Outcomes of Intra-Arterial Tenecteplase after Endovascular Reperfusion for Acute Ischemic Stroke Due to Cardioembolism and Non-Cardioembolism: A Secondary Analysis of the POST-TNK Trial [0.03%]
替奈普酶溶栓治疗心源性和非心源性急性缺血性卒中的血管内再灌注的疗效：POST-TNK试验的事后分析研究结果
Miao Chai,Qin Zhang,Xuexiao Zhao et al.
Miao Chai et al.
Objective: This study aimed to evaluate the safety and effectiveness of adjunctive intra-arterial tenecteplase (TNK) in patients with acute ischemic stroke (AIS) due to cardioembolism (CE) and non-CE who achieved near-com...
A Human Gait Circuit Derived from Brain Lesions and Deep Brain Stimulation [0.03%]
基于脑损伤和深部脑刺激提取的人类步态环路
Lan Luo,Frederic L W V J Schaper,Michael Nguyen et al.
Lan Luo et al.
Objectives: The human neuroanatomy for gait dysfunction remains unclear. We sought (1) to identify a brain circuit for gait impairment post stroke, (2) to identify a brain circuit for gait changes after subthalamic deep b...
Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk [0.03%]
ABCA1基因修饰与APOE等位基因相互作用调节阿尔茨海默病风险
Andrés Peña-Tauber,Ricardo Hernández Arriaza,Dylan Reil et al.
Andrés Peña-Tauber et al.
Objective: ATP-binding cassette transporter A1 (ABCA1) has been associated with Alzheimer's disease (AD), but the mechanisms by which it impacts disease risk are unknown. ABCA1 is known to bind apolipoprotein E (ApoE) and...
Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3 [0.03%]
建立感觉神经元作为外周神经病的治疗靶点——由多聚谷氨酰胺扩增的小鼠ATXN3引起的外周神经病研究
Juan P Mato,John M Hayes,Jacen Emerson et al.
Juan P Mato et al.
Objective: Repeat expansion mutations underlie diverse neurogenetic disorders, many involving the peripheral nervous system. Despite peripheral neuropathy being the most common neurological disorder worldwide, its contrib...
Two Years of Ocrelizumab Treatment in Black and Hispanic People with Multiple Sclerosis in CHIMES: A Single-Arm Clinical Trial [0.03%]
CHIMES研究中奥克雷珠单抗治疗两年的黑人和西班牙籍多发性硬化患者的疗效：一项单臂临床试验
Lilyana Amezcua,Anthony T Reder,Evanthia Bernitsas et al.
Lilyana Amezcua et al.
Objective: To evaluate the effectiveness and safety of ocrelizumab in self-identified black and Hispanic people with relapsing multiple sclerosis. Methods...
Francesca Palumbo,Barbara Iazzolino,Cristina Moglia et al.
Francesca Palumbo et al.
Objective: Behavioral impairment is common in amyotrophic lateral sclerosis (ALS) and strongly affects autonomy, caregiver burden, and outcomes, yet predictors of vulnerability remain unclear. We investigated whether prem...
Sanem Pinar Uysal,Ciersten A Burks,Rex N Smith et al.
Sanem Pinar Uysal et al.
Blood Biomarkers of Alzheimer's Disease and Patterns of Structural Brain Changes in the Community [0.03%]
社区人群阿尔茨海默病血浆生物标志物与脑结构变化模式的关系研究
Martina Valletta,Davide Liborio Vetrano,Erika J Laukka et al.
Martina Valletta et al.
Objective: We aimed to investigate the associations between Alzheimer's disease (AD)-related blood biomarkers and changes in brain volumes and cerebrovascular burden in community-dwelling older adults. ...
Outcomes of Bilateral Globus Pallidus Internus Deep Brain Stimulation in GNAO1-Related Disorder: An International Multicenter Experience [0.03%]
双侧内苍白球深部脑刺激治疗GNAO1相关障碍的疗效：国际多中心经验
Katerina Bernardi,Josh Rong,Weston T Northam et al.
Katerina Bernardi et al.
Objective: GNAO1-related disorder is a severe childhood-onset hyperkinetic movement disorder punctuated by life-threatening dyskinetic crises. Small series suggest benefit from bilateral globus pallidus internus deep brai...
Regional and Compartmental Changes Drive Progressive Patterns of Striatal Degeneration in X-Linked Dystonia Parkinsonism [0.03%]
X连锁肌张力不全性帕金森病中区域和隔室变化驱动纹状体变性的进展模式
Adelie Y S Tan,Nakhon S S S Thai,Christine J Arasaratnam et al.
Adelie Y S Tan et al.
Objective: Initially described in 1976, X-linked dystonia parkinsonism (XDP) is a neurodegenerative disease that can be characterized by the presentation of dystonia and parkinsonism symptoms. Although this disease bears ...