Ayesh Awad,Aaron J Alcala,Martis W Cowles et al.
Ayesh Awad et al.
Purpose of review: Chromatin plays a critical role in gene regulation and disease pathogenesis. In inflammatory bowel disease (IBD), alterations in chromatin structure contribute to disease heterogeneity and impact treatm...
Advancing care in malignant gastric outlet obstruction: a contemporary review of management strategies [0.03%]
恶性胃出口梗阻的治疗进展：管理策略的当代回顾
Adrianna Wierzbicka,Tilak Shah
Adrianna Wierzbicka
Purpose of review: The aim of this review is to summarize the most pertinent data on management of malignant gastric outlet obstruction (MGOO), with an emphasis on recent updates. ...
Kevin J Wang,Evelyn V Alexander,Stephanie G Worrell
Kevin J Wang
Purpose of review: The management of esophageal perforation is a topic of debate, as there now are viable surgical and endoscopic options. Historically, surgical management had been considered the standard of care for the...
Hematopoietic stem cell transplantation in Crohn's disease: a comprehensive review [0.03%]
克罗恩病的造血干细胞移植：全面回顾
Akshita Gupta,Elena Ricart,Louis Cohen
Akshita Gupta
Purpose of review: Despite advances in medical therapies for the treatment of Crohn's disease (CD), 20-30% of patients fail to respond to these therapies (i.e. refractory CD). Medically refractory CD leads to significant ...
Jad Allam,Don C Rockey
Jad Allam
Purpose of review: No universal consensus exists as to what the upper limit of normal for alanine aminotransferase (ALT) should be. The purpose of this review is to provide insight on the wide variation in the upper limit...
Austin D Peer,Jennifer C Price
Austin D Peer
Purpose of review: Despite the efficacy of direct-acting antiviral (DAA) therapy, hepatitis C virus (HCV) remains a significant contributor to liver-related morbidity and mortality. This review summarizes the approach to ...
Who and how to choose combination therapy for inflammatory bowel disease: a comprehensive expert review [0.03%]
炎症性肠病的联合治疗如何选择及如何实施：全面专家回顾
Alessandro David,Chakib Rekkabi,Annissa Fournier et al.
Alessandro David et al.
Purpose of review: Therapeutic options in inflammatory bowel disease (IBD) have expanded significantly. Patients often experience primary or secondary loss of response to biologics or small molecules therapy. Determining ...
Kimberley Butler,Thomas Peachey,Reena Sidhu et al.
Kimberley Butler et al.
Purpose of review: Meckel's diverticulum (MD) is a common congenital ileal diverticulum. Whilst mostly asymptomatic, 4-9% develop complications, such as small bowel obstruction, diverticulitis or bleeding. In 1933, Charle...