Development, Characterization, and Molecular Dynamics Simulation of Andrographolide Nanosuspensions Utilizing Hummer Acoustic Resonance Technology [0.03%]
利用Hummer超声共振技术开发、表征和分子动力学模拟andrographolide纳米混悬液
Li Wang,Xiaoyang Zhang,Jianlu Qu et al.
Li Wang et al.
Andrographolide (AG) is a diterpenoid lactone, widely recognized for its potent anti-inflammatory and immunomodulatory properties. However, AG's clinical applications are significantly limited due to its poor water solubility. The aim of th...
Taste Masking of Primaquine Phosphate: A Comparative Evaluation of Three Taste Masking Agents [0.03%]
磷酸氯喹的味道掩盖作用：三种味道掩蔽剂的比较评估
Galande Ankit,Gagare Tejashree,Sahu Surbhi et al.
Galande Ankit et al.
The work involved taste masking of primaquine phosphate (PMQ), an intensely bitter drug used in the prevention and treatment of relapses of malarial infections caused by Plasmodium vivax and ovale. Drug and cation exchange resins viz, Amber...
Comparative Study
AAPS PharmSciTech. 2025 Jun 11;26(5):168. DOI:10.1208/s12249-025-03162-z 2025
Rabab Kamel,Giuseppina Nocca,Elena Mazzinelli et al.
Rabab Kamel et al.
Clay minerals or nanoclays are layered aluminosilicate nanoparticles with unique physicochemical properties, excellent biocompatibility, high surface area, lamellar structure, diverse ion-exchange capacity, tuneable surface chemistry enabli...
Nanosizing and Surface Modification by Propellant Assisted Aerosolization Enhances Solubility and Dissolution of Estradiol [0.03%]
推进剂雾化纳米制备及表面修饰改善雌二醇溶出度的研究
Gaurav K Jain,Gaurav Chaudhary,Mohammad Akhlaquer Rahman et al.
Gaurav K Jain et al.
Objective: A novel method for the development of uniform, nanosized, crystalline particles of estradiol valerate (EV) by the propellant assisted aerosolization (PAA) technique as an alternative to supercritical carbon dio...
Development and Evaluation of Huperzine A-Loaded Microneedles for Transdermal Delivery and Pretreatment of GD Poisoning [0.03%]
用于经皮给药和GD中毒预处理的Huperzine A载药微针的开发与评估
Guixiang Yang,Yi Zhang,Chong Li et al.
Guixiang Yang et al.
Huperzine A (Hup A), a reversible acetylcholinesterase inhibitor, shows protective potential against neurotoxic poisoning. Current formulations (oral tablets/capsules and injectables) face limitations: oral administration suffers from first...
Sanjeevini M,Harini Priya Pa,Rakshitha L et al.
Sanjeevini M et al.
The pH of the formulation can affect the pH of the skin surface. However, the skin's pH is known to recover rapidly due to the substantial buffer capacity associated with the skin. The objective of the project was to investigate the effect ...
Application of Physiologically Based Biopharmaceutics Modeling (PBBM) to Establish Clinically Relevant Dissolution Specifications for a Prolonged Release Tablet Formulation of Verapamil, a BCS Class I Drug [0.03%]
基于生理的生物药剂学模型在制定班布特罗缓释片临床相关溶出度标准中的应用研究
Anagha Damre,Aniruddha Banerjee
Anagha Damre
Our work aimed at setting clinically relevant dissolution specifications for a prolonged release formulation of verapamil, a BCS Class I drug. We have used a two-pronged approach- a Level A IVIVC correlation supplemented with virtual bioequ...
Correction: Laser-mediated Solutions: Breaking Barriers in Transdermal Drug Delivery [0.03%]
关于激光介导解决方案：突破经皮药物递送屏障的纠正文章
Ehsan Haghsay Khashechi,Abolfazl Afaghmehr,Niloofar Heidarizade et al.
Ehsan Haghsay Khashechi et al.
Published Erratum
AAPS PharmSciTech. 2025 Jun 4;26(5):161. DOI:10.1208/s12249-025-03125-4 2025
Degradable Hydrogel Microspheres for Drug Delivery: In Vitro Performance and Influence of E-Beam Sterilization [0.03%]
可降解的药物递送用氢凝胶微球：体外性能及E射线灭菌的影响
Laurent Bédouet,Anne Beilvert,Emeline Servais et al.
Laurent Bédouet et al.
The present work examines the in vitro drug delivery performance of degradable microspheres (DrugMic) composed of a crosslinked hydrogel of poly(ethylene glycol), with particular interest on the effect of e-beam sterilization on the stabili...
Recent Advances in Development of Buccal Formulations: From Small to Macromolecules [0.03%]
近年颊黏膜给药制剂的研究进展：从低分子量到高分子量药物
Vrundakumari R Solanki,Vijaykumar K Parmar
Vrundakumari R Solanki
Buccal drug delivery offers a promising alternative to conventional oral administration, bypassing hepatic first-pass metabolism and gastric degradation that often limit drug bioavailability. This review explores the anatomical and physiolo...