Startups and the next frontier of inflammatory bowel disease therapy: a guide for the brave [0.03%]
创业公司与炎症性肠病治疗的下一个前沿：勇敢者的指南
Vladimir Lamm
Vladimir Lamm
Purpose of review: This review explores the evolving landscape of inflammatory bowel disease (IBD) therapy, particularly through the lens of startups that are pushing the boundaries of current treatment paradigms. By disc...
Miguel A Algara,Walter W Chan
Miguel A Algara
Purpose of review: Chronic laryngopharyngeal symptoms (LPS) are increasingly prevalent presentations to gastroenterologists' offices, and clinicians often make a presumptive diagnosis of laryngopharyngeal reflux disease (...
Babu Lal Meena,Omkar S Rudra,Deepti Sharma et al.
Babu Lal Meena et al.
Purpose of review: Noncirrhotic portal hypertension (NCPH) comprises a diverse group of vascular liver disorders characterized by elevated portal pressure without cirrhosis. Due to overlapping clinical features, distingui...
Christina Kratschmer,David T Curiel,Matthew A Ciorba
Christina Kratschmer
Purpose of review: Tissue-directed therapies (TDTs) provide potential advantages, including improved tolerance, safety, and efficacy. This review provides a conceptual framework for understanding intestinal TDT and summar...
Ayesh Awad,Aaron J Alcala,Martis W Cowles et al.
Ayesh Awad et al.
Purpose of review: Chromatin plays a critical role in gene regulation and disease pathogenesis. In inflammatory bowel disease (IBD), alterations in chromatin structure contribute to disease heterogeneity and impact treatm...
Advancing care in malignant gastric outlet obstruction: a contemporary review of management strategies [0.03%]
恶性胃出口梗阻的治疗进展：管理策略的当代回顾
Adrianna Wierzbicka,Tilak Shah
Adrianna Wierzbicka
Purpose of review: The aim of this review is to summarize the most pertinent data on management of malignant gastric outlet obstruction (MGOO), with an emphasis on recent updates. ...
Kevin J Wang,Evelyn V Alexander,Stephanie G Worrell
Kevin J Wang
Purpose of review: The management of esophageal perforation is a topic of debate, as there now are viable surgical and endoscopic options. Historically, surgical management had been considered the standard of care for the...
Hematopoietic stem cell transplantation in Crohn's disease: a comprehensive review [0.03%]
克罗恩病的造血干细胞移植：全面回顾
Akshita Gupta,Elena Ricart,Louis Cohen
Akshita Gupta
Purpose of review: Despite advances in medical therapies for the treatment of Crohn's disease (CD), 20-30% of patients fail to respond to these therapies (i.e. refractory CD). Medically refractory CD leads to significant ...
Jad Allam,Don C Rockey
Jad Allam
Purpose of review: No universal consensus exists as to what the upper limit of normal for alanine aminotransferase (ALT) should be. The purpose of this review is to provide insight on the wide variation in the upper limit...
Austin D Peer,Jennifer C Price
Austin D Peer
Purpose of review: Despite the efficacy of direct-acting antiviral (DAA) therapy, hepatitis C virus (HCV) remains a significant contributor to liver-related morbidity and mortality. This review summarizes the approach to ...