Xenotransplantation and the organ shortage: evaluating policy priorities [0.03%]
异体器官移植与供体短缺：评估政策优先级
Jessica S Kopew,Jarrod Bailey,Catharine E Krebs
Jessica S Kopew
Purpose of review: Xenotransplantation has emerged as a popular potential solution for increasing organ supply, but it comes with formidable public health risks and ethical harms. The purpose of this review is to evaluate...
Ali B Abbasi,Babak J Orandi
Ali B Abbasi
Purpose of review: Nearly half of all patients listed for kidney transplant now have obesity, which is associated with increased rates of perioperative complications and graft loss. Here, we provide an update on the manag...
Evidence-based prehabilitation and rehabilitation in solid organ transplantation: current insights and clinical research priorities [0.03%]
基于证据的器官移植术前康复与术后康复：当前研究见解及临床研究重点
Juliet Briggs,Siobhán Freeman,Sharlene Greenwood
Juliet Briggs
Purpose of review: Rehabilitation before (prehabilitation) and after solid organ transplantation is gaining increasing interest as an important aspect of holistic treatment. Despite guidelines recommending clinical implem...
Chiara Lazzeri,Adriano Peris
Chiara Lazzeri
Purpose of review: The integration of artificial intelligence into allocation, organ retrieval and transplantation processes represents an innovative approach to address these challenges and enhance the efficiency and eff...
Sara Fovargue
Sara Fovargue
Purpose of review: Across the world, several solid organ xenotransplants have been reported as being provided to deceased people and to living patients. In the United States, xenotransplants to living patients have been a...
Expansion of molecular mismatch scores to guide clinical management of kidney transplant patients [0.03%]
扩展分子不匹配评分以指导肾移植患者的临床管理
Emmett Tsz Yeung Wong,Chris Wiebe
Emmett Tsz Yeung Wong
Purpose of review: Optimizing outcomes for kidney transplant recipients requires both minimizing premature death related to over-immunosuppression and avoiding alloimmune injury associated with under-immunosuppression. Bo...
Pathologic findings in preclinical and early clinical kidney xenotransplantation [0.03%]
前期和早期临床肾异种移植的病理发现
Ivy A Rosales,Claire Trivin-Avillach
Ivy A Rosales
Purpose of review: After many decades of experimental studies and the advent of genetic engineering for pig organs, xenotransplantation has finally reached clinical application. Clinical trials are beginning, and a review...
Clinical translation of xenotransplantation: regulatory pathways and ethical oversight in a global context [0.03%]
异种移植的临床转化：全球范围内的监管途径和伦理监督
Brendan Parent,Benjamin Hippen
Brendan Parent
Purpose of review: The science and practice of xenotransplantation is advancing more rapidly than the regulatory infrastructure that will be necessary to ensure the promise of alleviating the organ shortage can be safely ...
L Syd M Johnson,Abbie D Leino,D Brian Haver
L Syd M Johnson
Purpose of review: Xenotransplantation is closer to clinical reality than ever, with planned clinical trials in development. Enrolling participants in these trials may be difficult without an understanding of patient and ...