Molecular diversity of the antimicrobial domain of beta-defensin 3 and homologous peptides [0.03%]
β-防御素3抗菌结构域及其同源肽的分子多样性研究
Gerardo M Nava,Magdalena Escorcia,M Pilar Castañeda
Gerardo M Nava
Human beta-defensin 3 has received great interest for possible pharmaceutical applications. To characterize the biology of this antimicrobial peptide, the mouse beta-defensin 14 has been selected as a prototypical model. This report provide...
An exon-based comparative variant analysis pipeline to study the scale and role of frameshift and nonsense mutation in the human-chimpanzee divergence [0.03%]
一个基于外显子的比较变异分析管线用于研究人类-黑猩猩分歧过程中的框移和无义突变的规模及作用
GongXin Yu
GongXin Yu
Chimpanzees and humans are closely related but differ in many deadly human diseases and other characteristics in physiology, anatomy, and pathology. In spite of decades of extensive research, crucial questions about the molecular mechanisms...
Physiological function of mycobacterial mtFabD, an essential malonyl-CoA:AcpM transacylase of type 2 fatty acid synthase FASII, in yeast mct1Delta cells [0.03%]
结核菌mtFabD的生理功能是一种新型脂肪酸合成酶FAS II中的一种必要的丙酮酸辅酶A转移酶，在酵母mct1delta细胞中的作用
Aner Gurvitz
Aner Gurvitz
Mycobacterium tuberculosis mtFabD is an essential malonyl-CoA:AcpM transacylase and is important for vital protein-protein interactions within type 2 fatty acid synthase FASII. mtFabD contacts KasA, KasB, FabH, InhA, and possibly also HadAB...
Characterization of the gene BmEm4, a homologue of Drosophila E(spl)m4, from the silkworm, Bombyx mori [0.03%]
家蚕Bombyx mori BmEm4基因的克隆、表达及功能初步分析
Fenghui Zeng,Hongxia Xie,Zuoming Nie et al.
Fenghui Zeng et al.
The Drosophila E(spl)m4 gene contains some highly conserved motifs (such as the Brd box, GY box, K box, and CAAC motif) in its 3' untranslated region (3' UTR). It was shown to be a microRNA target gene in Drosophila and to play an important...
Reverse genetics for functional genomics of phytopathogenic fungi and oomycetes [0.03%]
用于植物病原真菌和卵菌功能基因组学的反向遗传学
Vijai Bhadauria,Sabine Banniza,Yangdou Wei et al.
Vijai Bhadauria et al.
Sequencing of over 40 fungal and oomycete genomes has been completed. The next major challenge in modern fungal/oomycete biology is now to translate this plethora of genome sequence information into biological functions. Reverse genetics ha...
K Anamika,K R Abhinandan,K Deshmukh et al.
K Anamika et al.
Protein Kinase-Like Non-kinases (PKLNKs), which are closely related to protein kinases, lack the crucial catalytic aspartate in the catalytic loop, and hence cannot function as protein kinase, have been analysed. Using various sensitive seq...
Xiqiang Liu,Zugen Chen,Jinsheng Yu et al.
Xiqiang Liu et al.
Head and neck/oral cancer (HNOC) is a devastating disease. Despite advances in diagnosis and treatment, mortality rates have not improved significantly over the past three decades. Improvement in patient survival requires a better understan...
Analysis of array-CGH data using the R and Bioconductor software suite [0.03%]
使用R和Bioconductor软件套件分析阵列CGH数据
Winfried A Hofmann,Anja Weigmann,Marcel Tauscher et al.
Winfried A Hofmann et al.
Background: Array-based comparative genomic hybridization (array-CGH) is an emerging high-resolution and high-throughput molecular genetic technique that allows genome-wide screening for chromosome alterations. DNA copy n...
Anaplasma phagocytophilum and Anaplasma marginale elicit different gene expression responses in cultured tick cells [0.03%]
Anataxa phagocytophilum 和 Anataxa marginale 在培养的蜱细胞中诱导不同的基因表达反应
Zorica Zivkovic,Edmour F Blouin,Raúl Manzano-Roman et al.
Zorica Zivkovic et al.
The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes obligate tick-transmitted intracellular organisms, Anaplasma phagocytophilum and Anaplasma marginale that multiply in both vertebrate and tick host cells. Recently, we showed tha...
Alternative splicing of transcription factors' genes: beyond the increase of proteome diversity [0.03%]
转录因子基因的可变剪接：超越蛋白质组多样性增加的作用
David Talavera,Modesto Orozco,Xavier de la Cruz
David Talavera
Functional modification of transcription regulators may lead to developmental changes and phenotypical differences between species. In this work, we study the influence of alternative splicing on transcription factors in human and mouse. Ou...