Understanding idiopathic hypersomnia: diagnosis, pathophysiology, and management [0.03%]
认识特发性过度嗜睡综合征：诊断、发病机制及治疗管理
Madeeha Shahzadi,Renee Monderer,Michael J Thorpy
Madeeha Shahzadi
Purpose of review: Idiopathic hypersomnia is a chronic and often disabling sleep disorder characterized by excessive daytime sleepiness despite adequate or prolonged nighttime sleep. With recent advances in diagnosis and ...
Amjad Horani,Wallace Wee,Heymut Omran et al.
Amjad Horani et al.
Purpose of review: Primary ciliary dyskinesia is a rare, inherited disease, and over 60 genes have been linked to motile ciliopathies. During the past quarter century, our understanding of the complex genetics and biologi...
Challenges and opportunities for drug development in rare pulmonary diseases like cystic fibrosis: an industry perspective [0.03%]
罕见肺病（如囊性纤维化）药物研发的挑战与机遇——来自产业界的观点
Zachary M Sellers,Alan H Cohen
Zachary M Sellers
Purpose of review: There is a critical need for new therapies addressing the high unmet needs of individuals with rare lung diseases. This review examines the challenges industry sponsors face in developing therapeutic pr...
Primary ciliary dyskinesia: clinical manifestations and current diagnostic approaches [0.03%]
原发纤毛运动不良的临床表现及目前诊断方法
Robert J Reklow,Madison J Weir,Sharon D Dell
Robert J Reklow
Purpose of review: This review summarizes the clinical symptoms of primary ciliary dyskinesia (PCD) beginning at birth and current approaches for confirming diagnosis. Strengths and limitations of innovative adjunctive te...
New anti-infective approaches to treat airway infections in persons with cystic fibrosis and bronchiectasis [0.03%]
治疗囊性纤维化和支气管扩张患者呼吸道感染的新抗菌方法
Justin Massey,Ghady Haidar,Ryan K Shields et al.
Justin Massey et al.
Purpose of review: Cystic fibrosis (CF) and non-CF bronchiectasis can predispose patients to airway infections that are difficult to treat. The purpose of this review is to discuss recently developed anti-infectives which...
James Tolle,Michael O&#x;Connor
James Tolle
Purpose of review: There is a significant overlap between the diagnostic evaluation for adult and pediatric patients with bronchiectasis; however, also important age-specific unique considerations. This review focuses on ...
Obstructive sleep apnea and the gut microbiota - mechanisms and opportunities [0.03%]
阻塞性睡眠呼吸暂停与肠道微生态：机制和干预策略
Joe Alcock
Joe Alcock
Purpose of review: The relationship between obstructive sleep apnea (OSA) and the gut microbiota is increasingly recognized, yet the involvement of specific microbial taxa and the direction of causality remain unclear. Th...
Obstructive sleep apnea in pregnancy: emerging insights into maternal and fetal outcomes [0.03%]
妊娠期阻塞性睡眠呼吸暂停：母胎结局的新认识
Sohaib Ansari,Vesna Buntak,Ghada Bourjeily
Sohaib Ansari
Purpose of review: Sleep disordered breathing (SDB) encompasses a spectrum of disorders ranging from snoring to complete upper airway collapse and cessation of respiration leading to oxygen desaturation and sleep fragment...
Isaac Martin,Felix Ratjen,Patrick Flume
Isaac Martin
Purpose of review: The advent of CFTR modulators and the adoption of telemedicine during the COVID-19 pandemic have prompted reconsideration of cystic fibrosis (CF) care models. This review explores how care delivery may ...
Glucagon-like peptide-1 receptor agonists for the treatment of obstructive sleep apnea [0.03%]
胰高糖素样肽-1受体激动剂治疗阻塞性睡眠呼吸暂停综合征
Danielle A D&#x;Annibale,Mizuho Mimoto,Karen C McCowen et al.
Danielle A D&#x;Annibale et al.
Purpose of review: This review highlights the emerging data on the use of incretin therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RA) and dual GLP-1RA and glucose-dependent insulinotropic peptide (GI...