Topical Foam for Simultaneous Treatment and Decontamination of Chemical Warfare Agents on Dermal Exposure [0.03%]
一种用于同时治疗和除污染的泡沫制剂在化学战剂皮肤接触中的应用
Sonalika Arup Bhattaccharjee,Mohammad Shajid Ashraf Junaid,Meheli Ghosh et al.
Sonalika Arup Bhattaccharjee et al.
Being highly toxic and a quick-acting vesicant, even small amounts of lewisite if not decontaminated immediately are rapidly absorbed into systemic circulation via skin exposure, leading to acute poisoning and death. The skin is the first m...
Recent Advances in the Local Drug Delivery Systems for Diabetic Wound Healing: A Comprehensive Review [0.03%]
用于糖尿病伤口愈合的局部药物输送系统的最新进展：综述
Reem Khaled Wassif,Rehab Nabil Shamma,Nada M El-Hoffy et al.
Reem Khaled Wassif et al.
Wound management in diabetic patients holds significant importance in both clinical and social contexts due to the delayed and compromised healing that these individuals experience. Diabetic wounds exhibit slow and incomplete healing, incre...
Intranasal Delivery of Cetrorelix Via Lipid Liquid Crystal Nanoparticles: Characterization and Pharmacokinetic Studies in Rats [0.03%]
脂质液晶纳米颗粒递送促性腺激素释放激素拮抗剂塞特罗利克斯的鼻黏膜吸收： rats 的药代动力学研究
Soheil Tafazzoli Mehrjardi,Mohsen Tafaghodi,Saba Malek et al.
Soheil Tafazzoli Mehrjardi et al.
Nasal sprays are extensively researched due to their rapid absorption, high bioavailability, and low side effects. Lipid liquid crystal nanoparticles (LLCNs) are being considered as potential carriers for intranasal delivery. LLCs loaded wi...
Hot Melt Extruded Aceclofenac-Soluplus® Solid Dispersion: Mechanistic View of Miscibility and Drug-Carrier Interactions for Enhanced Dissolution [0.03%]
热熔挤出醋氯酚酸-Soluplus®固体分散体：改善溶解性的药物载体相互作用的机制研究
Likhitha U,Roushan Bharti,Reema Narayan et al.
Likhitha U et al.
Aceclofenac (ACF), a Non-Steroidal Anti-Inflammatory Drug (NSAID), is formulated with Soluplus® (SOLP) to enhance solubility and bioavailability. This study presents a distinct approach by utilizing Hot Melt Extrusion (HME) to prepare Acec...
Formulation Development and Characterization of Bigels Containing Curcumin for Topical Skin Delivery [0.03%]
一种可适用于皮肤给药的含姜黄素的大体积凝胶体系的设计开发及表征研究
Lord Sam Liston,Suranate Phanapithakkun,Nuttakul Pimsarn et al.
Lord Sam Liston et al.
Curcumin, a pleiotropic molecule, has been reported to modulate skin health and functions owing to its anti-inflammation, wound healing, antimicrobial, and anti-aging effects. Curcumin, a lipophilic molecule, exhibits poor skin penetration ...
Co-delivery of Exemestane and Genistein via Chitosan Coated Liposomes for Enhanced Antitumor Effect and Bone Loss Prevention in Breast Cancer Therapy: In Vivo Evaluation [0.03%]
壳聚糖涂层脂质体共递送 exemestane 和 genistein 以增强乳腺癌治疗的抗肿瘤效果和防治骨丢失：体内评价
Shwetakshi Sharma,S M Kawish,Priya Gupta et al.
Shwetakshi Sharma et al.
Breast cancer (BC) is the most prevalent form of cancer among women worldwide, accounting for approximately 36% of cancer cases. Due to its inimitable pathological expression and restricted success of accessible therapeutic modalities, fana...
Design of Passion Fruit Oil Emulgel for Topical Chrysin Delivery and Ex Vivo Evaluation of Skin Permeation by Photoacoustic Spectroscopy [0.03%]
采用光声光谱法评价外用皮肤渗透的黄酮醇递药凝胶剂的设计及体外评价
Bruna Gheller de Souza,Lidiane Vizioli de Castro Hoshino,Thalita Schilive Faccin et al.
Bruna Gheller de Souza et al.
Chrysin, a flavonoid effective against various skin cancers, displays poor solubility, skin permeation, and bioavailability. Emulgel emerges as an innovative and promising strategy for the topical administration of chrysin, offering signifi...
Phospholipid Complex-based Topical Gel for Codelivery of Erlotinib and Methotrexate in Psoriasis [0.03%]
用于银屑病治疗的埃洛替尼和甲氨蝶呤共递送磷脂复合物基凝胶体系
Sanyog Jain,Shivani Mali,Junia Akhtar et al.
Sanyog Jain et al.
Topical drug delivery systems offer a targeted and patient-compliant approach for managing psoriasis, enabling noninvasive, localized, and sustained therapy, with reduced systemic side effects and improved therapeutic outcomes. In this stud...
Development and In Vitro Characterization of Azithromycin-PLGA Nanoparticles Loaded Thermoresponsive Hydrogels: A Quality by Design Approach Toward Intra-Articular Delivery of Macrolides [0.03%]
质量源于设计的载有阿奇霉素-聚乳酸羟基乙酸纳米粒的热响应水凝胶的开发及体外评价：一种关节内给药大环内酯类药物的方法
Bao Ngoc Tran,Cam Le Ha,Duyen Thi Thuy Vu et al.
Bao Ngoc Tran et al.
Azithromycin (AZT), a macrolide antibiotic, has recently been explored as an injection therapy for osteoarthritis. However, its instability and poor solubility limit its effect due to an insufficient quantity and duration at the target site...
Optimizing Extended-release Formulation of l-tetrahydropalmatine Based on In Vivo Outcomes Using Integrated Modeling Approaches [0.03%]
基于体内结果集成建模方法优化左四氢巴马汀缓释制剂配方
Thi-Phuong-Dung Pham,Huy Minh Dao,Nguyen-My-Linh Pham et al.
Thi-Phuong-Dung Pham et al.
l-Tetrahydropalmatine (l-THP) is a promising drug candidate for addiction treatment and needs to be delivered in extended-release dosage forms for safety and efficiency. This study aims to optimize extended-release formulations containing l...