Dawn M E Bowdish,Candice Quin
Dawn M E Bowdish
Purpose of review: It has been known that the cytokine TNF (tumor necrosis factor alpha) influences hematopoiesis for decades. We now know that increases in TNF in the aging microenvironment favor the persistence and expa...
YY1 in hematopoietic stem cells: epigenetic regulation, chromatin architecture, and aging [0.03%]
造血干细胞中的YY1：表观遗传调控、染色质结构和衰老
Yinghua Wang,Xuan Pan
Yinghua Wang
Purpose of review: Yin Yang 1 (YY1) is a multifunctional transcription factor (TF) with established roles in lymphocyte development. More recently, its functions as a Polycomb group (PcG) protein and chromatin structural ...
Sen Zhang,Sandra Pinho
Sen Zhang
Purpose of review: Recent studies have expanded the concept of the bone marrow niche beyond stromal cells to include differentiated hematopoietic progeny as direct regulators of hematopoietic stem cells (HSCs). Among thes...
From bud to stem: dynamics of hematopoietic stem cells that drive homing and mobilization [0.03%]
从芽到干：调控归巢与动员的造血干细胞动力学
Farnaz Razmkhah,Stephanie N Hurwitz
Farnaz Razmkhah
Purpose of review: Hematopoietic stem and progenitor cells (HSPCs) ensure lifelong hematopoiesis through their unique ability to self-renew and differentiate into all blood cell lineages. Their localization within bone ma...
BEACH domain-containing proteins: emerging roles in hematopoiesis and immune homeostasis [0.03%]
含BEACH结构域的蛋白质：其在造血和免疫稳态中的作用不容小觑
Abigail Hateley,Miguel Ganuza
Abigail Hateley
Purpose of review: BEACH-domain-containing proteins (BDCPs) are large scaffolding proteins that regulate vesicle trafficking, autophagy, and granule biogenesis. This review synthesizes recent mechanistic and clinical adva...
Anna Konturek-Ciesla,David Bryder
Anna Konturek-Ciesla
Purpose of review: Aging is associated with impaired B lymphopoiesis and T lymphopoiesis, contributing to immunosenescence and poor immune recovery. Although this decline can be attributed to intrinsic hematopoietic stem ...
The interface of hemostasis and inflammation: endothelial-platelet dynamics in thrombosis [0.03%]
止血与炎症的界面：血栓形成中的内皮细胞-血小板动力学关系
Siobhan Branfield
Siobhan Branfield
Purpose of review: This review summarizes current understanding of platelet-endothelial contributions to thrombosis, emphasizing molecular crosstalk [von Willebrand factor (VWF)/ADAMTS13 balance, P-selectin, platelet glyc...
Endothelial barrier disruption and contact system modulation during bacterial infection [0.03%]
细菌感染期间的内皮屏障破坏和接触系统调节
Dillon J Bohinc,Sara Zalghout
Dillon J Bohinc
Purpose of review: This review examines how bacterial pathogens disrupt vascular barrier integrity and manipulate coagulation with a focus on endothelial signaling pathways, bacterial effectors, and contextual determinant...
The multifaceted role of platelets in systemic sclerosis: beyond haemostasis! [0.03%]
血小板在系统性硬化病中多方面的角色：超出止血！
Veronica Batani,Aslıhan Avanoglu Guler,Jelena Colic
Veronica Batani
Purpose of review: Systemic sclerosis (SSc) is characterized by early and persistent vascular injury, immune dysregulation, and fibrosis, with a growing recognition of an excess thrombotic burden that cannot be fully expl...
Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-CoV-2 infection [0.03%]
携带补体的胞外囊泡在SARS-CoV-2感染中的作用：凝血障碍的“信使”
Apostolos Taxiarchis,Iva Pruner
Apostolos Taxiarchis
Purpose of review: SARS-CoV-2 disease (COVID-19) is increasingly recognized as a thromboinflammatory vascular disorder characterized by dysregulated complement activation, endothelial injury, and sustained hypercoagulabil...