Illustrating an Adaptive Prespecification Framework for Observational Research: Target Trial Emulations Comparing Immunomodulator Treatments for COVID-19 [0.03%]
适应性预规范框架在观察性研究中的图解说明：针对比较免疫调节药物治疗COVID-19的靶标试验模拟
Andrew R Weckstein,Vera Frajzyngier,Sarah E Vititoe et al.
Andrew R Weckstein et al.
Rigid prespecification can be impractical for noninterventional studies using secondary datasets, where data-driven flexibility is often required. Using target trial emulations comparing immunomodulator treatments for COVID-19, we piloted a...
OpenSAFELY: Effectiveness of COVID-19 vaccination in children and adolescents [0.03%]
儿童和青少年的COVID-19疫苗接种效果的开放安全性研究（OpenSAFELY）
Colm D Andrews,Edward P K Parker,Elsie Horne et al.
Colm D Andrews et al.
Background: We assessed the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination, offered as part of the national COVID-19 vaccine roll-out from September 2021, in children and adolescents in En...
Pregnancy Length Measurement Error: A comparison of Last Menstrual Period and Ultrasonography with Ovulation-Based Estimation [0.03%]
末次月经与超声波孕囊或卵黄囊法测定孕龄的误差比较
Ginna L Doss,Julie L Daniels,Sunni L Mumford et al.
Ginna L Doss et al.
Background: Last menstrual period (LMP) and ultrasound are commonly used to estimate pregnancy length. Ovulation, which precedes fertilization by ≤24 hours, should give a more accurate estimate. ...
Erratum: Definition and Interpretation of Separable Path-specific Effects With Multiple Ordered Mediators [0.03%]
订正：多重有序介导变量的可分路径特定效应的定义与解释
Yan-Lin Chen,Sheng-Hsuan Lin
Yan-Lin Chen
Rachael K Ross,Matthew P Fox,Catherine R Lesko et al.
Rachael K Ross et al.
Measurement error is ubiquitous in the data used for epidemiologic research and can lead to meaningful information bias. Analytic approaches to address measurement error and quantitative bias analyses examining the potential impact of measu...
Use of routinely collected data to classify planned mode of delivery among pregnancies with a previous cesarean delivery: a validation study [0.03%]
利用常规收集的数据对既往有剖宫产史的妊娠计划分娩方式进行分类的一项验证研究
Mary M Brown,Ya-Hui Yu,Jennifer A Hutcheon et al.
Mary M Brown et al.
Background: Counseling on the harms and benefits of a planned vaginal versus a planned repeat cesarean delivery often relies on observational studies using routinely collected (or administrative) data. However, the accura...
Comparative risks of opioid overdose in patients on oxycodone initiating selective serotonin reuptake inhibitors [0.03%]
阿片类药物戒断接受选择性5-羟色胺再摄取抑制剂治疗的氧可酮患者的风险比较
Katsiaryna Bykov,C Andrew Basham,Nazleen F Khan et al.
Katsiaryna Bykov et al.
Background: Selective-serotonin reuptake inhibitors (SSRIs) are often co-prescribed with oxycodone, yet may potentiate respiratory depression. We aimed to assess the comparative effects of SSRIs on opioid overdose when ad...
Carl Bonander,Marta Blangiardo,Ulf Strömberg
Carl Bonander
Bayesian disease-mapping models are widely used in small-area epidemiology to account for spatial correlation and stabilize estimates through spatial smoothing. In contrast, difference-in-differences (DID) methods-commonly used to estimate ...
Sensitivity of cancer registry linkage with missing or incomplete social security number and implications for cancer cohorts [0.03%]
缺失或不完整的社会保障号的癌症登记链接的敏感性及其对癌症队列的影响
Lauren E McCullough,Anusila Deka,Christina Newton et al.
Lauren E McCullough et al.
Background: Linking cancer cohort participants to state cancer registries typically relies on personally identifiable information, including Social Security Numbers (SSN), which uniquely identify individuals. However, com...
Doubly Robust Control Outcome Calibration Approach Estimation of Conditional Effects with Uncontrolled Confounding [0.03%]
具有未控制混杂因素的条件效应的双重稳健控制结果校准方法估计
Wen Wei Loh
Wen Wei Loh
Drawing causal conclusions about nonrandomized exposures rests on assuming no uncontrolled confounding, but it is rarely justifiable to rule out all putative violations of this routinely made yet empirically untestable assumption. Alternati...