Formulation-Based Repurposing of Mifepristone Using a Drug-Eluting Intrauterine Insert for Localized Uterine Fibroid Therapy: A Preclinical Study [0.03%]
一种用于局部子宫肌瘤治疗的米非司酮药物释放宫内缓释系统的研发：一项基于药物再定位的临床前研究
Riya Patel,Alkesh Patel,Gayatri Patel
Riya Patel
The majority of currently available treatments for uterine fibroids (UFs) are invasive and are delivered via either oral or parenteral means. Mifepristone (MFP), a particular drug that alters the activity of progesterone receptors, is selec...
Efficient Loading of Rabeprazole Sodium via Porous Anion Exchange Resin for Enteric Delivery [0.03%]
雷贝拉唑钠负载离子交换树脂结肠靶向递送的研究
Hongfei Liu,Luyuan Cai,Yutian Dou et al.
Hongfei Liu et al.
Rabeprazole sodium (RAB), a widely used proton pump inhibitor for treating gastroesophageal reflux disease (GERD), faces limitations in administration to pediatric and dysphagic patients due to the swallowing difficulties posed by conventio...
Influence of pH, Buffering Capacity, Ionic Strength, Bile Salts, and Model Drugs on Micellization Behaviour of Salcaprozate Sodium in Physiological Range pH Buffers [0.03%]
生理范围pH缓冲溶液中十二指肠磺胺钠胶束化行为的pH、缓冲容量、盐浓度、胆盐及模型药物的影响
Sideequl Akbar,Anumol Joseph,Adarsh Malgave et al.
Sideequl Akbar et al.
Salcaprozate sodium (SNAC) is an FDA GRAS-listed permeation enhancer used in oral semaglutide and vitamin B12 formulations. Although its rapid and reversible membrane-perturbing effects are well recognised, it's in vivo performance is highl...
Smart In Situ-Forming Ocular Therapeutics for Dry Eye Disease: Bridging Biomaterials, Nanotechnology, and Clinical Translation [0.03%]
用于干眼病的智能原位形成眼部治疗剂：生物材料、纳米技术和临床转化之间的联系
Adiba Rahman,Poonam Kushwaha,Bipasha Ray et al.
Adiba Rahman et al.
Dry eye disease (DED) is a multifactorial inflammatory condition of the ocular surface that significantly impairs quality of life through tear film instability and chronic irritation. Despite the prevalence of DED, conventional topical ther...
Formulation Design of a Hot-melt Extrusion-Based Amorphous Solid Dispersion to Optimize Palatability of Berberine Hydrochloride with In Vitro and In Vivo Evaluation [0.03%]
基于热熔挤出的不良嗅味盐酸小檗碱无定型固体分散体制备设计及体内外评价研究
Jiayu Zhang,Shengyu Zhang,Chunxue Wang et al.
Jiayu Zhang et al.
Berberine hydrochloride (BH) is a naturally isoquinoline alkaloid extracted from Coptis species. It possesses an extremely intense bitter taste and is classified as a Biopharmaceutics Classification System (BCS) class III drug, exhibiting h...
Optimizing Particle Size of pH Modifiers Enhances Dissolution of Weakly Basic Drugs [0.03%]
pH调节剂的粒径优化可增强弱碱性药物的溶解度
Kejia Wu,Yupeng Feng,Zherui Zhang et al.
Kejia Wu et al.
Objective: This study aimed to investigate the pH-dependent dissolution of the weakly basic drug carvedilol (BCS Class II) and systematically examine the influence of citric acid concentration and particle size on its rel...
Combining of Spray Drying and Dry Granulation to Prepare Orodispersible Tablets: Influence of Spray-Dried Particle Size on Tablet Properties [0.03%]
喷雾干燥和干法制粒联用制备或递释片的研究：喷雾干燥粒子大小对片剂性质的影响
Thao Tranová,Jan Loskot,Petr Koukal et al.
Thao Tranová et al.
The study investigated how the particle size of spray-dried powders containing a model drug and hypromellose phthalate incorporated to granules impacts the powder flow properties, compressibility, and tablet properties. The spray-dried prod...
Thermo-Sensitive Polymeric Networks for Next-Generation Wound Management: A Review [0.03%]
下一代伤口管理的热敏聚合物网络：综述论文
Akshay Kumar,Prachee Nirmale,Suresh Babu Kondaveeti et al.
Akshay Kumar et al.
Wound healing is a dynamic and highly coordinated biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. However, chronic wounds such as diabetic ulcers, burn injuries, and infected wounds often fail to...
DoE-Optimized Chitosan-Coated pH-Sensitive Liposomes for Targeted Nose-to-Brain Delivery of Temozolomide [0.03%]
基于响应面法优化的pH敏感型壳聚糖包衣脂质体携载替莫唑胺鼻黏膜给药研究
Ashish Jain,Harsh P Nijhawan,Khushwant S Yadav
Ashish Jain
Glioblastoma is an aggressive brain tumor with limited treatment efficacy due to poor blood-brain barrier (BBB) penetration and intrinsic resistance. Temozolomide (TMZ), the frontline chemotherapeutic, undergoes rapid hydrolysis at physiolo...
Can a Lipid-Containing Co-Processed Excipient Overcome Compression Challenges Associated with a Cohesive and Viscoelastic API? [0.03%]
一种含脂质的共处理辅料能否克服 cohesive 和粘弹性的活性药物成分压缩带来的挑战？
Ivana Aleksić,Teodora Glišić,Slobodanka Ćirin-Varađan et al.
Ivana Aleksić et al.
Although direct compression is the preferred method for manufacturing tablets, it has very limited application due to the poor flowability and compaction properties of most active pharmaceutical ingredients (APIs). Co-processed excipients h...