TPGS Modified Phospholipid-free and Cholesterol-free Ethosomes Enhance Chemical Stability and Transdermal Permeation Of Retinol [0.03%]
新型不含卵磷脂和胆固醇的TPGS改良型以ethosome递送视黄醇提高其化学稳定性和经皮渗透性研究
Fanjun Xu,Meiting Li,Hang Ruan et al.
Fanjun Xu et al.
Retinol has emerged as a star ingredient in the cosmetics industry owing to its remarkable skincare efficacy. However, its major limitations-high irritation potential and chemical instability-necessitate further improvement. We developed a ...
Recent Advances in Surface-Engineered Polymeric Nanoparticles for Targeted Paclitaxel Delivery in Breast Cancer Therapy [0.03%]
表面工程聚合物纳米颗粒用于乳腺癌治疗中靶向紫杉醇递送的最新研究进展
Mahak Fatima,Fahad AlQahtani,Prashant Kesharwani
Mahak Fatima
Breast cancer remains a leading cause of cancer-related mortality worldwide. Paclitaxel (PTX), a first-line chemotherapeutic agent widely used in breast cancer, is widely used due to its potent mechanism of action against rapidly dividing c...
Besifloxacin-Loaded Nanostructured Lipid Carrier for Ocular Delivery: Formulation Optimization, In Vitro Characterization, and Safety Assessment [0.03%]
用于眼部给药的贝西氟沙星纳米结构脂质载体制剂优化、体外特征和安全评估
Mirla Anali Bazan Henostroza,Jéssica Fagionato Masiero,Carolina Falaschi Saponi et al.
Mirla Anali Bazan Henostroza et al.
Conjunctivitis, keratitis, endophthalmitis, and blepharitis are among the most prevalent bacterial eye infections. Topical eye drops are convenient but often exhibit low ocular bioavailability due to anatomical and physiological barriers, w...
Stability Assessment of FDA Approved Varenicline Tartrate Products for Critical Quality Attributes - N-Nitroso Varenicline, Solid Form, and Dissolution [0.03%]
盐酸伐尼克兰药品关键质量属性的稳定性研究- N-亚硝基伐尼克兰、固体形式及溶出度
Mariame A Hassan,Gereziher Sibhat,Indra K Reddy et al.
Mariame A Hassan et al.
The objectives of the present work were to study the effect of patient-in use and accelerated storage conditions on critical quality attributes (CQAs) of FDA approved varenicline tartrate (VRT) products. Four products (V1, V2, V3 and V4) of...
Functional Reclassification of Lipid-Based Drug Delivery Systems and Advances in Formulation Strategies and Manufacturing Challenges [0.03%]
基于脂质的药物递送系统功能再分类及配方策略和制造挑战方面的进展
Pranal Chhetri
Pranal Chhetri
Lipid-based drug delivery systems have progressed from a simple empirical solubilization tool towards a highly precise engineered platform, capable of delivering small drug molecules, biologics and nucleic acids. Despite proven achievements...
Comprehensive Modalities for Cataract Management: Preventive, Surgical, and Non-Surgical Approaches Using Conventional and Nanotechnology-Based Therapies [0.03%]
全面的白内障管理方法：使用传统和纳米技术基疗法的预防性、手术性和非手术性方法
Aya Hussein,Maha El-Kayal,Rehab Nabil Shamma et al.
Aya Hussein et al.
Among ocular diseases, cataract are globally considered the primary cause of blindness. Cataract development is mainly attributed to oxidative stress, which damages epithelial lens proteins and lipids, resulting in clouding or opacification...
Harnessing Hybrid Niosomes for Improved Oral Bioavailability of an Anticoagulant: Design, Optimization and In-Vivo Pharmacokinetics and Pharmacodynamics Evaluations [0.03%]
利用杂合Niosome改善抗凝药口服生物利用度的设计、优化及体内药物代谢动力学和药物效应学评价
Remonda Raafat Ragheb,Rodayana Atef,Kareem Abdou et al.
Remonda Raafat Ragheb et al.
Venous thromboembolism (VTE) and pulmonary embolism (PE), remains a major global health burden, necessitating prolonged and reliable anticoagulant therapy. Although Apixaban (APX) is a cornerstone oral anticoagulant for VTE management, its ...
Chandan Kumar Singh,Pran Kishore Deb
Chandan Kumar Singh
Polymer-drug conjugates (PDCs) represent a remarkable advancement in modern medicine, leveraging the physicochemical properties of polymers to enhance the efficacy and safety of therapeutic agents. This comprehensive review explores the his...
Artificial Intelligence-Guided Optimization of Hyaluronic Acid-Coated Liposomal Linagliptin for Targeted Management of Polycystic Ovary Syndrome [0.03%]
人工智能引导的透明质酸涂层脂质体林司肽普优化以靶向治疗多囊卵巢综合征
Marwa H S Dawoud,Aml H Zaghloul,Karen S Zakhari et al.
Marwa H S Dawoud et al.
Linagliptin, a DPP-4 inhibitor commonly used in the management of diabetes mellitus, has shown potential activity in polycystic ovary syndrome (PCOS). Linagliptin's therapeutic effectiveness is limited by its poor membrane permeability and ...
Albumin Nanoparticle-Based Delivery of Oxaliplatin-Oleic Acid Prodrug for Enhanced Breast Cancer Therapy [0.03%]
基于白蛋白纳米粒的奥沙利铂-油酸前药递送系统用于增强乳腺癌治疗的效果研究
Oly Katari,S Lokesh,Brojendra Nath Saren et al.
Oly Katari et al.
Triple-negative breast cancer (TNBC) remains a therapeutic outlier, with limited targeted options and frequent relapse despite chemotherapy. While platinum therapy can benefit some TNBC cases, including BRCA1/2-mutant tumors, toxicity and l...