Investigations on the Spatial Dust Distribution for Emission Site Localization in Containment [0.03%]
适用于 containment 中排放定位的粉尘分布空间考察研究
Hendrik Küllmar,Martin Schöler,Jonas Brügmann et al.
Hendrik Küllmar et al.
Dustiness and the spatial distribution of dust are major problems when working with highly active pharmaceutical ingredients. Therefore, the aim of this study was to develop a chamber setup that allows a reproducible atomization of small po...
Enhanced Tumor Treatment Outcomes of PEGylated Liposomal Gefitinib in Non-Small Cell Lung Cancer: A Comprehensive Preclinical Evaluation with Superior Therapeutic Efficacy [0.03%]
聚乙二醇化脂质体吉非替尼治疗非小细胞肺癌的增效研究：一项全面的临床前评估及优异的疗效分析
Rajeshkumar S Palva,Jolly R Parikh,Rajnikant M Suthar et al.
Rajeshkumar S Palva et al.
This study developed PEGylated liposomal gefitinib (GTL) to overcome clinical limitations of gefitinib therapy in NSCLC, including poor tumor targeting and suboptimal therapeutic outcomes. GTL was formulated using DPPC:cholesterol:mPEG-2000...
A Comparative Study of the Influence of Lipid Composition on Stability, In Vitro Release, and Antioxidant Activity of Quercetin-loaded Ceramide-containing Liposomes for Topical Delivery [0.03%]
含半乳糖脑苷脂质体递药体系的抗氧化性能研究及机制探讨
Ioannis Tsichlis,Veatriki-Despoina Koufonikola,Chrysi Chaikali et al.
Ioannis Tsichlis et al.
This study investigates the influence of phospholipid saturation by comparing hydrogenated soy phosphatidylcholine (HSPC) and egg yolk phosphatidylcholine (EPC) on the physicochemical characteristics, colloidal stability, drug release behav...
Comparative Study
AAPS PharmSciTech. 2025 Oct 6;26(8):235. DOI:10.1208/s12249-025-03226-0 2025
The Road to Precision Nanomedicine: An Insight on Drug Repurposing and Advances in Nanoformulations for Treatment of Cancer [0.03%]
通往精准纳米医学的道路：药物再利用和癌症治疗纳米制剂进展的见解
Yasmina Elmahboub,Rofida Albash,Sadek Ahmed et al.
Yasmina Elmahboub et al.
Cancer remains one of the most significant global health challenges, with its burden continuing to rise. The limitations of conventional anticancer therapies caused by the lack of tissue selectivity, demands urgent development of safer and ...
Dissolution Amelioration by Small Amounts of HPMC in the Difficult-to-solve Drug Combination Baicalein-imperatorin Co-Amorphous System: Dispersion and Crystallization Inhibition [0.03%]
小剂量羟丙基甲基纤维素改善难溶药物组合黄芩素-棱术内消旋系统的溶解：分散和结晶抑制作用研究
Tong Su,Xinli Liang,Qieying Jiang et al.
Tong Su et al.
Drug-drug co-amorphous systems (CAS) represent an emerging co-delivery strategy for combination therapy. Current research primarily explores combinations of poorly water-soluble drugs with water-soluble counterparts, while CAS comprising ex...
Advances in Pharmaceutical Cocrystals and Nano-Cocrystals: Strategies for Enhancing Solubility and Translating to Clinical Use [0.03%]
药物共晶和纳米共晶体研究进展：改善溶解性和临床转化策略
Roshan P Rao,Jawahar Natarajan,Samanwita Khanra et al.
Roshan P Rao et al.
Poor oral bioavailability in most modern pharmaceuticals is primarily caused by poor aqueous solubility. Most NCEs (New Chemical Entities) and nearly 40% of drugs on the market fall into either Biopharmaceutical Classification System (BCS) ...
A Novel Felbinac Transdermal Patch with High Permeability: Design, Development and Evaluation [0.03%]
一种高渗透性的菲布兰克透皮贴剂的设计、开发与评价
Li Qin,Cheng Liu,Ran Bai et al.
Li Qin et al.
The objective of the work was to design a novel felbinac transdermal patch to improve its transdermal delivery efficiency by adding chemical penetration enhancers. The adhesion properties and in vitro transdermal release performance were fi...
Inhalable Inclusion Cocrystal of Exocarpium Citri Grandis Volatile Oil for Treatment of Acute Lung Injury [0.03%]
广陈皮挥发油包合共晶的吸入制剂治疗急性肺损伤的研究
Ying Luo,Zeyu Li,Guilan Wang et al.
Ying Luo et al.
Acute lung injury (ALI) is the major cause of respiratory failure, often triggered by inflammatory responses resulting in disruption of the pulmonary gas-blood barrier. Existing treatments are limited by the poor bioavailability via systemi...
Formulation and Optimization of Memantine-Loaded PEGylated Single-Walled Carbon Nanotube Dispersions [0.03%]
聚乙二醇单壁碳纳米管分散体系的构建及缓释效果研究
Hoa Le,Hai V Nguyen,Amos Abioye et al.
Hoa Le et al.
The study aimed to develop stable single-walled carbon nanotube (SWCNT) dispersions in water that exhibit low protein adsorption in biological media, entrap Memantine, and release the drug in a controlled manner. Specifically, SWCNTs were f...
Factors Influencing the Dispersibility of Glycopyrronium Bromide and Indacaterol Maleate - Combined In Vitro and In Silico Study [0.03%]
影响甘羟铝溴化物和茚地那韦马来酸盐分散性的因素-结合体外和计算机模拟研究
Aleksandra Rzewińska,Jakub Szlęk,Ewelina Juszczyk et al.
Aleksandra Rzewińska et al.
The development of dry powder inhalers (DPIs) for pulmonary drug delivery is complex, requiring optimization of variable factors to ensure effective lung deposition. This study investigates the factors influencing the dispersibility of glyc...