Mesoporous Silica Nanoparticles for Ocular Drug Delivery: Synthesis, Functionalization, and Safety Insights [0.03%]
介孔二氧化硅纳米粒子用于眼部药物传输：合成、功能化及安全性研究
Lajja Patel,Tejal Mehta
Lajja Patel
This review explores mesoporous silica nanoparticles (MSNs) as emerging nano-drug delivery systems for ocular diseases and provides a comprehensive overview of their application in ophthalmic drug delivery, including eye anatomy, ocular bar...
The Application of Machine Learning in the Development of Co-Amorphous Dry Powder Inhalation [0.03%]
机器学习在协同无定形干粉吸入制剂开发中的应用
Ziling Zhou,Xian Chen,Yuxin Liu et al.
Ziling Zhou et al.
Besides improving drug solubility and stability, co-amorphous systems (COAMS) have recently been reported to enhance the pulmonary delivery efficiency of dry powder inhalation (DPI), offering a novel approach to the development of DPI. Conv...
Understanding the Influence of Molarity, Buffer Capacity, and pH on Product-specific Guidance Dissolution Method for Developing a Discriminatory Dissolution Method for the Development of Mesalamine Products [0.03%]
理解浓度、缓冲容量和pH值对美沙拉嗪产品指导溶出法的影响，以开发一种具有鉴别力的产品的溶出法
Ankit Kumar,Sakshi Kunjir,Prakash Kumar Sirvi et al.
Ankit Kumar et al.
Achieving therapeutic intraluminal Mesalamine (MES) concentration at colonic lesion sites is influenced by variable gastrointestinal (GI) pH, buffer capacity (β), fluid volume, viscosity, and transit time. Conventional dissolution tests of...
Cyclodextrins: Synthesis, Pharmaceutical Applications, Drug Delivery Systems and Safety Perspectives [0.03%]
环糊精：合成、药用应用、药物递送系统及安全性展望
Aman Kumar,Ravi Raj Pal,Preeti Patel et al.
Aman Kumar et al.
Cyclodextrins (CDs) are cyclic oligosaccharides composed of α-(1,4)-linked glucopyranose units that have emerged as multifunctional and versatile pharmaceutical excipients. One of the major challenges in modern drug development is that nea...
Hybrid Photometric-Geometric 3D Reconstruction Framework for Manufacturing-Oriented Assessment of Tablet Surface CQAs under PAT/RTRT [0.03%]
基于PAT/RTRT的片剂表面CQA评估的混合光度几何3D重建框架
Phakdee Sukpornsawan,Jakkarin Suksawatchon,Watcharaphong Chaemsawang et al.
Phakdee Sukpornsawan et al.
Surface-related critical quality attributes (CQAs) of solid oral dosage forms influence mechanical integrity, coating uniformity, imprint readability, and downstream product performance. Conventional two-dimensional visual inspection and ge...
A Quality-by-Design Approach Based Formulation, Optimization, In Vitro and Ex Vivo Evaluation of Delafloxacin-Loaded Ethosomal Gel [0.03%]
基于制剂、优化和体外及在体评估的德拉诺氟沙星载乙osome凝胶的质量设计方法研究
Deesha Jain,Devaraj Yallappa,Modhusmita Gogoi et al.
Deesha Jain et al.
The current work aims to fabricate and examine a delafloxacin (DFX)-loaded ethosomal (ETHs) gel for improved topical delivery and improved antibacterial efficiency against skin infections. ETHs were prepared using the cold method followed b...
Liposome-Based Drug Delivery Systems: Mechanisms, Preparation Strategies, Clinical Status, and Therapeutic Applications [0.03%]
基于脂质体的药物递送系统：机制、制备策略、临床现状及治疗应用
Abdul Shadab,Md Faheem Haider,Mohammad Abohassan
Abdul Shadab
Nanotechnology-based drug delivery systems have significantly advanced modern pharmaceutics by addressing limitations associated with conventional therapies, including poor solubility, rapid systemic clearance, and nonspecific drug distribu...
Development of a New Aerosol Delivery System for Administering Aerosol Surfactant Therapy to Preterm Infants Through a Laryngeal Mask Airway [0.03%]
一种新的声门上气道导管给药装置用于早产儿表面活性物质治疗的开发研究
Sarah C Strickler,Caleb J Dalton,Felicia G Hall et al.
Sarah C Strickler et al.
In this study, aerosol surfactant therapy administered through a laryngeal mask airway (LMA) was investigated as an alternative to the more invasive approach of surfactant liquid bolus instillation, which carries significant risks to infant...
Emerging and Prospective Engineering Technologies Enabling Microneedle Based Vaccine Therapeutics [0.03%]
新兴和有前景的工程科技助力微针疫苗透皮免疫技术的发展与应用展望
N Ahmad,N A Jalil,R Benziane et al.
N Ahmad et al.
Microneedles (MNs) have progressed to a potentially viable method of transdermal vaccination and have accrued immense attention in recent years. By overcoming first-pass metabolism, this emerging technology elicits efficacious therapeutic e...
Integrative Perspectives on Pirfenidone: Mechanistic Insights, Pharmacodynamics, and Emerging Therapeutic Strategies for Fibrotic Disorders [0.03%]
吡非尼酮的整合视角：机制洞察、药理动态及抗纤维化治疗策略的新进展
Abhidnya Kudterkar,Sarika Wairkar
Abhidnya Kudterkar
Pirfenidone is a synthetic pyridone derivative that is primarily beneficial in treating idiopathic pulmonary fibrosis (IPF). Initially synthesized as an anti-inflammatory agent, it was later identified as the first oral antifibrotic therapy...