Seizures Associated With High-Dose Cefazolin in a Patient With Renal Dysfunction: A Case Report [0.03%]
肾功能障碍患者使用大剂量头孢唑啉后出现癫痫发作的一例报告
Kulwant Kingra,Robert E Ariano,Aditya Sharma
Kulwant Kingra
Introduction and Objective: Cefazolin-induced encephalopathy and seizures are possibly related to excessive dosing; especially in those with renal dysfunction. This report aims to highlight the importance of dose adjustments of cefazolin in...
Single-Dose Gentamicin vs Standard Care for Treatment of Acute Uncomplicated Cystitis in Premenopausal Women: A Randomized Trial [0.03%]
单剂量庆大霉素vs标准治疗更年期前妇女急性单纯性膀胱炎：一项随机试验
Vincent Peyko,Jacob Sieger,Joseph Dombroski
Vincent Peyko
Background: Urinary tract infections (UTI) are a disease of serious impact on every country in the world. Growing resistance has decreased the efficacy of many antimicrobial options. Aminoglycosides, like gentamicin, have...
Methemoglobinemia in the Setting of Hemolysis: A Case Report Suggesting Reflex Lab for Patients with Oxygen Saturation Gap for Early Detection and Diagnosis [0.03%]
溶血状态下的高铁血红蛋白血症：一例建议对氧饱和度有差距的病人进行反射实验室检查以实现早期检测和诊断的病例报告
Christine Pham,Nicole Williams,Sarah Zavala
Christine Pham
Methemoglobinemia typically presents as functional anemia and hypoxemia. It is often recognized by a discordance between the pulse oximeter reading and the oxygen saturation measured on arterial blood gas. Methemoglobinemia can be inherited...
The Safety and Tolerability of High Dose Intravenous Push Levetiracetam [0.03%]
大剂量静脉注射左乙拉西坦的安全性和耐受性研究
Melissa Brandes,Tara Flack,William B Hays
Melissa Brandes
Objective: Levetiracetam (LEV) is a guideline-recommended antiepileptic that has been shown to be effective in the termination of status epilepticus. Traditionally, LEV is diluted in 100 mL of compatible fluid and administered as an intrave...
Improvements in Asthma Control After Pharmacist Involvement in an Outpatient Pediatric Asthma Clinic [0.03%]
药剂师参与哮喘门诊对改善儿童哮喘控制的作用研究
Lauren Anthony,Sandra Axtell,Bianca Nixon
Lauren Anthony
Background: Asthma is one of the most common pediatric disease states. However, current literature about outpatient pharmacy appointment effectiveness on pediatric asthma control is not widely available. Objective: To determine whether outp...
Fixed vs Weight-Based Dosing of Four-Factor Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Patients With a Non-Neurologic Hemorrhage [0.03%]
用于非神经学出血患者Xa因子抑制剂逆转的四因子凝血酶原复合物浓缩剂的固定剂量与按体重给药方式研究
Tyson Stokes,Christopher Johnson,Tyler Fish et al.
Tyson Stokes et al.
Background: There is a growing body of evidence to support that utilizing fixed dose vs weight-based dosing of Four-Factor prothrombin complex concentrate (4F-PCC) for Factor Xa inhibitor (FXaI) reversal is safe and efficacious. Objectives:...
Significant Publications on Infectious Diseases Pharmacotherapy in 2023 [0.03%]
2023年传染病药物治疗领域重要文献回顾
Alex V Stabler,Ricky Huynh-Phan,Khyati Amin et al.
Alex V Stabler et al.
Purpose: To provide a summarization of the most significant infectious diseases (ID) pharmacotherapy articles published in peer-reviewed literature in 2023. Summary: Members of the Houston Infectious Diseases Network (HIDN) nominated notabl...
Early Check-In Protocol: Identifying Medication Issues in Patients with Cancer at Health System Specialty Pharmacy [0.03%]
早期入住检查协议：识别癌症患者在医疗系统专业药房中的用药问题
Kayla Ann Phillips,Andrew Wash,Kristin Hutchinson et al.
Kayla Ann Phillips et al.
Introduction: Several studies have illustrated value in early patient contact following oral anticancer medication (OAM) initiation, particularly within the first 14 days of therapy, as adverse effects may lead to early d...
A Retrospective Study Evaluating the Safety and Clinical Impact of High Dose (6.75 grams) Piperacillin-Tazobactam Dosing in Critically Ill Obese Patients for Pneumonia [0.03%]
一项回顾性研究：评估超高剂量（6.75克）哌拉西林他唑巴坦治疗肥胖危重患者肺炎的安全性和临床影响
Christina X Tran,Matthew P Crotty,Ronda L Akins
Christina X Tran
Background: Piperacillin-tazobactam (PTZ) demonstrates time-dependent bactericidal activity, potentially increasing the need for higher dosing in obese and critically ill patients. However, limited information is available on the safety of ...
Retrospective Analysis of Ceftriaxone 1 Gram or 2 Grams for Bacteremia [0.03%]
回顾性分析评价治疗 bacteremia 患者的头孢曲松 1 克和 2 克疗法
Jae Hee Park,Alan Zhao,Rachel Bain et al.
Jae Hee Park et al.
Background: Ceftriaxone is a third-generation cephalosporin commonly used for treating bacteremia caused by gram-positive organisms such as Streptococcus spp. and gram-negative organisms such as Enterobacterales. The typical doses for treat...