Biologic Frameworks for Synucleinopathies: Contributions of the Parkinson's Progression Markers Initiative [0.03%]
皮层纹状体tauopathy的生物学框架：Parkinson病进展标志物计划的贡献
Lana M Chahine,Roy N Alcalay,Ethan G Brown et al.
Lana M Chahine et al.
A research biologic definition and staging of neuronal alpha-synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, is critical toward improving clinical trial design and drug development. Neuronal synuclein disease...
Editorial
Annals of neurology. 2026 May 6. DOI:10.1002/ana.78249 2026
From Parkinson's Progression Markers Initiative to Parkinson's Precision Medicine Initiative: Still PPMI [0.03%]
从帕金森病进展标志计划到精准医疗计划：依然是PPMI项目
Kenneth Marek,Sohini Chowdhury,Thomas F Tropea;Parkinson&#x;s Progression Markers Initiative
Kenneth Marek
The Parkinson's Progression Marker Initiative (PPMI), sponsored by The Michael J. Fox Foundation for Parkinson's Research, is designed to develop disease biomarkers to accelerate Parkinson's disease (PD) therapeutics. During the past 15 yea...
Editorial
Annals of neurology. 2026 May 5. DOI:10.1002/ana.78242 2026
Pre-Diagnostic Plasma Carotenoids, Tocopherols and Retinol Levels, and Risk of Amyotrophic Lateral Sclerosis [0.03%]
渐冻症的发病风险与血液类胡萝卜素、生育酚和维生素A水平之间的关系
Éilis J O&#x;Reilly,Kjetil Bjornevik,Jeremy D Furtado et al.
Éilis J O&#x;Reilly et al.
Objective: Our goal was to examine whether pre-diagnostic plasma carotenoids and tocopherols are associated with amyotrophic lateral sclerosis (ALS). Meth...
Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers [0.03%]
多病共存及其与认知和阿尔茨海默病生物标志物的相关性
Xiaqing Jiang,Sid E O&#x;Bryant,Robert A Rissman et al.
Xiaqing Jiang et al.
Objective: Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD-related dementias, yet the mechanisms remain unclear. We aimed to examine ...
Hematoma Interleukin-1 Receptor Antagonist Concentrations Predict Long-Term Outcome in Acute Human Intracerebral Hemorrhage [0.03%]
急性人类脑内出血中血肿白细胞介素-1受体拮抗剂浓度可预测长期预后
Adrian R Parry-Jones,Blessing Nyakutsikwa,Michael H Askenase et al.
Adrian R Parry-Jones et al.
Objectives: The interleukin (IL)-1, IL-6, and C-reactive protein (CRP) pathway is central to the immune response after intracerebral hemorrhage (ICH). We tested for associations between hematoma and plasma cytokine concen...
The IL-1β-STING Signaling Axis Drives Neuromyelitis Optica Pathogenesis in a Murine Model [0.03%]
白细胞介素IL-1β-STING信号轴通过小鼠模型驱动神经肌炎谱系光学病的发病机制
Siyu Han,Ziqi Liang,Chongyou Zhang et al.
Siyu Han et al.
Objective: Neuromyelitis optica (NMO) is a severe autoimmune disorder of the central nervous system (CNS) characterized by aquaporin-4 antibody (AQP4-IgG)-mediated astrocyte injury. IL-1β-mediated inflammatory signaling ...
Return of Individual Research Information in the Parkinson's Progression Markers Initiative [0.03%]
帕金森病进展标志物计划中的个体研究信息反馈
Thomas F Tropea,Kathryn Brodkin,Michael C Brumm et al.
Thomas F Tropea et al.
The commitment of Parkinson's Progression Markers Initiative participants to longitudinal comprehensive clinical and biomarker research assessment is key to its success in acquiring high quality data. As the study has evolved, it has become...
Editorial
Annals of neurology. 2026 Apr 29. DOI:10.1002/ana.78228 2026
Cerebrospinal Fluid Amyloid-β Biomarkers Predict Future Hemorrhage in Patients with Cerebral Amyloid Angiopathy [0.03%]
脑淀粉样变性血管病患者的脑脊液淀粉样蛋白-β生物标志物可预测未来出血风险
Philipp Arndt,Malte Pfister,Valentina Perosa et al.
Philipp Arndt et al.
Objective: Accurately predicting future hemorrhagic events in patients with cerebral amyloid angiopathy (CAA) remains a major clinical challenge. It is unknown whether cerebrospinal fluid (CSF) biomarkers of amyloid-beta ...
Tatiana Foroud,Laura E A Heathers,Syed Bukhari et al.
Tatiana Foroud et al.
Brain autopsy plays a critical role advancing understanding of neurological conditions, providing unique insights that may otherwise not be captured through studies of living individuals. In addition, given our increasing reliance on biomar...
Editorial
Annals of neurology. 2026 Apr 26. DOI:10.1002/ana.78229 2026
Zhen Wang,Xingwen Wang,Junjie Li et al.
Zhen Wang et al.