Diagnosis and management of immune mediated liver injury from checkpoint inhibitors [0.03%]
检查点抑制剂引起的免疫介导性肝损伤的诊断和处理
Alisa Likhitsup,Robert J Fontana
Alisa Likhitsup
Purpose of review: The aim is to summarize the latest data on the incidence, clinical manifestations, and management of immune- mediated liver injury from checkpoint inhibitors (ILICI). ...
M R Pedersen,Marlyn J Mayo
M R Pedersen
Purpose of review: The primary therapy of autoimmune hepatitis (AIH) has been established for over three decades. This review focuses on updates in the evaluation and management of patients with AIH. ...
David Schöler,Bernd Schnabl
David Schöler
Purpose of review: The intestinal microbiome and the gut-liver axis play a major role in health and disease. The human gut harbors trillions of microbes and a disruption of the gut homeostasis can contribute to liver dise...
Florence Wong
Florence Wong
Purpose of review: The definition and diagnostic criteria of hepatorenal syndrome-acute kidney injury (HRS-AKI) has undergone recent changes. A major vasoconstrictor, terlipressin, has recently been approved as pharmacoth...
Nicoletta Nandi,Foong Way David Tai,Mark McAlindon et al.
Nicoletta Nandi et al.
Purpose of review: Isolated terminal ileitis is an increasing phenomenon identified during colonoscopy. Idiopathic terminal ileitis (IDTI) is a diagnosis of exclusion, representing a significant challenge from a diagnosti...
Hersh Shroff
Hersh Shroff
Purpose of review: The rapid rollout and uptake of novel coronavirus disease 2019 (COVID-19) vaccines has been accompanied by a small yet noticeable accumulation of reports of liver injury occurring after vaccination. Thi...
Biliary stem cells in health and cholangiopathies and cholangiocarcinoma [0.03%]
胆干干细胞在健康及胆管疾病和胆管癌中的作用
Vincenzo Cardinale,Savino Paradiso,Domenico Alvaro
Vincenzo Cardinale
Purpose of review: This review discusses evidence regarding progenitor populations of the biliary tree in the tissue regeneration and homeostasis, and the pathobiology of cholangiopathies and malignancies. ...
Chantal Housset
Chantal Housset
Postoperative small bowel Crohn's disease: how to diagnose, manage and treat [0.03%]
术后小肠克罗恩病：如何诊断、管理和治疗
Chak Lam Ip,Ray Boyapati,Rahul Kalla
Chak Lam Ip
Purpose of review: Crohn's disease is a relapsing inflammatory condition and disease recurrence after surgery is common. Significant variation in clinical practice remains despite progress in management of postoperative C...
Biologics, small molecule therapies and surgery in small bowel Crohn's disease [0.03%]
小肠克罗恩病的生物制剂、小分子疗法和手术治疗
Joshua M Steinberg,Reezwana Chowdhury,Sowmya Sharma et al.
Joshua M Steinberg et al.
Purpose of review: The terminal ileum and small bowel (SB) are involved in 30-45% of patients with Crohn's disease, while 20% have both small and large bowel involvement. Ileal Crohn's is associated with higher risk of pr...