Unbiased estimates using temporally aggregated outcome data in time series analysis: generalization to different outcomes, exposures and types of aggregation [0.03%]
时间序列分析中使用不同结果、暴露和聚合类型的暂态聚集结果数据进行无偏估计的推广研究
Xavier Basagaña,Joan Ballester
Xavier Basagaña
Background: A new method for time series analysis was recently formulated and implemented that uses temporally aggregated outcome data to generate unbiased estimates of the underlying association between temporally disagg...
Causal mediation analysis with mediator-outcome confounders affected by exposure - on definition and identification of generalized natural indirect effect [0.03%]
暴露影响中介变量与结局相关混杂因素的因果中介分析——关于广义自然间接效应的定义及识别问题研究
Yan-Lin Chen,Tsung Yu,Sheng-Hsuan Lin
Yan-Lin Chen
Causal mediation analysis aims to disentangle the pathways through which an exposure influences an outcome. In the presence of mediator-outcome confounders affected by exposure (intermediate confounders), the natural indirect effect (NIE) i...
Does Delayed Response Due to Busy Ambulances Impact Risk of Death and Hospital Service Use?: A Cohort Study of 240,000 Medical Emergencies [0.03%]
救护车忙是否会影响延迟救治及死亡风险：一项针对24万医疗急救的队列研究
Andreas Asheim,Lars Eide Næss,Andreas Krüger et al.
Andreas Asheim et al.
Objectives: When ground ambulances are busy with any task, delays are likely for concurrent emergencies. Whereas time-critical conditions are affected by delays, general impacts remain unclear. We aimed to assess how dela...
Illustrating an Adaptive Prespecification Framework for Observational Research: Target Trial Emulations Comparing Immunomodulator Treatments for COVID-19 [0.03%]
适应性预规范框架在观察性研究中的图解说明：针对比较免疫调节药物治疗COVID-19的靶标试验模拟
Andrew R Weckstein,Vera Frajzyngier,Sarah E Vititoe et al.
Andrew R Weckstein et al.
Rigid prespecification can be impractical for noninterventional studies using secondary datasets, where data-driven flexibility is often required. Using target trial emulations comparing immunomodulator treatments for COVID-19, we piloted a...
OpenSAFELY: Effectiveness of COVID-19 vaccination in children and adolescents [0.03%]
儿童和青少年的COVID-19疫苗接种效果的开放安全性研究（OpenSAFELY）
Colm D Andrews,Edward P K Parker,Elsie Horne et al.
Colm D Andrews et al.
Background: We assessed the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination, offered as part of the national COVID-19 vaccine roll-out from September 2021, in children and adolescents in En...
Pregnancy Length Measurement Error: A comparison of Last Menstrual Period and Ultrasonography with Ovulation-Based Estimation [0.03%]
末次月经与超声波孕囊或卵黄囊法测定孕龄的误差比较
Ginna L Doss,Julie L Daniels,Sunni L Mumford et al.
Ginna L Doss et al.
Background: Last menstrual period (LMP) and ultrasound are commonly used to estimate pregnancy length. Ovulation, which precedes fertilization by ≤24 hours, should give a more accurate estimate. ...
Erratum: Definition and Interpretation of Separable Path-specific Effects With Multiple Ordered Mediators [0.03%]
订正：多重有序介导变量的可分路径特定效应的定义与解释
Yan-Lin Chen,Sheng-Hsuan Lin
Yan-Lin Chen
Rachael K Ross,Matthew P Fox,Catherine R Lesko et al.
Rachael K Ross et al.
Measurement error is ubiquitous in the data used for epidemiologic research and can lead to meaningful information bias. Analytic approaches to address measurement error and quantitative bias analyses examining the potential impact of measu...
Use of routinely collected data to classify planned mode of delivery among pregnancies with a previous cesarean delivery: a validation study [0.03%]
利用常规收集的数据对既往有剖宫产史的妊娠计划分娩方式进行分类的一项验证研究
Mary M Brown,Ya-Hui Yu,Jennifer A Hutcheon et al.
Mary M Brown et al.
Background: Counseling on the harms and benefits of a planned vaginal versus a planned repeat cesarean delivery often relies on observational studies using routinely collected (or administrative) data. However, the accura...
Comparative risks of opioid overdose in patients on oxycodone initiating selective serotonin reuptake inhibitors [0.03%]
阿片类药物戒断接受选择性5-羟色胺再摄取抑制剂治疗的氧可酮患者的风险比较
Katsiaryna Bykov,C Andrew Basham,Nazleen F Khan et al.
Katsiaryna Bykov et al.
Background: Selective-serotonin reuptake inhibitors (SSRIs) are often co-prescribed with oxycodone, yet may potentiate respiratory depression. We aimed to assess the comparative effects of SSRIs on opioid overdose when ad...