Real World Data of Viral Suppression With Darunavir/Cobicistat and Dolutegravir/Rilpivirine Among Treatment-Experienced Patients Living With Multidrug-Resistant HIV [0.03%]
用于治疗经多药治疗失败的HIV患者的 darunavir/cobicistat和dolutegravir/rilpivirine的真实世界病毒抑制数据
Preethi S Samuel,Folake Olaleye,Maria Longo et al.
Preethi S Samuel et al.
Background: Despite the effectiveness of the TRIO regimen in maintaining viral suppression, as seen in the ANRS 139 TRIO trial, one drawback is the high pill burden. However, with the development of newer antiretrovirals, this regimen can b...
Comparison of Safety and Treatment Continuity of Palbociclib and Abemaciclib for Hormone Receptor-Positive, HER2-Negative Metastatic/Recurrent Breast Cancer [0.03%]
帕博西尼与阿贝西林治疗激素受体阳性、HER2阴性的转移性/复发性乳腺癌的安全性及连续给药情况的比较研究
Makiko Go,Michio Kimura,Shiori Yamada et al.
Makiko Go et al.
Background: Appropriate adverse event (AE) management and maintenance of therapeutic intensity are necessary to achieve therapeutic benefits of CDK4/6 inhibitors (palbociclib and abemaciclib) in hormone receptor-positive, HER2-negative meta...
Comparative Safety and Effectiveness of Urea and Tolvaptan for the Management of Hyponatremia [0.03%]
尿素和托伐普坦治疗低钠血症的比较安全性和有效性
Paolo A Scalla,Stephanie M Palma,Erika Dittmar et al.
Paolo A Scalla et al.
Background: The optimal management of euvolemic and hypervolemic hyponatremia remains controversial. The effectiveness of the vasopressin receptor antagonist tolvaptan on serum sodium normalization has been well described in the literature,...
Real-World Performance Benchmarks in the Reading Ability of Prescription Drug Labels by Community-Dwelling Older Adults [0.03%]
社区老年人阅读药品说明书的能力的真实世界表现评测
Ryan Hakim,Matthew Li,Martin Gorbien et al.
Ryan Hakim et al.
Background: Despite known recommendations regarding standards for print size and the intuitive importance of vision in reading prescription labels, the predictive nature of vision and prescription label readability remain...
Impact of American Diabetes Association 2022 Guidelines on Prescribing Rates of Sodium-Glucose Cotransporter-2 Inhibitors in Ambulatory Care Organization Patients With Type 2 Diabetes [0.03%]
美国糖尿病协会2022年指南对 ambulatory care organization 中2型糖尿病患者钠-葡萄糖共转运蛋白-2抑制剂处方率的影响
Alexis R Bogannam,Ewan McNicol,Kevin DeLeonardo et al.
Alexis R Bogannam et al.
Background: Recent clinical trials and guideline updates have highlighted the efficacy and safety of sodium-glucose cotransporter-2 inhibitor (SGLT2i) use in patients with type 2 diabetes (T2D) and comorbidities including atherosclerotic ca...
Impact of Outpatient Beta Blocker Therapy Adjustment on Tachyarrhythmias in Patients With Heart Failure With Reduced Ejection Fraction Admitted for Acute Decompensated Heart Failure [0.03%]
心功能不全患者门诊β受体阻滞剂调整对急性失代偿性心力衰竭住院时快速型心律失常的影响
Ryan W Bok,Jordan L Lacoste,Wei Fang et al.
Ryan W Bok et al.
Background: Limited data exists to evaluate the optimal management of outpatient beta blocker therapy when patients with heart failure with reduced ejection fraction (HFrEF) are admitted for acute decompensated heart failure (ADHF). Objecti...
Take It Easy! Serotonin Syndrome Precipitated by the Rapid Titration of Sertraline and Trazodone in the Setting of Risperidone Use [0.03%]
慎用！利培酮治疗背景下米氮平及舍曲林快速增量引起血清素综合症
Julie Martino,Zane Elfessi,Katarzyna Szaflarska et al.
Julie Martino et al.
Serotonin syndrome is a potentially life-threatening condition caused by a toxic excess of serotonin leading to overstimulation of the nervous system. Because it is a diagnosis of exclusion, it can be underrecognized, making the true incide...
Pain Assessment Following Opioid Administration in Aneurysmal Subarachnoid Hemorrhage Associated Headache [0.03%]
与动脉瘤性蛛网膜下腔出血相关的头痛在阿片类药物治疗后的疼痛评估
Van T Bui,Carolyn Pfeifer,Dan K Snelgrove et al.
Van T Bui et al.
Background: Headache is a debilitating complication following an aneurysmal subarachnoid hemorrhage (aSAH). Despite its impact on morbidity and quality of life, limited evidence characterizes the effectiveness of opioids. Objective: The aim...
Emma L Klaserner,Kayla J Popova,Rikki-Leigh Gaudet
Emma L Klaserner
Venous thromboembolism (VTE), including both pulmonary embolism (PE) and deep vein thrombosis (DVT), is the leading cause of maternal death in developed countries. Pregnancy is associated with an increased risk of VTE due to physiologic cha...
CNS Aspergillosis and Cryptococcosis with Cytomegalovirus Pneumonia in a Patient with Chronic Lymphocytic Leukemia Treated with Acalabrutinib [0.03%]
慢性淋巴细胞白血病患者接受阿卡比替尼治疗后出现CNS曲霉菌和新型隐球菌感染伴巨细胞病毒感染肺炎病例报告
Taylor Fallin,Erica Thacker,Syeda Sahra et al.
Taylor Fallin et al.
Bruton's tyrosine kinase inhibitors (BTKis) are the preferred treatment for chronic lymphocytic leukemia (CLL). Despite their therapeutic benefits, these targeted agents have been associated with an increased risk of invasive infections. We...