Inflammation as a pleiotropic regulator of megakaryocyte and platelet hemostatic, immune, and metabolic function [0.03%]
炎症作为多效性调节因子调节巨核细胞和血小板的止血、免疫和代谢功能
Guadalupe Rojas-Sanchez,Pavel Davizon-Castillo
Guadalupe Rojas-Sanchez
Purpose of review: During infectious and noninfectious inflammatory diseases, disruption of the immune-hemostatic balance increases both thrombotic and hemorrhagic risk. We propose that this bidirectional dysregulation re...
Augmenting immune reconstitution after adult allo-haematopoietic stem cell transplantation: current developments and modifiable determinants [0.03%]
allo-HSCT后成人免疫重建的增强：当前进展和可改变因素
Sebastian J Grocott,Igor Novitzky-Basso
Sebastian J Grocott
Purpose of review: Immune reconstitution after adult allogeneic haematopoietic stem cell transplantation (allo-HSCT) shapes infection risk, vaccine responsiveness, relapse and nonrelapse mortality. Advances in graft-vs.-h...
Dynamic myeloid suppressor states in cancer and inflammation and their therapeutic potential [0.03%]
癌症和炎症中的动态髓系抑制状态及其治疗潜力
Alexandra Pommier,Jose A Cancelas
Alexandra Pommier
Purpose of review: Myeloid-derived suppressor cells (MDSCs) are central mediators of immune dysregulation in cancer, infection, and inflammatory diseases. This review highlights recent advances redefining MDSCs' biology, ...
Factor XIa inhibition for the prevention of thrombosis: mechanism, clinical trial signals, and indication-specific positioning [0.03%]
因子XIa抑制在血栓预防中的作用：机制、临床试验信号及特定适应症定位
Evan Kidder,Nirav Dhanesha
Evan Kidder
Purpose of review: Factor XI (FXI) and its activated form, factor XIa (FXIa), have emerged as a leading novel anticoagulant target of the past decade. This review summarizes mechanistic and clinical data from 2023 through...
Nutrition as a regulator of hematopoietic stem cell biology and transplantation [0.03%]
营养在造血干细胞生物学和移植中的调控作用
Sophia Shi,Ying Liang
Sophia Shi
Purpose of review: Nutrition is increasingly recognized as a biologically active regulator of hematopoietic stem cell (HSC) function and transplant recovery. This review summarizes recent advances linking nutrient availab...
From biomimicry to clinical actionability: rethinking high-shear thrombosis as a mechanobiological system [0.03%]
从仿生学到临床应用：重新思考高剪切血栓形成作为机械生物学系统
Marcus Vinicius Batista da Silva,Christopher A Bresette,Viviana Clavería
Marcus Vinicius Batista da Silva
Purpose of review: Arterial thrombosis remains a leading cause of morbidity and mortality worldwide, while its mechanistic understanding and clinical management remain limited. In this review, we discuss how recent advanc...
Bidirectional relationship between metabolic and thrombotic disease mechanisms [0.03%]
代谢与血栓疾病机制之间的双向关系
Angelica T Jameson,Woosuk S Hur
Angelica T Jameson
Purpose of review: Metabolic diseases, including obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and diabetes, are associated with increased thrombotic risks. Conversely, components of the hemos...
The dual role of the brain-derived neurotrophic factor as a regulator of hemostasis and thrombotic risk [0.03%]
脑源性神经营养因子在止血和血栓风险调节中的双重作用
Charlotte Aubin,Jessica Blais,Yanitsa Petkova et al.
Charlotte Aubin et al.
Purpose of review: Brain-derived neurotrophic factor (BDNF), a neurotrophin associated with neuronal survival and plasticity, has emerged as a significant player in cardiovascular biology. This review examines the evidenc...
Molly Brakhane,Abigail Ajanel,Joshua I Siner
Molly Brakhane
Purpose of review: The purpose of this review is to describe the activity and function megakaryocytes and platelets in the myeloproliferative neoplasms (MPNs.) Specific attention is paid to how megakaryocytes relate to di...