Meeting review: Bioinformatics of biochips: accelerating discovery in functional genomics [0.03%]
生物芯片的生物信息学：加速功能基因组学中的发现研讨会综述
Douglas Roy,Thorsten Forster,Sean McGeever et al.
Douglas Roy et al.
The use of microarray technology for the analysis of Streptococcus pneumoniae [0.03%]
基因芯片技术在肺炎链球菌分析中的应用研究进展
Jackie McCluskey,Christopher G Dowson,Timothy J Mitchell
Jackie McCluskey
Streptococcus pneumoniae is an important human pathogen associated with pneumonia, septicaemia, meningitis and otitis media. It is estimated to result in over 3 million child deaths worldwide every year and an even greater number of deaths ...
Separated at birth? Microarray analysis of two strikingly similar yersinia species [0.03%]
芯片分析两种极其相似的耶尔森氏菌物种
S J Hinchliffe,K E Isherwood,R A Stabler et al.
S J Hinchliffe et al.
The heat shock response of Mycobacterium tuberculosis: linking gene expression, immunology and pathogenesis [0.03%]
结核分枝杆菌的热休克反应：基因表达、免疫学及致病性的联系
Graham R Stewart,Lorenz Wernisch,Richard Stabler et al.
Graham R Stewart et al.
The regulation of heat shock protein (HSP) expression is critically important to pathogens such as Mycobacterium tuberculosis and dysregulation of the heat shock response results in increased immune recognition of the bacterium and reduced ...
Microarray analysis of bacterial gene expression: towards the regulome [0.03%]
细菌基因表达的微阵列分析：通向调控组学之路
Sharon L Kendall,Farahnaz Movahedzadeh,Andreas Wietzorrek et al.
Sharon L Kendall et al.
Microarray technology allows co-regulated genes to be identified. In order to identify genes that are controlled by specific regulators, gene expression can be compared in mutant and wild-type bacteria. However, there are a number of pitfal...
The curse of normalization [0.03%]
常态化的诅咒
Olaf Wolkenhauer,Carla Möller-Levet,Fatima Sanchez-Cabo
Olaf Wolkenhauer
Despite its enormous promise to further our understanding of cellular processes involved in the regulation of gene expression, microarray technology generates data for which statistical pre-processing has become a necessity before any inter...
Microarrays for public health: genomic epidemiology of tuberculosis [0.03%]
结核病的基因组流行病学研究——微数组技术在公共健康中的应用
Jamila Shafi,Peter W Andrew,Michael R Barer
Jamila Shafi
In response to a large local school-based outbreak of tuberculosis, we have been evaluating the utility of microarray bacterial genomic analysis in outbreak management. After initial comparison of the isolate from the index case with Mycoba...
In vitro gene expression dissected: chemostat surgery for mycobacterium tuberculosis [0.03%]
结核分枝杆菌恒化器培养的基因表达分析研究
Brian W James,Joanna Bacon,Tobias Hampshire et al.
Brian W James et al.
A unique approach, combining defined and reproducible in vitro models with DNA microarrays, has been developed to study environmental modulation of mycobacterial gene expression. The gene expression profiles of samples of Mycobacterium tube...
Tahir R Ali,J Simon Kroll,Paul R Langford
Tahir R Ali
In 1995 the genome sequence of the Haemophilus influenzae KW20 (Rd) strain was published, the first available for a free-living organism. The genome has been invaluable in global strategies to identify certain virulence-related genes, e.g. ...
Brendan W Wren
Brendan W Wren