latapi,Caroline Gochanour,Seung Ho Choi et al.
Paulina Gonzalez-Latapi et al.
The Parkinson's Progression Markers Initiative (PPMI) has addressed a key gap in the availability of long-term longitudinal data in sporadic Parkinson's disease (sPD) with extensive biological characterization. With biological characterizat...
Editorial
Annals of neurology. 2026 May 18. DOI:10.1002/ana.78248 2026
Continuous Versus Short EEG After Ischemic Stroke: What cEEG Adds for Detecting Abnormalities and Predicting Post-Stroke Epilepsy [0.03%]
持续与短程脑电图在缺血性卒中后的应用：连续视频脑电监测对发现脑电异常和预测卒中后癫痫的价值是什么？
Kai Michael Schubert,Vijaya Dasari,Chiara Tatillo et al.
Kai Michael Schubert et al.
Objective: The objective of this study was to quantify incremental diagnostic yield and prognostic value of continuous electroencephalography (cEEG; ≥12 hours) versus a 60-minute short electroencephalography (sEEG) in pr...
Diagnostic, Prognostic Value, and Pathological Associations of Levodopa Responsiveness in Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy [0.03%]
帕金森病、多系统萎缩和进行性核上性麻痹的左旋多巴治疗反应的诊断、预后价值及其病理学关联
Vitor Maia Arca,Justina Jurkeviciene,Patrick Cullinane et al.
Vitor Maia Arca et al.
Objective: The objective of this study was to provide clinical and pathological characterization, and evaluation of the diagnostic and prognostic implications of levodopa response in Parkinson's disease (PD), multiple sys...
Identification and Enrollment of Individuals Prior to Parkinson's Disease Diagnosis: Biomarker-Driven Adaptive Eligibility and Enrollment into the Parkinson's Progression Markers Initiative [0.03%]
帕金森病诊断前个体的识别和纳入：生物标志物驱动的适应性纳入Parkinson's Progression Markers Initiative的资格和纳入标准
Ethan G Brown,Lana M Chahine,Roseanne D Dobkin et al.
Ethan G Brown et al.
To better understand the earliest stages of alpha-synucleinopathy, the Parkinson's Progression Markers Initiative (PPMI) has enrolled participants prior to the diagnosis of Parkinson's disease (PD) or dementia with Lewy Bodies (DLB). In thi...
Editorial
Annals of neurology. 2026 May 14. DOI:10.1002/ana.78246 2026
Cognitive Impairment in Parkinson's Disease: Contributions from the Parkinson's Progression Markers Initiative [0.03%]
帕金森病认知障碍：来自帕金森进展标志物计划的贡献
Daniel Weintraub,Roseanne D Dobkin,Michele K York et al.
Daniel Weintraub et al.
Cognitive impairment is a core feature of neuronal synuclein disease (NSD) across the Parkinson's disease (PD) continuum, emerging in prodromal states and progressing variably after diagnosis. Leveraging Parkinson's Progression Markers Init...
Editorial
Annals of neurology. 2026 May 13. DOI:10.1002/ana.78254 2026
Daily-Life, Sensor-Derived Tremor Measures Are Sensitive to Progression in Early Parkinson's Disease [0.03%]
日常生活中基于传感器的震颤测量方法可敏感地反映帕金森病早期病情进展状况
Nienke A Timmermans,Ioan Gabriel Bucur,Diogo C Soriano et al.
Nienke A Timmermans et al.
Objective: Sensitive outcome measures are critical for evaluating the efficacy of novel treatments for Parkinson's disease (PD). In this study, we assess the sensitivity to change of sensor-derived daily-life tremor measu...