Individualized Treatment in Distal and Medium Vessel Occlusion Stroke Using a Validated Explainable Counterfactual Treatment Estimation Model [0.03%]
基于验证的可解释反事实治疗方法估计模型的远端和中等血管闭塞卒中的个体化治疗
Mohamed F Doheim,Mahmoud H Mohammaden,Hend Abdelhamid et al.
Mohamed F Doheim et al.
Objective: The optimal treatment for distal medium vessel occlusion (DMVO) stroke remains uncertain, and evidence comparing endovascular therapy (EVT) with medical management (MM) is limited. We aimed to develop and valid...
Severe, Non-apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures [0.03%]
全身强直阵挛性发作后严重非阻塞性呼吸功能障碍和低氧血症
Haley E Pysick,Rup K Sainju,Roshni Nair et al.
Haley E Pysick et al.
Objective: Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently ...
Stop the Spin: Confronting Reporting Bias in Multiple Sclerosis Research [0.03%]
揭穿谎言： confronting reporting bias in multiple sclerosis research中的报道偏见应对多发性硬化症研究
Dennis Bourdette,Elizabeth Silbermann
Dennis Bourdette
Distortion in the Communication of Nonsignificant Primary Outcomes: The Spin Strategy in Multiple Sclerosis Trials [0.03%]
多重硬化症研究中的数据包装策略：对非显著性主要结果的曲解报道
Marta Mascareñas-García,Alejandro Rivero-de-Aguilar,Cristina Candal-Pedreira et al.
Marta Mascareñas-García et al.
Objective: Spin refers to reporting strategies that highlight the benefits of an experimental treatment or divert attention from nonsignificant primary outcomes. To assess spin in randomized clinic trials (RCTs) on pharma...
Enhanced Sensitivity of a Modified Quaking-Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study [0.03%]
改良的震颤诱导转化诊断试验检测 sporadic 和遗传性 prion 病的高灵敏度：一项回顾性研究
Jennifer Myskiw,Rebecca Fox,Dominic M S Kielich et al.
Jennifer Myskiw et al.
Objective: Quaking-induced conversion (QuIC) tests, which detect prion-seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt-Jakob disease (CJ...
Revisiting Incomplete Tissue-Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke [0.03%]
急性缺血性卒中成功取栓后不完全的组织水平再灌注的再评估
Yue Qiao,Adrien Ter Schiphorst,Yi Xu et al.
Yue Qiao et al.
Among patients with acute ischemic stroke achieving successful large vessel recanalization (defined as expanded Thrombolysis in Cerebral Infarction [eTICI ≥2b]), incomplete tissue-level reperfusion, distinct from visually identifiable dist...
When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ-PET Centiloid 15, Mean Age of 66 Years [0.03%]
阿尔茨海默病始于何时？淀粉样蛋白PET评分15（平均年龄66岁）处，外周血Aβ42/40比值骤变
Rodrigo Cánovas,Timothy Cox,Vincent Doré et al.
Rodrigo Cánovas et al.
Objective: Sporadic late-onset Alzheimer's disease (AD) is characterized by a long pre-clinical phase where amyloid-beta (Aβ) and tau begin to accumulate in the brain. The primary objective was to determine the age at wh...
Samira A Maboudian,Corrina S Fonseca,Adam C Martersteck et al.
Samira A Maboudian et al.
Objective: Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether...
Confined B-Cell Reconstruction and High T-Cell Clonality Define Clinical Response to Cladribine Treatment [0.03%]
克拉屈滨治疗的临床反应定义为封闭B细胞重建和高T细胞克隆性
Tilman Schneider-Hohendorf,Maria Eveslage,Timo Wirth et al.
Tilman Schneider-Hohendorf et al.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B- an...
Novel Aggressive Subtype of Multiple System Atrophy Identified by Unsupervised Machine Learning [0.03%]
无监督机器学习识别出的一种多系统萎缩的新侵袭性亚型
Hiroaki Sekiya,Daisuke Ono,Alexia R Maier et al.
Hiroaki Sekiya et al.
Objectives: Multiple system atrophy (MSA) is classified into parkinsonian (MSA-P) and cerebellar (MSA-C) phenotypes based on predominant motor features, with corresponding pathological classifications of striatonigral (SN...