Hyperreflective Foci in the Inner Nuclear Layer: Proof-of-Concept for an Optical Coherence Tomography Derived Microglia-Related Marker in Multiple Sclerosis [0.03%]
高强度聚焦成像内核层：多重硬化症相关的光学相干断层扫描派生微胶质细胞标志物的概念验证研究
Jonathan A Gernert,Laura M Bartos,Tara Christmann et al.
Jonathan A Gernert et al.
The role of microglia has emerged as a critical driver of disease progression in multiple sclerosis (MS), but we lack broadly applicable monitoring tools. Here, we investigated whether hyperreflective foci (HRF), as detected by optical cohe...
Reply to "Comparative Safety Profiles of Ocrelizumab and Rituximab in Multiple Sclerosis Treatment Using Real-World Evidence" [0.03%]
对“利用真实世界证据比较ocrelizumab与rituximab治疗多发性硬化症的安全性特征”的答复
Gabriel Cerono,Bruce A C Cree,Stephen L Hauser et al.
Gabriel Cerono et al.
Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood-Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors [0.03%]
RESTLESS LEGS综合症脑脊液通过干扰转铁蛋白受体调控来减少血脑屏障内皮细胞对铁的摄取
Kondaiah Palsa,Aurosman Pappus Sahu,David B Rye et al.
Kondaiah Palsa et al.
Objective: Restless legs syndrome (RLS) is a sensorimotor disorder marked by an uncontrollable urge to move the legs. A pathophysiological hallmark of RLS is brain iron deficiency. The endothelial cells (ECs) of the blood...
Supratentorial Brain Lesions in Unconscious Patients Map to a Common Human Brain Circuit [0.03%]
无意识患者大脑的顶上病变映射到一个共同的人类大脑回路中
Joshua Kahan,Rafael Vignoli Lippert,Bassam Al-Fatly et al.
Joshua Kahan et al.
Objective: Impairment of consciousness is frequent in patients with supratentorial brain injury, but underlying mechanisms are poorly understood. Large-scale network dysfunction has been suggested as a unifying concept fo...
Network Colocalization Correlates of Depression and Anxiety in Pediatric Focal Cortical Dysplasia-Related Epilepsy [0.03%]
儿童局灶性皮质发育不良相关癫痫中抑郁和焦虑的网络共定位相关因素
Xiaotong Li,Ty Charde,Venkata Sita Priyanka Illapani et al.
Xiaotong Li et al.
Objective: Focal cortical dysplasia (FCD) is the most common cause of surgically treatable, drug-resistant epilepsy in children. Anxiety and depression are frequent comorbidities in epilepsy. This study examined whether F...
Combination Disease-Modifying Therapy for Neurodegenerative Diseases Using Repurposed Drugs [0.03%]
老药新用治疗神经退行性疾病组合疗法研究进展
Alexander Shtilbans,Anthony E Lang
Alexander Shtilbans
We review the positive effects of several existing drugs from different classes, such as chemical chaperones, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), iron chelators, and cluster-Abelson tyrosine kinase inhibitors (c-Abl TKIs)...
Effects of Blood Pressure Lowering Across Hematoma Volume in Acute Intracerebral Hemorrhage: Pooled Analysis of the Four INTERACT and ATACH-2 Trials [0.03%]
基于INTERACT和ATACH-2四项试验的急性脑出血患者降血压治疗效果：不同血肿量患者的亚组荟萃分析
Xinwen Ren,Qiang Li,Menglu Ouyang et al.
Xinwen Ren et al.
Objective: The objective of this study was to assess the heterogeneity in treatment effect of intensive blood pressure (BP)-lowering across hematoma volume after acute intracerebral hemorrhage (ICH). ...
Odile Feys,Julia Makhalova,Samuel Medina Villalon et al.
Odile Feys et al.
Objective: In temporal lobe epilepsy (TLE), the amygdala in the epileptogenic network is underestimated compared to other regions such as the hippocampus. Recent advances in anatomical neuroimaging and stereoelectroenceph...
Shervin Pejhan,Adrian Budhram,Robert Hammond et al.
Shervin Pejhan et al.