Jayant A Talwalkar
Jayant A Talwalkar
Purpose of review: This article examines recent health services and policy research studies in hepatology and liver transplantation. Recent findings: ...
Simon Hazeldine,Nick Sheron
Simon Hazeldine
Purpose of review: The burden of alcohol on global health is increasing, and there is a strong relationship between population alcohol consumption and liver-related deaths. As alcohol-related liver disease (ArLD) often de...
Frans J C Cuperus,Emina Halilbasic,Michael Trauner
Frans J C Cuperus
Purpose of review: Primary biliary cirrhosis (PBC) can lead to end-stage liver disease and death. Ursodeoxycholic acid (UDCA) treatment can normalize serum liver enzymes in PBC, and such UDCA-responsive patients have a si...
Mitchell L Shiffman
Mitchell L Shiffman
Purpose of review: The evolution of treatment for patients with chronic hepatitis C virus (HCV) is evolving at a rapid pace. Two new oral antiviral agents, simeprevir and sofosbuvir, have already been approved and are now...
Jason M Ridlon,Dae J Kang,Phillip B Hylemon et al.
Jason M Ridlon et al.
Purpose of review: We examine the latest research on the emerging bile acid-gut microbiome axis and its role in health and disease. Our focus revolves around two key microbial pathways for degrading bile salts, and the im...
Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma [0.03%]
IDH1和IDH2基因突变在肝内胆管癌中的意义研究
Alexandra R Grassian,Raymond Pagliarini,Derek Y Chiang
Alexandra R Grassian
Purpose of review: Exome sequencing studies have recently expanded the genetic characterization of intrahepatic cholangiocarcinomas. Among a number of novel genes, isocitrate dehydrogenase (IDH) is recurrently mutated in ...
Eva K K Henriksen,Espen Melum,Tom H Karlsen
Eva K K Henriksen
Purpose of review: The pathogenesis of primary sclerosing cholangitis (PSC) involves heritable factors. This review summarizes the recent genetic studies and discusses the implications of identified risk loci. ...
Jose J G Marin,Luis Bujanda,Jesus M Banales
Jose J G Marin
Purpose of review: To highlight the increasing evidence supporting the concept that microRNAs (miRNAs) are involved in the cause and pathogenesis of cholestatic liver disorders. ...
Ronald L Koretz
Ronald L Koretz
Purpose of review: Although there is a well established association between malnutrition and poorer clinical outcomes in patients with liver disease, that fact alone does not prove that improving the malnutrition will imp...
Susan A Joyce,Cormac G M Gahan
Susan A Joyce
Purpose of review: It is clear that the metabolic activities of the gut microbiota significantly impact upon human health and disease. Recent findings: ...