The present and future of nonviral delivery-based genome editing for hereditary hearing loss [0.03%]
基于非病毒递送的基因编辑技术在遗传性听力损失中的现状和未来展望
Seung Hyun Jang,Heon Yung Gee,Jinsei Jung
Seung Hyun Jang
Purpose of review: This review summarizes nonviral genome-editing delivery platforms for hereditary hearing loss, focusing on lipid nanoparticles (LNPs) and engineered virus-like particles (eVLPs), and discusses their adv...
Saangyoung E Lee,Margaret T Dillon,Kevin D Brown
Saangyoung E Lee
Purpose of review: Frequency-to-place mismatch is the discrepancy between the frequency information delivered by a cochlear implant electrode and the natural cochlear place frequency location that is stimulated. Frequency...
Optical coherence tomography of the tympanic membrane and middle ear: clinical applications [0.03%]
光学相干断层扫描技术在鼓膜及中耳的临床应用
Julien B Azimzadeh,Brian E Applegate,John S Oghalai
Julien B Azimzadeh
Purpose of review: Optical coherence tomography (OCT) is a noninvasive optical imaging technique to image soft tissue and thin bony structures with high resolution, approaching that of histology. This review summarizes re...
Photon-counting detector computed tomography for temporal bone: does higher resolution matter? [0.03%]
高分辨率对颞骨光子计数探测器CT成像有用吗？
Madison V Epperson,Shuai Leng,John I Lane et al.
Madison V Epperson et al.
Purpose of review: Photon-counting detector computed tomography (PCD-CT) represents a major technological advancement in computed tomography, offering improved spatial resolution, reduced image noise, and increased dose e...
Adam Omari,Andreas Frithioff,Steven Arild Wuyts Andersen
Adam Omari
Purpose of review: Temporal bone surgery requires high precision drilling near critical anatomical structures. Traditional planning relies on expertise and the mental reconstruction of 2D imaging, which is cognitively dem...
Graduated autonomy in head and neck microvascular surgery fellowship training: oncologic and reconstructive competency, safety, and educational implications [0.03%]
头颈显微外科专科培训中自主权分阶段授予的现状、安全性和教育影响：肿瘤和重建胜任力的影响
Kelly L Staricha,Joshua D Smith,Steven B Chinn et al.
Kelly L Staricha et al.
Purpose of review: Graduated autonomy is a foundational principle of surgical education, yet no standardized framework exists for how autonomy should be structured, assessed, or achieved within head and neck oncologic and...
Costs and system-wide considerations within head and neck reconstruction: moving toward a value-based care framework [0.03%]
头颈重建中的成本和系统性考量：迈向基于价值的护理框架
Mitchell Mead,Pratyusha Yalamanchi
Mitchell Mead
Purpose of review: Head and neck (H&N) reconstruction presents unique economic and system-wide considerations due to the resource-intensive nature of reconstructive techniques, such as free flap reconstruction and multidi...
Beatrice C Go,Roy Xiao,Yong Ju Jang
Beatrice C Go
Purpose of review: Dorsal augmentation rhinoplasty is a technically demanding procedure that requires careful selection of grafting materials and techniques to achieve durable and aesthetically pleasing results. This revi...
Jonathan M Bernstein,Margaret M Coffey,Simon H Wood
Jonathan M Bernstein
Purpose of review: Six systematic reviews and meta-analyses (2019-2025) have compared reconstructive options for circumferential pharyngeal defects following total laryngopharyngectomy. This narrative review synthesises t...
Emma Ho,Joseph Latif,Catherine Meller
Emma Ho
Purpose of review: Facial scarring represents a significant clinical and psychosocial burden for patients. This review summarizes current evidence for prophylactic and therapeutic scar management techniques relevant to ea...