Age Is an Effect Modifier of Thrombectomy Benefit in a Socioeconomically Vulnerable Stroke Population [0.03%]
年龄是血栓切除术在脆弱人群中疗效的调制因素
Fabricio O Lima,Francisco José de A Mont&#x;Alverne,Letícia C Rebello et al.
Fabricio O Lima et al.
Objective: Randomized trials from high-income countries have shown that endovascular treatment (EVT) yields similar benefits in elderly and non-elderly patients with large vessel occlusion stroke (LVOS). However, evidence...
Neurotransmitter-Defined Degeneration Patterns in Sporadic and C9orf72-Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems-Implications for Therapy Development [0.03%]
散发性和C9orf72相关性肌萎缩侧索硬化症中由神经递质定义的退行性病变模式：针对GABA能、血清素能、阿片类、谷氨酸能、内源大麻素和小胶质细胞系统的好发性-对疗法开发的意义
Marlene Tahedl,We Fong Siah,Jasmin Lope et al.
Marlene Tahedl et al.
Objective: Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The mole...
Jennifer Vermilion,Sabrina Paganoni,Scott R Plotkin et al.
Jennifer Vermilion et al.
Master protocol trials allow for simultaneous multiple hypothesis testing within a common framework and might be applicable for rare diseases. In May 2025, the Network for Excellence in Neuroscience Clinical Trials convened a multistakehold...
Monitoring Antiseizure Medication Change Using Ultra Long-Term Electroencephalogram: A Multicenter Study [0.03%]
利用超长程脑电图监测抗癫痫药物变化的多中心研究
Pedro F Viana,Matthew McWilliam,Johannes Koren et al.
Pedro F Viana et al.
Objective: Medication dose adjustments are common in treatment-resistant epilepsy, but lack robust evidence, and patient-reported seizure diaries have known limitations. We assessed whether ultra long-term subcutaneous el...
Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System [0.03%]
人脑和外周神经系统的巨Tau异构体分布
Rama Krishna Koppisetti,Nicolas R Barthélemy,Kanta Horie et al.
Rama Krishna Koppisetti et al.
Objective: Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, "big tau," produced by inclusion of exon 4a, is expressed in the peripheral nervous syste...
Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression [0.03%]
血管周围间隙在淀粉样蛋白、tau和血管生物标志物进展中的作用
Audrey Low,Jeffrey L Gunter,Mingzhao Hu et al.
Audrey Low et al.
Objective: Magnetic resonance imaging (MRI)-visible enlarged perivascular spaces (PVS) are markers of cerebral small vessel disease (SVD) and aging, processes implicated in both neurodegenerative and cerebrovascular patho...
Change in Amyloid-β Deposition and Diffusion Tensor Image Analysis along the Perivascular Space Index in Incident Neurodegenerative Disease [0.03%]
新发神经退行性疾病的淀粉样蛋白沉积及沿脑小血管周围间隙指数的扩散张量成像分析的变化规律研究
Sewon Lim,Youngjin Lee,Chang-Soo Yun et al.
Sewon Lim et al.
Objective: We investigated the longitudinal association between cognitive decline, amyloid-β deposition, and perivascular diffusivity using diffusion tensor image analysis along the perivascular space (DTI-ALPS) index. ...
Maternal-Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy [0.03%]
利司扑兰母胎治疗可部分改善脊髓性肌萎缩症SMNΔ7小鼠模型症状
Emma R Sutton,Ariane Beauvais,Rebecca Yaworski et al.
Emma R Sutton et al.
Objective: Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is cha...
Comparative Seizure Outcomes of Vagus Nerve Stimulation, Deep Brain Stimulation, and Their Combination in Lennox-Gastaut Syndrome [0.03%]
Lennox-Gastaut综合征迷走神经刺激、深部脑刺激及其联合治疗的比较研究
Cheng-Yen Kuo,Raunak Singh,Shelja Sharma et al.
Cheng-Yen Kuo et al.
Objective: Lennox-Gastaut syndrome (LGS) is a severe treatment-resistant epilepsy. Although vagus nerve stimulation (VNS) and deep brain stimulation (DBS) are established therapies, comparative data and the impact of dual...
Ye Han,Ping Zheng,Xinna Ji et al.
Ye Han et al.